Molecular population genetic analysis of Campylobacter jejuni HS:19 associated with Guillain-Barré syndrome and gastroenteritis

Irving Nachamkin; Jørgen Engberg; Michaela Gutacker; Richard J. Meinersman; Chun Yan Li; Patricia Arzate; Erin Teeple; Vivian Fussing; Tony W. Ho; Arthur K. Asbury; John W. Griffin; Guy M. McKhann; Jean Claude Piffaretti

doi:10.1086/322008

Molecular population genetic analysis of Campylobacter jejuni HS:19 associated with Guillain-Barré syndrome and gastroenteritis

Irving Nachamkin
, Jørgen Engberg
, Michaela Gutacker
, Richard J. Meinersman
, Chun Yan Li
, Patricia Arzate
, Erin Teeple
, Vivian Fussing
, Tony W. Ho
, Arthur K. Asbury
, John W. Griffin
, Guy M. McKhann
, Jean Claude Piffaretti

Research output: Contribution to journal › Article › Research › peer-review

Abstract

Infection with Campylobacter jejuni serotype HS:19 is associated with the development of Guillain-Barré syndrome (GBS). To determine whether a particular HS:19 clone is associated with GBS, multilocus enzyme electrophoresis (MLEE) was used to analyze a worldwide collection of isolates. There were 34 electropherotypes (ETs) in 3 phylogenetic clusters among 83 C. jejuni isolates. Cluster I contained all HS:19 strains, and a single ET (ET4) accounted for most HS:19 strains. HS:19 strains did not occur in any of the other clusters. ET4 contained isolates from different geographic locations, indicating global spread of this clone. Furthermore, ET4 contained isolates from patients with uncomplicated enteritis and GBS, as well as isolates from animal sources. The results of this study show that HS:19 strains comprise a clonal, although not monomorphic, population, which is distinct from non-HS:19 strains within C. jejuni. A unique clone associated with GBS was not identified by use of MLEE.

Original language	English
Pages (from-to)	221-226
Number of pages	6
Journal	Journal of Infectious Diseases
Volume	184
Issue number	2
DOIs	https://doi.org/10.1086/322008
Publication status	Published - 15 Jul 2001

Funding

Financial support: National Institutes of Health (NS-31528 to G.M.M., J.W.G., and I.N.); Swiss National Science Foundation (31-45914,95 to J.-C.P.).

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10.1086/322008

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Nachamkin, I., Engberg, J., Gutacker, M., Meinersman, R. J., Li, C. Y., Arzate, P., Teeple, E., Fussing, V., Ho, T. W., Asbury, A. K., Griffin, J. W., McKhann, G. M., & Piffaretti, J. C. (2001). Molecular population genetic analysis of Campylobacter jejuni HS:19 associated with Guillain-Barré syndrome and gastroenteritis. Journal of Infectious Diseases, 184(2), 221-226. https://doi.org/10.1086/322008

@article{e08c884164ce43cbab4254dbbab75ea4,

title = "Molecular population genetic analysis of Campylobacter jejuni HS:19 associated with Guillain-Barr{\'e} syndrome and gastroenteritis",

abstract = "Infection with Campylobacter jejuni serotype HS:19 is associated with the development of Guillain-Barr{\'e} syndrome (GBS). To determine whether a particular HS:19 clone is associated with GBS, multilocus enzyme electrophoresis (MLEE) was used to analyze a worldwide collection of isolates. There were 34 electropherotypes (ETs) in 3 phylogenetic clusters among 83 C. jejuni isolates. Cluster I contained all HS:19 strains, and a single ET (ET4) accounted for most HS:19 strains. HS:19 strains did not occur in any of the other clusters. ET4 contained isolates from different geographic locations, indicating global spread of this clone. Furthermore, ET4 contained isolates from patients with uncomplicated enteritis and GBS, as well as isolates from animal sources. The results of this study show that HS:19 strains comprise a clonal, although not monomorphic, population, which is distinct from non-HS:19 strains within C. jejuni. A unique clone associated with GBS was not identified by use of MLEE.",

author = "Irving Nachamkin and J{\o}rgen Engberg and Michaela Gutacker and Meinersman, \{Richard J.\} and Li, \{Chun Yan\} and Patricia Arzate and Erin Teeple and Vivian Fussing and Ho, \{Tony W.\} and Asbury, \{Arthur K.\} and Griffin, \{John W.\} and McKhann, \{Guy M.\} and Piffaretti, \{Jean Claude\}",

year = "2001",

month = jul,

day = "15",

doi = "10.1086/322008",

language = "English",

volume = "184",

pages = "221--226",

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publisher = "Oxford University Press",

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Nachamkin, I, Engberg, J, Gutacker, M, Meinersman, RJ, Li, CY, Arzate, P, Teeple, E, Fussing, V, Ho, TW, Asbury, AK, Griffin, JW, McKhann, GM & Piffaretti, JC 2001, 'Molecular population genetic analysis of Campylobacter jejuni HS:19 associated with Guillain-Barré syndrome and gastroenteritis', Journal of Infectious Diseases, vol. 184, no. 2, pp. 221-226. https://doi.org/10.1086/322008

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T1 - Molecular population genetic analysis of Campylobacter jejuni HS:19 associated with Guillain-Barré syndrome and gastroenteritis

AU - Nachamkin, Irving

AU - Engberg, Jørgen

AU - Gutacker, Michaela

AU - Meinersman, Richard J.

AU - Li, Chun Yan

AU - Arzate, Patricia

AU - Teeple, Erin

AU - Fussing, Vivian

AU - Ho, Tony W.

AU - Asbury, Arthur K.

AU - Griffin, John W.

AU - McKhann, Guy M.

AU - Piffaretti, Jean Claude

PY - 2001/7/15

Y1 - 2001/7/15

N2 - Infection with Campylobacter jejuni serotype HS:19 is associated with the development of Guillain-Barré syndrome (GBS). To determine whether a particular HS:19 clone is associated with GBS, multilocus enzyme electrophoresis (MLEE) was used to analyze a worldwide collection of isolates. There were 34 electropherotypes (ETs) in 3 phylogenetic clusters among 83 C. jejuni isolates. Cluster I contained all HS:19 strains, and a single ET (ET4) accounted for most HS:19 strains. HS:19 strains did not occur in any of the other clusters. ET4 contained isolates from different geographic locations, indicating global spread of this clone. Furthermore, ET4 contained isolates from patients with uncomplicated enteritis and GBS, as well as isolates from animal sources. The results of this study show that HS:19 strains comprise a clonal, although not monomorphic, population, which is distinct from non-HS:19 strains within C. jejuni. A unique clone associated with GBS was not identified by use of MLEE.

AB - Infection with Campylobacter jejuni serotype HS:19 is associated with the development of Guillain-Barré syndrome (GBS). To determine whether a particular HS:19 clone is associated with GBS, multilocus enzyme electrophoresis (MLEE) was used to analyze a worldwide collection of isolates. There were 34 electropherotypes (ETs) in 3 phylogenetic clusters among 83 C. jejuni isolates. Cluster I contained all HS:19 strains, and a single ET (ET4) accounted for most HS:19 strains. HS:19 strains did not occur in any of the other clusters. ET4 contained isolates from different geographic locations, indicating global spread of this clone. Furthermore, ET4 contained isolates from patients with uncomplicated enteritis and GBS, as well as isolates from animal sources. The results of this study show that HS:19 strains comprise a clonal, although not monomorphic, population, which is distinct from non-HS:19 strains within C. jejuni. A unique clone associated with GBS was not identified by use of MLEE.

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DO - 10.1086/322008

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SN - 0022-1899

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JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 2

ER -

Molecular population genetic analysis of Campylobacter jejuni HS:19 associated with Guillain-Barré syndrome and gastroenteritis

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