Stratum corneum damage and ex vivo porcine skin water absorption - A pilot study

C. Duch Lynggaard; D. Bang Knudsen; G. B.E. Jemec

doi:10.1159/000241298

Stratum corneum damage and ex vivo porcine skin water absorption - A pilot study

C. Duch Lynggaard^*
, D. Bang Knudsen
, G. B.E. Jemec

^*Corresponding author for this work

Dermatology

Research output: Contribution to journal › Letter › Research › peer-review

Abstract

A simple ex vivo screening technique would be of interest for mass screening of substances for potential barrier disruptive qualities. Ex vivo water absorption as a marker of skin barrier integrity was studied on pig ear skin. Skin water absorption was quantified by weighing and weight changes were found to reflect prehydration barrier damage. It is suggested that this simple model may be elaborated to provide a rapid, economical screening tool for potential skin irritants.

Original language	English
Pages (from-to)	295-298
Number of pages	4
Journal	Skin Pharmacology and Physiology
Volume	22
Issue number	6
DOIs	https://doi.org/10.1159/000241298
Publication status	Published - 1 Nov 2009

Keywords

Porcine skin
Skin irritants
Water absorption barrier damage

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10.1159/000241298

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title = "Stratum corneum damage and ex vivo porcine skin water absorption - A pilot study",

abstract = "A simple ex vivo screening technique would be of interest for mass screening of substances for potential barrier disruptive qualities. Ex vivo water absorption as a marker of skin barrier integrity was studied on pig ear skin. Skin water absorption was quantified by weighing and weight changes were found to reflect prehydration barrier damage. It is suggested that this simple model may be elaborated to provide a rapid, economical screening tool for potential skin irritants.",

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AU - Duch Lynggaard, C.

AU - Bang Knudsen, D.

AU - Jemec, G. B.E.

PY - 2009/11/1

Y1 - 2009/11/1

N2 - A simple ex vivo screening technique would be of interest for mass screening of substances for potential barrier disruptive qualities. Ex vivo water absorption as a marker of skin barrier integrity was studied on pig ear skin. Skin water absorption was quantified by weighing and weight changes were found to reflect prehydration barrier damage. It is suggested that this simple model may be elaborated to provide a rapid, economical screening tool for potential skin irritants.

AB - A simple ex vivo screening technique would be of interest for mass screening of substances for potential barrier disruptive qualities. Ex vivo water absorption as a marker of skin barrier integrity was studied on pig ear skin. Skin water absorption was quantified by weighing and weight changes were found to reflect prehydration barrier damage. It is suggested that this simple model may be elaborated to provide a rapid, economical screening tool for potential skin irritants.

KW - Porcine skin

KW - Skin irritants

KW - Water absorption barrier damage

UR - https://www.scopus.com/pages/publications/70349420144

U2 - 10.1159/000241298

DO - 10.1159/000241298

M3 - Letter

C2 - 19786822

AN - SCOPUS:70349420144

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SP - 295

EP - 298

JO - Skin Pharmacology and Physiology

JF - Skin Pharmacology and Physiology

IS - 6

ER -

Stratum corneum damage and ex vivo porcine skin water absorption - A pilot study

Abstract

Keywords

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