Neo-antigen specific memory T-cell responses in healthy individuals

Morten Orebo Holmström; Hans Carl Hasselbalch; Mads Hald Andersen

doi:10.1080/2162402X.2019.1599640

Neo-antigen specific memory T-cell responses in healthy individuals

Morten Orebo Holmström^*
, Hans Carl Hasselbalch
, Mads Hald Andersen

^*Corresponding author for this work

Haematology

Research output: Contribution to journal › Editorial › Research › peer-review

Abstract

The driver mutations in exon 9 of the calreticulin protein have only been identified in patients with myeloid cancers. We recently demonstrated that healthy individuals display strong and frequent T-cell responses towards this mutation. This memory T-cell response is likely evidence of the elimination of mutated cells in healthy individuals.

Original language	English
Pages (from-to)	1599640
Journal	OncoImmunology
Volume	8
Issue number	7
DOIs	https://doi.org/10.1080/2162402X.2019.1599640
Publication status	Published - 31 May 2019

Keywords

Neoantigens
memory T-cells
calreticulin
hematological cancer
cancer immunoediting

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10.1080/2162402X.2019.1599640

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title = "Neo-antigen specific memory T-cell responses in healthy individuals",

abstract = "The driver mutations in exon 9 of the calreticulin protein have only been identified in patients with myeloid cancers. We recently demonstrated that healthy individuals display strong and frequent T-cell responses towards this mutation. This memory T-cell response is likely evidence of the elimination of mutated cells in healthy individuals.",

keywords = "Neoantigens, memory T-cells, calreticulin, hematological cancer, cancer immunoediting",

author = "Holmstr{\"o}m, \{Morten Orebo\} and Hasselbalch, \{Hans Carl\} and Andersen, \{Mads Hald\}",

year = "2019",

month = may,

day = "31",

doi = "10.1080/2162402X.2019.1599640",

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T1 - Neo-antigen specific memory T-cell responses in healthy individuals

AU - Holmström, Morten Orebo

AU - Hasselbalch, Hans Carl

AU - Andersen, Mads Hald

PY - 2019/5/31

Y1 - 2019/5/31

N2 - The driver mutations in exon 9 of the calreticulin protein have only been identified in patients with myeloid cancers. We recently demonstrated that healthy individuals display strong and frequent T-cell responses towards this mutation. This memory T-cell response is likely evidence of the elimination of mutated cells in healthy individuals.

AB - The driver mutations in exon 9 of the calreticulin protein have only been identified in patients with myeloid cancers. We recently demonstrated that healthy individuals display strong and frequent T-cell responses towards this mutation. This memory T-cell response is likely evidence of the elimination of mutated cells in healthy individuals.

KW - Neoantigens

KW - memory T-cells

KW - calreticulin

KW - hematological cancer

KW - cancer immunoediting

U2 - 10.1080/2162402X.2019.1599640

DO - 10.1080/2162402X.2019.1599640

M3 - Editorial

C2 - 31143522

SN - 2162-4011

VL - 8

SP - 1599640

JO - OncoImmunology

JF - OncoImmunology

IS - 7

ER -

Neo-antigen specific memory T-cell responses in healthy individuals

Abstract

Keywords

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