Myocardial Na,K-ATPase and digoxin therapy in human heart failure

Keld Kjeldsen; Henning Bundgaard

doi:10.1111/j.1749-6632.2003.tb07285.x

Myocardial Na,K-ATPase and digoxin therapy in human heart failure

Keld Kjeldsen^*
, Henning Bundgaard

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

Abstract

The specific binding of digitalis glycosides to the Na,K-ATPase is used as a tool for Na,K-ATPase quantification with high accuracy and precision. In myocardial biopsies from patients with heart failure, total Na,K-ATPase concentration is decreased, and the decrease in Na,K-ATPase concentration correlates with a decrease in heart function. During digitalization, a fraction of remaining pumps are occupied by digoxin. No evidence for an endogenous digitalis-like factor of any clinical importance was obtained. It is recommended that digoxin be administered to heart failure patients who still have dyspnea after institution of mortality-reducing therapy.

Original language	English
Pages (from-to)	702-707
Number of pages	6
Journal	Annals of the New York Academy of Sciences
Volume	986
DOIs	https://doi.org/10.1111/j.1749-6632.2003.tb07285.x
Publication status	Published - 1 Jan 2003

Keywords

Digoxin
Heart failure
Na,K-ATPase

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abstract = "The specific binding of digitalis glycosides to the Na,K-ATPase is used as a tool for Na,K-ATPase quantification with high accuracy and precision. In myocardial biopsies from patients with heart failure, total Na,K-ATPase concentration is decreased, and the decrease in Na,K-ATPase concentration correlates with a decrease in heart function. During digitalization, a fraction of remaining pumps are occupied by digoxin. No evidence for an endogenous digitalis-like factor of any clinical importance was obtained. It is recommended that digoxin be administered to heart failure patients who still have dyspnea after institution of mortality-reducing therapy.",

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AU - Bundgaard, Henning

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N2 - The specific binding of digitalis glycosides to the Na,K-ATPase is used as a tool for Na,K-ATPase quantification with high accuracy and precision. In myocardial biopsies from patients with heart failure, total Na,K-ATPase concentration is decreased, and the decrease in Na,K-ATPase concentration correlates with a decrease in heart function. During digitalization, a fraction of remaining pumps are occupied by digoxin. No evidence for an endogenous digitalis-like factor of any clinical importance was obtained. It is recommended that digoxin be administered to heart failure patients who still have dyspnea after institution of mortality-reducing therapy.

AB - The specific binding of digitalis glycosides to the Na,K-ATPase is used as a tool for Na,K-ATPase quantification with high accuracy and precision. In myocardial biopsies from patients with heart failure, total Na,K-ATPase concentration is decreased, and the decrease in Na,K-ATPase concentration correlates with a decrease in heart function. During digitalization, a fraction of remaining pumps are occupied by digoxin. No evidence for an endogenous digitalis-like factor of any clinical importance was obtained. It is recommended that digoxin be administered to heart failure patients who still have dyspnea after institution of mortality-reducing therapy.

KW - Digoxin

KW - Heart failure

KW - Na,K-ATPase

UR - https://www.scopus.com/pages/publications/0037564210

U2 - 10.1111/j.1749-6632.2003.tb07285.x

DO - 10.1111/j.1749-6632.2003.tb07285.x

M3 - Article

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AN - SCOPUS:0037564210

SN - 0077-8923

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SP - 702

EP - 707

JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

ER -

Myocardial Na,K-ATPase and digoxin therapy in human heart failure

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Keywords

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