Abstract
Secretory carcinoma, originally described as mammary analog secretory carcinoma (MASC), is a low-grade salivary gland tumor characterized by a t(12;15)(p13;q25) translocation, resulting in an ETV6-NTRK3 gene fusion. Most MASCs are localized to the parotid gland and intraoral minor salivary glands. Moreover, ETV6-rearranged carcinomas with secretory features have been reported recently in the thyroid (with and without a history of radiation exposure), skin, and in very rare instances in the sinonasal tract. Here, we describe 2 cases of primary MASC in the sinonasal tract and provide a detailed clinical and histopathologic characterization of their morphology, immunohistochemical profile, and genetic background and highlight features allowing for its separation from its recently described molecular mimicker, ETV6-rearranged low-grade sinonasal adenocarcinoma.
| Original language | English |
|---|---|
| Pages (from-to) | 735-743 |
| Number of pages | 9 |
| Journal | American Journal of Surgical Pathology |
| Volume | 42 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 1 Jan 2018 |
Funding
Conflicts of Interest and Source of Funding: Supported by the National Sustainability Program I (NPU I) Nr. LO1503 and by the grant SVV– 2017 No. 260 391 provided by the Ministry of Education, Youth and Sports of the Czech Republic. The authors have disclosed that they have no significant relationships with, or financial interest in, any commercial companies pertaining to this article.
Keywords
- ETV6-NTRK3
- low-grade sinonasal adenocarcinoma
- mammary analog secretory carcinoma
- MASC
- Nasal cavity
Fingerprint
Explore the research areas of 'Mammary Analog Secretory Carcinoma of the Nasal Cavity'.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver