High-Dose Influenza Vaccination in Atherosclerotic Cardiovascular Disease: A Multinational Pooled Analysis of DANFLU-2 and GALFLU (FLUNITY-HD)

Manan Pareek; Niklas Dyrby Johansen; Daniel Modin; Jacobo Pardo-Seco; Carmen Rodriguez-Tenreiro-Sánchez; Matthew M Loiacono; Rebecca C Harris; Marine Dufournet; Robertus van Aalst; Ayman Chit; Carsten Schade Larsen; Lykke Larsen; Lothar Wiese; Michael Dalager-Pedersen; Brian L Claggett; Kira Hyldekær Janstrup; Carmen Duran-Parrondo; Marta Piñeiro-Sotelo; Martín Cribeiro-González; Mónica Conde-Pájaro; Susana Mirás-Carballal; Juan-Manuel González-Pérez; Scott D Solomon; Pradeesh Sivapalan; Cyril Jean-Marie Martel; Jens Ulrik Stæhr Jensen; Federico Martinón-Torres; Tor Biering-Sørensen; DANFLU-2 Study Group and GALFLU Trial Team

doi:10.1016/j.jacc.2025.12.080

High-Dose Influenza Vaccination in Atherosclerotic Cardiovascular Disease: A Multinational Pooled Analysis of DANFLU-2 and GALFLU (FLUNITY-HD)

Manan Pareek
, Niklas Dyrby Johansen
, Daniel Modin
, Jacobo Pardo-Seco
, Carmen Rodriguez-Tenreiro-Sánchez
, Matthew M Loiacono
, Rebecca C Harris
, Marine Dufournet
, Robertus van Aalst
, Ayman Chit
, Carsten Schade Larsen
, Lykke Larsen
, Lothar Wiese
, Michael Dalager-Pedersen
, Brian L Claggett
, Kira Hyldekær Janstrup
, Carmen Duran-Parrondo
, Marta Piñeiro-Sotelo
, Martín Cribeiro-González
, Mónica Conde-Pájaro

Susana Mirás-Carballal, Juan-Manuel González-Pérez, Scott D Solomon, Pradeesh Sivapalan, Cyril Jean-Marie Martel, Jens Ulrik Stæhr Jensen, Federico Martinón-Torres, Tor Biering-Sørensen, DANFLU-2 Study Group and GALFLU Trial Team

Medicine (Roskilde)

Research output: Contribution to journal › Letter › Research › peer-review

Original language	English
Pages (from-to)	1374-1380
Number of pages	7
Journal	Journal of the American College of Cardiology
Volume	87
Issue number	11
Early online date	9 Feb 2026
DOIs	https://doi.org/10.1016/j.jacc.2025.12.080
Publication status	Published - 24 Mar 2026

Keywords

Atherosclerosis
Cardiovascular diseases
Influenza
Meta-analysis
Randomized controlled trial
Registries
Vaccination

Access to Document

10.1016/j.jacc.2025.12.080

Cite this

Pareek, M., Johansen, N. D., Modin, D., Pardo-Seco, J., Rodriguez-Tenreiro-Sánchez, C., Loiacono, M. M., Harris, R. C., Dufournet, M., van Aalst, R., Chit, A., Larsen, C. S., Larsen, L., Wiese, L., Dalager-Pedersen, M., Claggett, B. L., Janstrup, K. H., Duran-Parrondo, C., Piñeiro-Sotelo, M., Cribeiro-González, M., ... DANFLU-2 Study Group and GALFLU Trial Team (2026). High-Dose Influenza Vaccination in Atherosclerotic Cardiovascular Disease: A Multinational Pooled Analysis of DANFLU-2 and GALFLU (FLUNITY-HD). Journal of the American College of Cardiology, 87(11), 1374-1380. https://doi.org/10.1016/j.jacc.2025.12.080

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title = "High-Dose Influenza Vaccination in Atherosclerotic Cardiovascular Disease: A Multinational Pooled Analysis of DANFLU-2 and GALFLU (FLUNITY-HD)",

keywords = "Atherosclerosis, Cardiovascular diseases, Influenza, Meta-analysis, Randomized controlled trial, Registries, Vaccination",

author = "Manan Pareek and Johansen, \{Niklas Dyrby\} and Daniel Modin and Jacobo Pardo-Seco and Carmen Rodriguez-Tenreiro-S{\'a}nchez and Loiacono, \{Matthew M\} and Harris, \{Rebecca C\} and Marine Dufournet and \{van Aalst\}, Robertus and Ayman Chit and Larsen, \{Carsten Schade\} and Lykke Larsen and Lothar Wiese and Michael Dalager-Pedersen and Claggett, \{Brian L\} and Janstrup, \{Kira Hyldek{\ae}r\} and Carmen Duran-Parrondo and Marta Pi{\~n}eiro-Sotelo and Mart{\'i}n Cribeiro-Gonz{\'a}lez and M{\'o}nica Conde-P{\'a}jaro and Susana Mir{\'a}s-Carballal and Juan-Manuel Gonz{\'a}lez-P{\'e}rez and Solomon, \{Scott D\} and Pradeesh Sivapalan and Martel, \{Cyril Jean-Marie\} and Jensen, \{Jens Ulrik St{\ae}hr\} and Federico Martin{\'o}n-Torres and Tor Biering-S{\o}rensen and \{DANFLU-2 Study Group and GALFLU Trial Team\}",

year = "2026",

month = mar,

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doi = "10.1016/j.jacc.2025.12.080",

language = "English",

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pages = "1374--1380",

journal = "Journal of the American College of Cardiology",

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Pareek, M, Johansen, ND, Modin, D, Pardo-Seco, J, Rodriguez-Tenreiro-Sánchez, C, Loiacono, MM, Harris, RC, Dufournet, M, van Aalst, R, Chit, A, Larsen, CS, Larsen, L, Wiese, L, Dalager-Pedersen, M, Claggett, BL, Janstrup, KH, Duran-Parrondo, C, Piñeiro-Sotelo, M, Cribeiro-González, M, Conde-Pájaro, M, Mirás-Carballal, S, González-Pérez, J-M, Solomon, SD, Sivapalan, P, Martel, CJ-M, Jensen, JUS, Martinón-Torres, F, Biering-Sørensen, T & DANFLU-2 Study Group and GALFLU Trial Team 2026, 'High-Dose Influenza Vaccination in Atherosclerotic Cardiovascular Disease: A Multinational Pooled Analysis of DANFLU-2 and GALFLU (FLUNITY-HD)', Journal of the American College of Cardiology, vol. 87, no. 11, pp. 1374-1380. https://doi.org/10.1016/j.jacc.2025.12.080

High-Dose Influenza Vaccination in Atherosclerotic Cardiovascular Disease: A Multinational Pooled Analysis of DANFLU-2 and GALFLU (FLUNITY-HD). / Pareek, Manan; Johansen, Niklas Dyrby; Modin, Daniel et al.
In: Journal of the American College of Cardiology, Vol. 87, No. 11, 24.03.2026, p. 1374-1380.

Research output: Contribution to journal › Letter › Research › peer-review

TY - JOUR

T1 - High-Dose Influenza Vaccination in Atherosclerotic Cardiovascular Disease

T2 - A Multinational Pooled Analysis of DANFLU-2 and GALFLU (FLUNITY-HD)

AU - Pareek, Manan

AU - Johansen, Niklas Dyrby

AU - Modin, Daniel

AU - Pardo-Seco, Jacobo

AU - Rodriguez-Tenreiro-Sánchez, Carmen

AU - Loiacono, Matthew M

AU - Harris, Rebecca C

AU - Dufournet, Marine

AU - van Aalst, Robertus

AU - Chit, Ayman

AU - Larsen, Carsten Schade

AU - Larsen, Lykke

AU - Wiese, Lothar

AU - Dalager-Pedersen, Michael

AU - Claggett, Brian L

AU - Janstrup, Kira Hyldekær

AU - Duran-Parrondo, Carmen

AU - Piñeiro-Sotelo, Marta

AU - Cribeiro-González, Martín

AU - Conde-Pájaro, Mónica

AU - Mirás-Carballal, Susana

AU - González-Pérez, Juan-Manuel

AU - Solomon, Scott D

AU - Sivapalan, Pradeesh

AU - Martel, Cyril Jean-Marie

AU - Jensen, Jens Ulrik Stæhr

AU - Martinón-Torres, Federico

AU - Biering-Sørensen, Tor

AU - DANFLU-2 Study Group and GALFLU Trial Team

PY - 2026/3/24

Y1 - 2026/3/24

KW - Atherosclerosis

KW - Cardiovascular diseases

KW - Influenza

KW - Meta-analysis

KW - Randomized controlled trial

KW - Registries

KW - Vaccination

U2 - 10.1016/j.jacc.2025.12.080

DO - 10.1016/j.jacc.2025.12.080

M3 - Letter

C2 - 41706066

SN - 0735-1097

VL - 87

SP - 1374

EP - 1380

JO - Journal of the American College of Cardiology

JF - Journal of the American College of Cardiology

IS - 11

ER -