Reporting on circulating tumor DNA monitoring in metastatic cancer-From clinical validity to clinical utility

Caroline Brenner Thomsen; Amanda Dandanell Juul; Anna Cecilie Lefèvre; Christina Glismand Truelsen; Edina Dizdarevic; Heidi Ryssel; Ina Mathilde Kjaer; Karen Lycke Wind; Louise Bach Callesen; Louise Faaborg Larsen; Malene Støchkel Frank; Rikke Fredslund Andersen; Karen-Lise Garm Spindler; Anders Jakobsen

doi:10.1002/cncr.34168

Reporting on circulating tumor DNA monitoring in metastatic cancer-From clinical validity to clinical utility

Caroline Brenner Thomsen^*
, Amanda Dandanell Juul
, Anna Cecilie Lefèvre
, Christina Glismand Truelsen
, Edina Dizdarevic
, Heidi Ryssel
, Ina Mathilde Kjaer
, Karen Lycke Wind
, Louise Bach Callesen
, Louise Faaborg Larsen
, Malene Støchkel Frank
, Rikke Fredslund Andersen
, Karen-Lise Garm Spindler
, Anders Jakobsen

^*Corresponding author for this work

Oncology

Research output: Contribution to journal › Comment/debate › Research

Abstract

This commentary attempts to discuss the required standardization of circulating tumor DNA (ctDNA) analyses and thereby improve the clinical validity of ctDNA monitoring in the metastatic setting of solid tumors.

Original language	English
Pages (from-to)	2052-2057
Number of pages	6
Journal	Cancer
Volume	128
Issue number	11
Early online date	18 Mar 2022
DOIs	https://doi.org/10.1002/cncr.34168
Publication status	Published - 1 Jun 2022

Keywords

circulating tumor DNA (ctDNA)
clinical utility
metastatic cancer
monitoring
reporting on circulating tumor DNA
standardization
Circulating Tumor DNA/genetics
Neoplasms, Second Primary
Humans
Mutation
Neoplasms/genetics
Biomarkers, Tumor/genetics

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10.1002/cncr.34168

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Brenner Thomsen, C., Dandanell Juul, A., Lefèvre, A. C., Glismand Truelsen, C., Dizdarevic, E., Ryssel, H., Mathilde Kjaer, I., Lycke Wind, K., Callesen, L. B., Faaborg Larsen, L., Støchkel Frank, M., Fredslund Andersen, R., Garm Spindler, K.-L., & Jakobsen, A. (2022). Reporting on circulating tumor DNA monitoring in metastatic cancer-From clinical validity to clinical utility. Cancer, 128(11), 2052-2057. https://doi.org/10.1002/cncr.34168

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title = "Reporting on circulating tumor DNA monitoring in metastatic cancer-From clinical validity to clinical utility",

abstract = "This commentary attempts to discuss the required standardization of circulating tumor DNA (ctDNA) analyses and thereby improve the clinical validity of ctDNA monitoring in the metastatic setting of solid tumors.",

keywords = "circulating tumor DNA (ctDNA), clinical utility, metastatic cancer, monitoring, reporting on circulating tumor DNA, standardization, Circulating Tumor DNA/genetics, Neoplasms, Second Primary, Humans, Mutation, Neoplasms/genetics, Biomarkers, Tumor/genetics",

author = "\{Brenner Thomsen\}, Caroline and \{Dandanell Juul\}, Amanda and Lef{\`e}vre, \{Anna Cecilie\} and \{Glismand Truelsen\}, Christina and Edina Dizdarevic and Heidi Ryssel and \{Mathilde Kjaer\}, Ina and \{Lycke Wind\}, Karen and Callesen, \{Louise Bach\} and \{Faaborg Larsen\}, Louise and \{St{\o}chkel Frank\}, Malene and \{Fredslund Andersen\}, Rikke and \{Garm Spindler\}, Karen-Lise and Anders Jakobsen",

year = "2022",

month = jun,

day = "1",

doi = "10.1002/cncr.34168",

language = "English",

volume = "128",

pages = "2052--2057",

journal = "Cancer",

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publisher = "John Wiley \& Sons Inc.",

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Brenner Thomsen, C, Dandanell Juul, A, Lefèvre, AC, Glismand Truelsen, C, Dizdarevic, E, Ryssel, H, Mathilde Kjaer, I, Lycke Wind, K, Callesen, LB, Faaborg Larsen, L, Støchkel Frank, M, Fredslund Andersen, R, Garm Spindler, K-L & Jakobsen, A 2022, 'Reporting on circulating tumor DNA monitoring in metastatic cancer-From clinical validity to clinical utility', Cancer, vol. 128, no. 11, pp. 2052-2057. https://doi.org/10.1002/cncr.34168

TY - JOUR

T1 - Reporting on circulating tumor DNA monitoring in metastatic cancer-From clinical validity to clinical utility

AU - Brenner Thomsen, Caroline

AU - Dandanell Juul, Amanda

AU - Lefèvre, Anna Cecilie

AU - Glismand Truelsen, Christina

AU - Dizdarevic, Edina

AU - Ryssel, Heidi

AU - Mathilde Kjaer, Ina

AU - Lycke Wind, Karen

AU - Callesen, Louise Bach

AU - Faaborg Larsen, Louise

AU - Støchkel Frank, Malene

AU - Fredslund Andersen, Rikke

AU - Garm Spindler, Karen-Lise

AU - Jakobsen, Anders

PY - 2022/6/1

Y1 - 2022/6/1

N2 - This commentary attempts to discuss the required standardization of circulating tumor DNA (ctDNA) analyses and thereby improve the clinical validity of ctDNA monitoring in the metastatic setting of solid tumors.

AB - This commentary attempts to discuss the required standardization of circulating tumor DNA (ctDNA) analyses and thereby improve the clinical validity of ctDNA monitoring in the metastatic setting of solid tumors.

KW - circulating tumor DNA (ctDNA)

KW - clinical utility

KW - metastatic cancer

KW - monitoring

KW - reporting on circulating tumor DNA

KW - standardization

KW - Circulating Tumor DNA/genetics

KW - Neoplasms, Second Primary

KW - Humans

KW - Mutation

KW - Neoplasms/genetics

KW - Biomarkers, Tumor/genetics

U2 - 10.1002/cncr.34168

DO - 10.1002/cncr.34168

M3 - Comment/debate

C2 - 35302663

SN - 0008-543X

VL - 128

SP - 2052

EP - 2057

JO - Cancer

JF - Cancer

IS - 11

ER -

Reporting on circulating tumor DNA monitoring in metastatic cancer-From clinical validity to clinical utility

Abstract

Keywords

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