Optimizing clinical performance and geometrical robustness of a new electrode device for intracranial tumor electroporation

Faisal Mahmood; Julie Gehl

doi:10.1016/j.bioelechem.2010.12.002

Optimizing clinical performance and geometrical robustness of a new electrode device for intracranial tumor electroporation

Faisal Mahmood
, Julie Gehl^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

Abstract

Current technology has limited applicability for electroporation based treatment of deep-seated tumors, and is in general, not optimized in terms of compliance with clinically relevant parameters. Here we present a novel electrode device developed for electrotransfer of antineoplastic drugs and genes to intracranial tumors in humans, and demonstrate a method to optimize the design (i.e. geometry) of the electrode device prototype to improve both clinical performance and geometrical tolerance (robustness). We have employed a semiempirical objective function based on constraints similar to those used in radiation oncology. The results show that small geometrical changes may yield a significant improvement. For example, a 2. mm displacement of 6 electrodes yields 14% better compliance with the clinical parameters, compared to the prototype, and additionally makes the electrode device less sensitive to random geometrical deviations. The method is readily applicable to other electrode configurations.

Original language	English
Pages (from-to)	10-16
Number of pages	7
Journal	Bioelectrochemistry
Volume	81
Issue number	1
DOIs	https://doi.org/10.1016/j.bioelechem.2010.12.002
Publication status	Published - 1 Apr 2011

Funding

This work was supported by grants from the Danish National Advanced Technology Foundation . Thanks to our colleagues for the inspiring discussions and proofreading, especially J.M. Edmund, M. Linnert and T.H. Sørensen. Julie Gehl is an MD and Oncologist. The focus of interest in research is cell electroporation to enhance uptake of drugs and genes. She defended her doctorate thesis at the University of Copenhagen on this topic and continued to form the Center for Experimental Drug and Gene Electrotransfer (C*EDGE), which is a multidisciplinary group working with in vitro, in vivo and clinical studies on the optimization of drug and gene delivery by electrotransfer. She is a Clinical Associate Research Professor at the University of Copenhagen and a research fellow of the Royal Swedish Academy of Sciences, supported by the Acta Oncologica Foundation.

Keywords

Brain tumor
Electrode device
Electroporation
Geometrical robustness
Optimization
Treatment planning

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10.1016/j.bioelechem.2010.12.002

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abstract = "Current technology has limited applicability for electroporation based treatment of deep-seated tumors, and is in general, not optimized in terms of compliance with clinically relevant parameters. Here we present a novel electrode device developed for electrotransfer of antineoplastic drugs and genes to intracranial tumors in humans, and demonstrate a method to optimize the design (i.e. geometry) of the electrode device prototype to improve both clinical performance and geometrical tolerance (robustness). We have employed a semiempirical objective function based on constraints similar to those used in radiation oncology. The results show that small geometrical changes may yield a significant improvement. For example, a 2. mm displacement of 6 electrodes yields 14\% better compliance with the clinical parameters, compared to the prototype, and additionally makes the electrode device less sensitive to random geometrical deviations. The method is readily applicable to other electrode configurations.",

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AB - Current technology has limited applicability for electroporation based treatment of deep-seated tumors, and is in general, not optimized in terms of compliance with clinically relevant parameters. Here we present a novel electrode device developed for electrotransfer of antineoplastic drugs and genes to intracranial tumors in humans, and demonstrate a method to optimize the design (i.e. geometry) of the electrode device prototype to improve both clinical performance and geometrical tolerance (robustness). We have employed a semiempirical objective function based on constraints similar to those used in radiation oncology. The results show that small geometrical changes may yield a significant improvement. For example, a 2. mm displacement of 6 electrodes yields 14% better compliance with the clinical parameters, compared to the prototype, and additionally makes the electrode device less sensitive to random geometrical deviations. The method is readily applicable to other electrode configurations.

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Optimizing clinical performance and geometrical robustness of a new electrode device for intracranial tumor electroporation

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Keywords

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