Virus enhances IgE- and non-IgE-dependent histamine release induced by bacteria and other stimulators

P. Clemtsen*, M. Pedersen, H. Permin, F. Espersen, J. O. Jarløv, S. Norn

*Corresponding author for this work

    Research output: Contribution to journalArticleResearchpeer-review

    Abstract

    Histamine release from human basophil leukocytes was triggered by Staph. aureus, Salmonella enteriditis, non-haemolytic streptococci, or E. coli. Influenza A virus was found to enhance the mediator release and the effect was caused by synergism, since the virus did not induce release of histamine per se. This potentiating effect of the virus was seen both when the bacteria-induced histamine release was IgE-dependent (i.e. patient sensitized to the bacterium) and when the bacterium caused mediator release by a non-immunological mechanism independent of IgE (putative sugar-lectin mediated). Histamine release induced by anti-IgE and calcium ionophore or agarose-beads was also enhanced in the presence of the virus. These findings indicate that influenza A virus potentiates both IgE-and non-IgE-mediated histamine release induced by bacteria and other stimulators.

    Original languageEnglish
    Pages (from-to)61-63
    Number of pages3
    JournalAgents and Actions
    Volume30
    Issue number1-2
    DOIs
    Publication statusPublished - 1 Apr 1990

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