Left Ventricular Hypertrophy in Women With a History of Preeclampsia

Maria G Hauge; Peter Damm; Klaus F Kofoed; Emma Louise Ries Møller; Andrea G Lopez; Anne S Ersbøll; Marianne Johansen; Per E Sigvardsen; Michael H C Pham; Jens P Goetze; Andreas Fuchs; Jørgen T Kühl; Børge G Nordestgaard; Lars V Køber; Finn Gustafsson; Jesper J Linde

doi:10.1161/HYPERTENSIONAHA.124.23497

Left Ventricular Hypertrophy in Women With a History of Preeclampsia

Maria G Hauge^*
, Peter Damm
, Klaus F Kofoed
, Emma Louise Ries Møller
, Andrea G Lopez
, Anne S Ersbøll
, Marianne Johansen
, Per E Sigvardsen
, Michael H C Pham
, Jens P Goetze
, Andreas Fuchs
, Jørgen T Kühl
, Børge G Nordestgaard
, Lars V Køber
, Finn Gustafsson
, Jesper J Linde

^*Corresponding author for this work

Cardiology

Research output: Contribution to journal › Article › Research › peer-review

Abstract

BACKGROUND: As a hypertensive disorder of pregnancy, preeclampsia is associated with increased cardiovascular morbidity and mortality later in life. Since early signs of myocardial affection could indicate a higher risk of future cardiovascular disease manifestations, we investigated whether women with prior preeclampsia have a higher prevalence of left ventricular hypertrophy compared with women from the general population and to what extent chronic hypertension affects any potential difference.

METHODS: In a cohort study, women aged 40 to 55 years with prior preeclampsia were compared with age- and parity-matched women from the general population. They underwent a research cardiac computed tomography, and the primary outcome was left ventricular hypertrophy, defined as a left ventricular mass index >30 g/m2.7.

RESULTS: In 679 women with prior preeclampsia and 672 controls (median age, 47 years), we found a higher prevalence of left ventricular hypertrophy (14.0% versus 6.4%) in the preeclampsia group with an odds ratio of 1.62, 95% CI (1.07-2.46), P=0.024, median of 15 years (range, 0-28) after pregnancy, after adjustment for cardiovascular risk factors, including chronic hypertension. Left ventricular hypertrophy was more frequent among women with preeclampsia with (26.2% versus 15.6%) and without (5.5% versus 2.4%) chronic hypertension, and a mediation analysis showed that chronic hypertension explained 22% of the association between preeclampsia and left ventricular hypertrophy.

CONCLUSIONS: Women with prior preeclampsia had a 2-fold higher prevalence of left ventricular hypertrophy compared with women from the general population, and preeclampsia was independently associated with left ventricular hypertrophy, regardless of the presence of cardiovascular risk factors, including chronic hypertension.

REGISTRATION: URL: https://www.clinicalTrials.gov; Unique identifier: NCT03949829.

Original language	English
Pages (from-to)	774-783
Number of pages	10
Journal	Hypertension
Volume	82
Issue number	5
Early online date	14 Nov 2024
DOIs	https://doi.org/10.1161/HYPERTENSIONAHA.124.23497
Publication status	Published - May 2025

Funding

The Copenhagen Preeclampsia and Cardiovascular Disease study is funded by the Danish Heart Foundation, Rigshospitalets Forskningspulje, Skibsreder Per Henriksen, R og Hustrus Fond, Kong Christian den Tiendes Fond, Brodrene Hartmanns Fond, Hans og Nora Buchards Fond, Arvid Nilssons Fond, Anita og Tage Therkelsens Fond, Fonden til Laegevidenskabens Fremme, Aase og Ejnar Danielsens Fond, Hjertecentrets Forskningsudvalg (Rigshospitalet), Direktor Kurt Bonnelycke og Hustru Fru Grethe Bonnelyckes Fond, Laegeforeningens Forskningsfond, Helsefondon, Torben & Alice Frimodts Fond, as well as Henry og Astrid Mollers Fond. All the foundations are Danish and have no roles in the study.

Funders
The Danish Heart Foundation
Rigshospitalet
Per Henriksen's Fund
Per Henriksen's Fund
King Christian X's Foundation
Simon Fougner Hartmann Family Fund
Hans and Nora Buchards Foundation
Arvid Nilssons Foundation
Anita and Tage Therkelsen Foundation
Fonden til Lægevidenskabens Fremme
Aase og Ejnar Danielsens Fond
Rigshospitalet
Direktør Kurt Bønnelycke og Hustru Fru Grethe Bønnelyckes Fond
Danish Medical Association Research Foundation
Helsefondon
Torben and Alice Frimodt's Foundation
Henry og Astrid Møllers Fond

Keywords

Adult
Cohort Studies
Female
Humans
Hypertension/epidemiology
Hypertrophy, Left Ventricular/epidemiology
Middle Aged
Pre-Eclampsia/epidemiology
Pregnancy
Prevalence
Risk Factors
Hypertension
Women
Hypertrophy, left ventricular
Preeclampsia
Cardiovascular diseases

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10.1161/HYPERTENSIONAHA.124.23497

Cite this

Hauge, M. G., Damm, P., Kofoed, K. F., Møller, E. L. R., Lopez, A. G., Ersbøll, A. S., Johansen, M., Sigvardsen, P. E., Pham, M. H. C., Goetze, J. P., Fuchs, A., Kühl, J. T., Nordestgaard, B. G., Køber, L. V., Gustafsson, F., & Linde, J. J. (2025). Left Ventricular Hypertrophy in Women With a History of Preeclampsia. Hypertension, 82(5), 774-783. https://doi.org/10.1161/HYPERTENSIONAHA.124.23497

@article{387a1a1c26b343f2acb920200a88e828,

title = "Left Ventricular Hypertrophy in Women With a History of Preeclampsia",

abstract = "BACKGROUND: As a hypertensive disorder of pregnancy, preeclampsia is associated with increased cardiovascular morbidity and mortality later in life. Since early signs of myocardial affection could indicate a higher risk of future cardiovascular disease manifestations, we investigated whether women with prior preeclampsia have a higher prevalence of left ventricular hypertrophy compared with women from the general population and to what extent chronic hypertension affects any potential difference.METHODS: In a cohort study, women aged 40 to 55 years with prior preeclampsia were compared with age- and parity-matched women from the general population. They underwent a research cardiac computed tomography, and the primary outcome was left ventricular hypertrophy, defined as a left ventricular mass index >30 g/m2.7.RESULTS: In 679 women with prior preeclampsia and 672 controls (median age, 47 years), we found a higher prevalence of left ventricular hypertrophy (14.0\% versus 6.4\%) in the preeclampsia group with an odds ratio of 1.62, 95\% CI (1.07-2.46), P=0.024, median of 15 years (range, 0-28) after pregnancy, after adjustment for cardiovascular risk factors, including chronic hypertension. Left ventricular hypertrophy was more frequent among women with preeclampsia with (26.2\% versus 15.6\%) and without (5.5\% versus 2.4\%) chronic hypertension, and a mediation analysis showed that chronic hypertension explained 22\% of the association between preeclampsia and left ventricular hypertrophy.CONCLUSIONS: Women with prior preeclampsia had a 2-fold higher prevalence of left ventricular hypertrophy compared with women from the general population, and preeclampsia was independently associated with left ventricular hypertrophy, regardless of the presence of cardiovascular risk factors, including chronic hypertension.REGISTRATION: URL: https://www.clinicalTrials.gov; Unique identifier: NCT03949829.",

keywords = "Adult, Cohort Studies, Female, Humans, Hypertension/epidemiology, Hypertrophy, Left Ventricular/epidemiology, Middle Aged, Pre-Eclampsia/epidemiology, Pregnancy, Prevalence, Risk Factors, Hypertension, Women, Hypertrophy, left ventricular, Preeclampsia, Cardiovascular diseases",

author = "Hauge, \{Maria G\} and Peter Damm and Kofoed, \{Klaus F\} and M{\o}ller, \{Emma Louise Ries\} and Lopez, \{Andrea G\} and Ersb{\o}ll, \{Anne S\} and Marianne Johansen and Sigvardsen, \{Per E\} and Pham, \{Michael H C\} and Goetze, \{Jens P\} and Andreas Fuchs and K{\"u}hl, \{J{\o}rgen T\} and Nordestgaard, \{B{\o}rge G\} and K{\o}ber, \{Lars V\} and Finn Gustafsson and Linde, \{Jesper J\}",

year = "2025",

month = may,

doi = "10.1161/HYPERTENSIONAHA.124.23497",

language = "English",

volume = "82",

pages = "774--783",

journal = "Hypertension",

issn = "0194-911X",

publisher = "Lippincott Williams and Wilkins Ltd.",

number = "5",

}

Hauge, MG, Damm, P, Kofoed, KF, Møller, ELR, Lopez, AG, Ersbøll, AS, Johansen, M, Sigvardsen, PE, Pham, MHC, Goetze, JP, Fuchs, A, Kühl, JT, Nordestgaard, BG, Køber, LV, Gustafsson, F & Linde, JJ 2025, 'Left Ventricular Hypertrophy in Women With a History of Preeclampsia', Hypertension, vol. 82, no. 5, pp. 774-783. https://doi.org/10.1161/HYPERTENSIONAHA.124.23497

TY - JOUR

T1 - Left Ventricular Hypertrophy in Women With a History of Preeclampsia

AU - Hauge, Maria G

AU - Damm, Peter

AU - Kofoed, Klaus F

AU - Møller, Emma Louise Ries

AU - Lopez, Andrea G

AU - Ersbøll, Anne S

AU - Johansen, Marianne

AU - Sigvardsen, Per E

AU - Pham, Michael H C

AU - Goetze, Jens P

AU - Fuchs, Andreas

AU - Kühl, Jørgen T

AU - Nordestgaard, Børge G

AU - Køber, Lars V

AU - Gustafsson, Finn

AU - Linde, Jesper J

PY - 2025/5

Y1 - 2025/5

N2 - BACKGROUND: As a hypertensive disorder of pregnancy, preeclampsia is associated with increased cardiovascular morbidity and mortality later in life. Since early signs of myocardial affection could indicate a higher risk of future cardiovascular disease manifestations, we investigated whether women with prior preeclampsia have a higher prevalence of left ventricular hypertrophy compared with women from the general population and to what extent chronic hypertension affects any potential difference.METHODS: In a cohort study, women aged 40 to 55 years with prior preeclampsia were compared with age- and parity-matched women from the general population. They underwent a research cardiac computed tomography, and the primary outcome was left ventricular hypertrophy, defined as a left ventricular mass index >30 g/m2.7.RESULTS: In 679 women with prior preeclampsia and 672 controls (median age, 47 years), we found a higher prevalence of left ventricular hypertrophy (14.0% versus 6.4%) in the preeclampsia group with an odds ratio of 1.62, 95% CI (1.07-2.46), P=0.024, median of 15 years (range, 0-28) after pregnancy, after adjustment for cardiovascular risk factors, including chronic hypertension. Left ventricular hypertrophy was more frequent among women with preeclampsia with (26.2% versus 15.6%) and without (5.5% versus 2.4%) chronic hypertension, and a mediation analysis showed that chronic hypertension explained 22% of the association between preeclampsia and left ventricular hypertrophy.CONCLUSIONS: Women with prior preeclampsia had a 2-fold higher prevalence of left ventricular hypertrophy compared with women from the general population, and preeclampsia was independently associated with left ventricular hypertrophy, regardless of the presence of cardiovascular risk factors, including chronic hypertension.REGISTRATION: URL: https://www.clinicalTrials.gov; Unique identifier: NCT03949829.

AB - BACKGROUND: As a hypertensive disorder of pregnancy, preeclampsia is associated with increased cardiovascular morbidity and mortality later in life. Since early signs of myocardial affection could indicate a higher risk of future cardiovascular disease manifestations, we investigated whether women with prior preeclampsia have a higher prevalence of left ventricular hypertrophy compared with women from the general population and to what extent chronic hypertension affects any potential difference.METHODS: In a cohort study, women aged 40 to 55 years with prior preeclampsia were compared with age- and parity-matched women from the general population. They underwent a research cardiac computed tomography, and the primary outcome was left ventricular hypertrophy, defined as a left ventricular mass index >30 g/m2.7.RESULTS: In 679 women with prior preeclampsia and 672 controls (median age, 47 years), we found a higher prevalence of left ventricular hypertrophy (14.0% versus 6.4%) in the preeclampsia group with an odds ratio of 1.62, 95% CI (1.07-2.46), P=0.024, median of 15 years (range, 0-28) after pregnancy, after adjustment for cardiovascular risk factors, including chronic hypertension. Left ventricular hypertrophy was more frequent among women with preeclampsia with (26.2% versus 15.6%) and without (5.5% versus 2.4%) chronic hypertension, and a mediation analysis showed that chronic hypertension explained 22% of the association between preeclampsia and left ventricular hypertrophy.CONCLUSIONS: Women with prior preeclampsia had a 2-fold higher prevalence of left ventricular hypertrophy compared with women from the general population, and preeclampsia was independently associated with left ventricular hypertrophy, regardless of the presence of cardiovascular risk factors, including chronic hypertension.REGISTRATION: URL: https://www.clinicalTrials.gov; Unique identifier: NCT03949829.

KW - Adult

KW - Cohort Studies

KW - Female

KW - Humans

KW - Hypertension/epidemiology

KW - Hypertrophy, Left Ventricular/epidemiology

KW - Middle Aged

KW - Pre-Eclampsia/epidemiology

KW - Pregnancy

KW - Prevalence

KW - Risk Factors

KW - Hypertension

KW - Women

KW - Hypertrophy, left ventricular

KW - Preeclampsia

KW - Cardiovascular diseases

U2 - 10.1161/HYPERTENSIONAHA.124.23497

DO - 10.1161/HYPERTENSIONAHA.124.23497

M3 - Article

C2 - 39540300

SN - 0194-911X

VL - 82

SP - 774

EP - 783

JO - Hypertension

JF - Hypertension

IS - 5

ER -

Left Ventricular Hypertrophy in Women With a History of Preeclampsia

Abstract

Funding

Keywords

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