Measuring quality of life in first-episode psychosis

I. Melle*, S. Friis, U. Haahr, J. O. Johannesen, T. K. Larsen, S. Opjordsmoen, J. I. Roessberg, B. R. Rund, E. Simonsen, P. Vaglum, T. McGlashan

*Corresponding author for this work

    Research output: Contribution to journalArticleResearchpeer-review


    Quality of life (QoL) measures are increasingly recognized as necessary parts of outcome assessments in psychosis. The present paper is a comprehensive study of patients with first-episode psychosis where QoL is measured by the commonly used Lehman Quality of Life Interview (L-QoLI). The aim is to examine if the L-QoLI maintain its original structure when used in a group of patients with first-episode psychosis, and to investigate what determines global subjective QoL with a specific emphasis on premorbid adjustment, duration of untreated psychosis (DUP) and clinical symptoms. The study indicates that the psychometric properties of the L-QoLI do not change significantly when used in first-episode samples. The patients report subjective and objective QoL in the fair to good range, with only a moderate association between the objective and subjective measures. Poor global satisfaction is predicted by being single, abusing drugs, being depressed, having a diagnosis of psychotic affective disorder, having poor premorbid social adjustment and DUP over 10:weeks. The study supports the notion that patients with first-episode psychosis construct QoL in the same way as other groups, and that longer durations of compromised function at this stage produces poor satisfaction with life rather than a downward readjustment of expectations.

    Original languageEnglish
    Pages (from-to)474-483
    Number of pages10
    JournalEuropean Psychiatry
    Issue number7
    Publication statusPublished - Nov 2005


    • Affective psychosis
    • First-episode psychosis
    • Premorbid adjustment
    • Quality of life
    • Schizophrenia


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