Restless legs syndrome is associated with major comorbidities in a population of Danish blood donors

Maria Didriksen; Richard P. Allen; Brendan J. Burchell; Lise W. Thørner; Andreas S. Rigas; Emanuele Di Angelantonio; Maria H. Nielsen; Poul J. Jennum; Thomas Werge; Christian Erikstrup; Ole B. Pedersen; Kaspar Nielsen; Mie T. Bruun; Kristoffer S. Burgdorf; Erik Sørensen; Henrik Ullum

doi:10.1016/j.sleep.2018.02.007

Restless legs syndrome is associated with major comorbidities in a population of Danish blood donors

Maria Didriksen
, Richard P. Allen
, Brendan J. Burchell
, Lise W. Thørner
, Andreas S. Rigas
, Emanuele Di Angelantonio
, Maria H. Nielsen
, Poul J. Jennum
, Thomas Werge
, Christian Erikstrup
, Ole B. Pedersen
, Kaspar Nielsen
, Mie T. Bruun
, Kristoffer S. Burgdorf
, Erik Sørensen
, Henrik Ullum^*

^*Corresponding author for this work

Clinical Immunology

Research output: Contribution to journal › Article › Research › peer-review

Abstract

Background: Restless Legs Syndrome (RLS) is characterized by uncomfortable nocturnal sensations in the legs making sedentary activities and sleep difficult, and is thus linked with psychosocial distress. Due to the symptomatology and neurobiology of RLS (disrupting brain iron and dopamine) it is likely that RLS associates with poorer health-related quality of life (HRQL) and depressive disorder. The objective of this study was to investigate the RLS-HRQL and the RLS-depressive disorder links in a generally healthy population that is not biased by medications. Methods: Complete data, including the Cambridge–Hopkins RLS questionnaire, the 12-item short-form standardized health survey (SF-12), the Major Depression Inventory (MDI), body mass index, smoking status, alcohol consumption, and education were available for 24,707 participants enrolled in the Danish Blood Donor Study from May 1, 2015 to February 1, 2017. Information on quality of sleep was available for all RLS cases. T-tests and multivariable logistic regression models were applied to examine the associations of RLS and MDI scores, and the physical and mental component scores (PCS and MCS) of SF-12, respectively. Analyses were conducted separately for men and women. Results: RLS associated with poorer MCS and poorer PCS. Moreover, Participants with RLS were more likely to classify with depressive disorder. Poor quality of sleep was associated with depressive disorder and poorer MCS among RLS cases, and with poorer PCS in female RLS cases. Conclusion: Thus, we demonstrated that RLS is associated with a significantly lower HRQL and a higher prevalence of depressive disorder among otherwise healthy individuals.

Original language	English
Pages (from-to)	124-131
Number of pages	8
Journal	Sleep Medicine
Volume	45
DOIs	https://doi.org/10.1016/j.sleep.2018.02.007
Publication status	Published - May 2018

Funding

This study was supported with grants from The Danish Council for Independent Research – Medical Sciences, The Danish Administrative Regions, The Danish Blood Donor Research Foundation, The Danish Bio- and Genome Bank, and The Brothers Hartmann Foundation. The funders had no role in study design, data collection and analysis, decision to publish, or in preparation of the manuscript. Thanks to the personnel in the Danish blood banks and the financial funders of the present study. This study was supported with grants from The Danish Council for Independent Research (grant no.: 09-069412 ), The Danish Administrative Regions (grant no.: 02/2611 ), Regionernes Bio-og Genombank , The Danish Blood Donor Research Foundation , and The Brothers Hartmann Foundation . The funders had no role in study design, data collection and analysis, decision to publish, or in preparation of the manuscript.

Keywords

Comorbidities
Depressive disorder
Quality of life
Restless legs syndrome
Sleep disturbance
The Danish blood donor study

Access to Document

10.1016/j.sleep.2018.02.007

Cite this

Didriksen, M., Allen, R. P., Burchell, B. J., Thørner, L. W., Rigas, A. S., Di Angelantonio, E., Nielsen, M. H., Jennum, P. J., Werge, T., Erikstrup, C., Pedersen, O. B., Nielsen, K., Bruun, M. T., Burgdorf, K. S., Sørensen, E., & Ullum, H. (2018). Restless legs syndrome is associated with major comorbidities in a population of Danish blood donors. Sleep Medicine, 45, 124-131. https://doi.org/10.1016/j.sleep.2018.02.007

@article{3b73c34cb563411fb5d8ecc20306b03d,

title = "Restless legs syndrome is associated with major comorbidities in a population of Danish blood donors",

abstract = "Background: Restless Legs Syndrome (RLS) is characterized by uncomfortable nocturnal sensations in the legs making sedentary activities and sleep difficult, and is thus linked with psychosocial distress. Due to the symptomatology and neurobiology of RLS (disrupting brain iron and dopamine) it is likely that RLS associates with poorer health-related quality of life (HRQL) and depressive disorder. The objective of this study was to investigate the RLS-HRQL and the RLS-depressive disorder links in a generally healthy population that is not biased by medications. Methods: Complete data, including the Cambridge–Hopkins RLS questionnaire, the 12-item short-form standardized health survey (SF-12), the Major Depression Inventory (MDI), body mass index, smoking status, alcohol consumption, and education were available for 24,707 participants enrolled in the Danish Blood Donor Study from May 1, 2015 to February 1, 2017. Information on quality of sleep was available for all RLS cases. T-tests and multivariable logistic regression models were applied to examine the associations of RLS and MDI scores, and the physical and mental component scores (PCS and MCS) of SF-12, respectively. Analyses were conducted separately for men and women. Results: RLS associated with poorer MCS and poorer PCS. Moreover, Participants with RLS were more likely to classify with depressive disorder. Poor quality of sleep was associated with depressive disorder and poorer MCS among RLS cases, and with poorer PCS in female RLS cases. Conclusion: Thus, we demonstrated that RLS is associated with a significantly lower HRQL and a higher prevalence of depressive disorder among otherwise healthy individuals.",

keywords = "Comorbidities, Depressive disorder, Quality of life, Restless legs syndrome, Sleep disturbance, The Danish blood donor study",

author = "Maria Didriksen and Allen, \{Richard P.\} and Burchell, \{Brendan J.\} and Th{\o}rner, \{Lise W.\} and Rigas, \{Andreas S.\} and \{Di Angelantonio\}, Emanuele and Nielsen, \{Maria H.\} and Jennum, \{Poul J.\} and Thomas Werge and Christian Erikstrup and Pedersen, \{Ole B.\} and Kaspar Nielsen and Bruun, \{Mie T.\} and Burgdorf, \{Kristoffer S.\} and Erik S{\o}rensen and Henrik Ullum",

year = "2018",

month = may,

doi = "10.1016/j.sleep.2018.02.007",

language = "English",

volume = "45",

pages = "124--131",

journal = "Sleep Medicine",

issn = "1389-9457",

publisher = "Elsevier B.V.",

}

Didriksen, M, Allen, RP, Burchell, BJ, Thørner, LW, Rigas, AS, Di Angelantonio, E, Nielsen, MH, Jennum, PJ, Werge, T, Erikstrup, C, Pedersen, OB, Nielsen, K, Bruun, MT, Burgdorf, KS, Sørensen, E & Ullum, H 2018, 'Restless legs syndrome is associated with major comorbidities in a population of Danish blood donors', Sleep Medicine, vol. 45, pp. 124-131. https://doi.org/10.1016/j.sleep.2018.02.007

TY - JOUR

T1 - Restless legs syndrome is associated with major comorbidities in a population of Danish blood donors

AU - Didriksen, Maria

AU - Allen, Richard P.

AU - Burchell, Brendan J.

AU - Thørner, Lise W.

AU - Rigas, Andreas S.

AU - Di Angelantonio, Emanuele

AU - Nielsen, Maria H.

AU - Jennum, Poul J.

AU - Werge, Thomas

AU - Erikstrup, Christian

AU - Pedersen, Ole B.

AU - Nielsen, Kaspar

AU - Bruun, Mie T.

AU - Burgdorf, Kristoffer S.

AU - Sørensen, Erik

AU - Ullum, Henrik

PY - 2018/5

Y1 - 2018/5

N2 - Background: Restless Legs Syndrome (RLS) is characterized by uncomfortable nocturnal sensations in the legs making sedentary activities and sleep difficult, and is thus linked with psychosocial distress. Due to the symptomatology and neurobiology of RLS (disrupting brain iron and dopamine) it is likely that RLS associates with poorer health-related quality of life (HRQL) and depressive disorder. The objective of this study was to investigate the RLS-HRQL and the RLS-depressive disorder links in a generally healthy population that is not biased by medications. Methods: Complete data, including the Cambridge–Hopkins RLS questionnaire, the 12-item short-form standardized health survey (SF-12), the Major Depression Inventory (MDI), body mass index, smoking status, alcohol consumption, and education were available for 24,707 participants enrolled in the Danish Blood Donor Study from May 1, 2015 to February 1, 2017. Information on quality of sleep was available for all RLS cases. T-tests and multivariable logistic regression models were applied to examine the associations of RLS and MDI scores, and the physical and mental component scores (PCS and MCS) of SF-12, respectively. Analyses were conducted separately for men and women. Results: RLS associated with poorer MCS and poorer PCS. Moreover, Participants with RLS were more likely to classify with depressive disorder. Poor quality of sleep was associated with depressive disorder and poorer MCS among RLS cases, and with poorer PCS in female RLS cases. Conclusion: Thus, we demonstrated that RLS is associated with a significantly lower HRQL and a higher prevalence of depressive disorder among otherwise healthy individuals.

AB - Background: Restless Legs Syndrome (RLS) is characterized by uncomfortable nocturnal sensations in the legs making sedentary activities and sleep difficult, and is thus linked with psychosocial distress. Due to the symptomatology and neurobiology of RLS (disrupting brain iron and dopamine) it is likely that RLS associates with poorer health-related quality of life (HRQL) and depressive disorder. The objective of this study was to investigate the RLS-HRQL and the RLS-depressive disorder links in a generally healthy population that is not biased by medications. Methods: Complete data, including the Cambridge–Hopkins RLS questionnaire, the 12-item short-form standardized health survey (SF-12), the Major Depression Inventory (MDI), body mass index, smoking status, alcohol consumption, and education were available for 24,707 participants enrolled in the Danish Blood Donor Study from May 1, 2015 to February 1, 2017. Information on quality of sleep was available for all RLS cases. T-tests and multivariable logistic regression models were applied to examine the associations of RLS and MDI scores, and the physical and mental component scores (PCS and MCS) of SF-12, respectively. Analyses were conducted separately for men and women. Results: RLS associated with poorer MCS and poorer PCS. Moreover, Participants with RLS were more likely to classify with depressive disorder. Poor quality of sleep was associated with depressive disorder and poorer MCS among RLS cases, and with poorer PCS in female RLS cases. Conclusion: Thus, we demonstrated that RLS is associated with a significantly lower HRQL and a higher prevalence of depressive disorder among otherwise healthy individuals.

KW - Comorbidities

KW - Depressive disorder

KW - Quality of life

KW - Restless legs syndrome

KW - Sleep disturbance

KW - The Danish blood donor study

UR - https://www.scopus.com/pages/publications/85044991695

U2 - 10.1016/j.sleep.2018.02.007

DO - 10.1016/j.sleep.2018.02.007

M3 - Article

C2 - 29680420

AN - SCOPUS:85044991695

SN - 1389-9457

VL - 45

SP - 124

EP - 131

JO - Sleep Medicine

JF - Sleep Medicine

ER -

Restless legs syndrome is associated with major comorbidities in a population of Danish blood donors

Abstract

Funding

Keywords

Access to Document

Other files and links

Fingerprint

Cite this