TY - JOUR
T1 - Methylphenidate for attention deficit hyperactivity disorder (ADHD) in children and adolescents
T2 - assessment of adverse events in non‐randomised studies
AU - Storebø, Ole Jakob
AU - Pedersen, Nadia
AU - Ramstad, Erica
AU - Kielsholm, Maja Lærke
AU - Nielsen, Signe Sofie
AU - Krogh, Helle B.
AU - Moreira‐Maia, Carlos R.
AU - Magnusson, Frederik L.
AU - Holmskov, Mathilde
AU - Gerner, Trine
AU - Skoog, Maria
AU - Rosendal, Susanne
AU - Groth, Camilla
AU - Gillies, Donna
AU - Rasmussen, Kirsten Buch
AU - Gauci, Dorothy
AU - Zwi, Morris
AU - Kirubakaran, Richard
AU - Håkonsen, Sasja J.
AU - Aagaard, Lise
AU - Simonsen, Erik
AU - Gluud, Christian
PY - 2018
Y1 - 2018
N2 - Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder in childhood. The psychostimulant methylphenidate is the most frequently used medication to treat it. Several studies have investigated the benefits of methylphenidate, showing possible favourable effects on ADHD symptoms, but the true magnitude of the effect is unknown. Concerning adverse events associated with the treatment, our systematic review of randomised clinical trials (RCTs) demonstrated no increase in serious adverse events, but a high proportion of participants suffered a range of non‐serious adverse events.
AB - Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder in childhood. The psychostimulant methylphenidate is the most frequently used medication to treat it. Several studies have investigated the benefits of methylphenidate, showing possible favourable effects on ADHD symptoms, but the true magnitude of the effect is unknown. Concerning adverse events associated with the treatment, our systematic review of randomised clinical trials (RCTs) demonstrated no increase in serious adverse events, but a high proportion of participants suffered a range of non‐serious adverse events.
U2 - 10.1002/14651858.CD012069.pub2
DO - 10.1002/14651858.CD012069.pub2
M3 - Review
SN - 1465-1858
VL - 2018
JO - Cochrane Database of Systematic Reviews
JF - Cochrane Database of Systematic Reviews
IS - 5
M1 - CD012069
ER -