Overlapping DNA methylation changes in enhancers in clonal cytopenia of undetermined significance and myelodysplastic neoplasm patients with TET2, IDH2, or DNMT3A mutations

Katja Kaastrup; Morten Tulstrup; Jakob W Hansen; Claudia Schöllkopf; Klas Raaschou-Jensen; Andreas D Ørskov; Bo Porse; Peter A Jones; Joachim Weischenfeldt; Linn Gillberg; Kirsten Grønbæk

doi:10.3324/haematol.2024.285466

Overlapping DNA methylation changes in enhancers in clonal cytopenia of undetermined significance and myelodysplastic neoplasm patients with TET2, IDH2, or DNMT3A mutations

Katja Kaastrup
, Morten Tulstrup
, Jakob W Hansen
, Claudia Schöllkopf
, Klas Raaschou-Jensen
, Andreas D Ørskov
, Bo Porse
, Peter A Jones
, Joachim Weischenfeldt
, Linn Gillberg
, Kirsten Grønbæk^*

^*Corresponding author for this work

Haematology

Research output: Contribution to journal › Letter › Research › peer-review

Abstract

Not available.

Original language	English
Pages (from-to)	1164-1169
Number of pages	6
Journal	Haematologica
Volume	110
Issue number	5
Early online date	2 Jan 2025
DOIs	https://doi.org/10.3324/haematol.2024.285466
Publication status	Published - 1 May 2025

Funding

The study is part of the Danish Research Center for Precision Medicine in Blood Cancers funded by the Danish Cancer Society grant number R223-A13071 and was supported by a Center grant from the Novo Nordisk Foundation (Novo Nordisk Foundation Centre for Stem Cell Biology, Dan Stem; grant number NNF17CC0027852) and Greater Copenhagen Health Science Partners, and through a grant from Dansk Kraeftforskningsfond. KK was supported by a 1 -year grant from the University of Copenhagen.

Funders	Funder number
Danish Cancer Society	R223-A13071
Novo Nordisk Foundation	NNF17CC0027852
Greater Copenhagen Health Science Partners, Clinical Academic Group Prognostication of Acute Recovery Capacity - in an Aging Population
Danish Foundation for Clinical and Experimental Cancer Research
University of Copenhagen

Keywords

Mutations

Access to Document

10.3324/haematol.2024.285466

Cite this

Kaastrup, K., Tulstrup, M., Hansen, J. W., Schöllkopf, C., Raaschou-Jensen, K., Ørskov, A. D., Porse, B., Jones, P. A., Weischenfeldt, J., Gillberg, L., & Grønbæk, K. (2025). Overlapping DNA methylation changes in enhancers in clonal cytopenia of undetermined significance and myelodysplastic neoplasm patients with TET2, IDH2, or DNMT3A mutations. Haematologica, 110(5), 1164-1169. https://doi.org/10.3324/haematol.2024.285466

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title = "Overlapping DNA methylation changes in enhancers in clonal cytopenia of undetermined significance and myelodysplastic neoplasm patients with TET2, IDH2, or DNMT3A mutations",

abstract = "Not available.",

keywords = "Mutations",

author = "Katja Kaastrup and Morten Tulstrup and Hansen, \{Jakob W\} and Claudia Sch{\"o}llkopf and Klas Raaschou-Jensen and {\O}rskov, \{Andreas D\} and Bo Porse and Jones, \{Peter A\} and Joachim Weischenfeldt and Linn Gillberg and Kirsten Gr{\o}nb{\ae}k",

year = "2025",

month = may,

day = "1",

doi = "10.3324/haematol.2024.285466",

language = "English",

volume = "110",

pages = "1164--1169",

journal = "Haematologica",

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Kaastrup, K, Tulstrup, M, Hansen, JW, Schöllkopf, C, Raaschou-Jensen, K, Ørskov, AD, Porse, B, Jones, PA, Weischenfeldt, J, Gillberg, L & Grønbæk, K 2025, 'Overlapping DNA methylation changes in enhancers in clonal cytopenia of undetermined significance and myelodysplastic neoplasm patients with TET2, IDH2, or DNMT3A mutations', Haematologica, vol. 110, no. 5, pp. 1164-1169. https://doi.org/10.3324/haematol.2024.285466

Overlapping DNA methylation changes in enhancers in clonal cytopenia of undetermined significance and myelodysplastic neoplasm patients with TET2, IDH2, or DNMT3A mutations. / Kaastrup, Katja; Tulstrup, Morten; Hansen, Jakob W et al.
In: Haematologica, Vol. 110, No. 5, 01.05.2025, p. 1164-1169.

Research output: Contribution to journal › Letter › Research › peer-review

TY - JOUR

T1 - Overlapping DNA methylation changes in enhancers in clonal cytopenia of undetermined significance and myelodysplastic neoplasm patients with TET2, IDH2, or DNMT3A mutations

AU - Kaastrup, Katja

AU - Tulstrup, Morten

AU - Hansen, Jakob W

AU - Schöllkopf, Claudia

AU - Raaschou-Jensen, Klas

AU - Ørskov, Andreas D

AU - Porse, Bo

AU - Jones, Peter A

AU - Weischenfeldt, Joachim

AU - Gillberg, Linn

AU - Grønbæk, Kirsten

PY - 2025/5/1

Y1 - 2025/5/1

N2 - Not available.

AB - Not available.

KW - Mutations

U2 - 10.3324/haematol.2024.285466

DO - 10.3324/haematol.2024.285466

M3 - Letter

C2 - 39744828

SN - 0390-6078

VL - 110

SP - 1164

EP - 1169

JO - Haematologica

JF - Haematologica

IS - 5

ER -

Overlapping DNA methylation changes in enhancers in clonal cytopenia of undetermined significance and myelodysplastic neoplasm patients with TET2, IDH2, or DNMT3A mutations

Abstract

Funding

Keywords

Access to Document

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