Hepcidin levels are low during pregnancy and increase around delivery in women without iron deficiency - A prospective cohort study

Katrine K. Hedengran; Dick Nelson; Malene R. Andersen; Steen Stender; Pal B. Szecsi

doi:10.3109/14767058.2015.1052396

Hepcidin levels are low during pregnancy and increase around delivery in women without iron deficiency - A prospective cohort study

Katrine K. Hedengran
, Dick Nelson
, Malene R. Andersen
, Steen Stender
, Pal B. Szecsi^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

Abstract

Objective: To investigate hepcidin during pregnancy, delivery and postpartum in women with sufficient iron supplementation.Methods: Hepcidin was measured using LC-MS spectroscopy in 37 women during pregnancy, delivery and postpartum period in this longitudinal study.Results: Hepcidin was low during pregnancy and increased at delivery and postpartum. No correlations with inflammatory markers or iron metabolism were observed during pregnancy; at delivery a correlation with inflammatory markers was observed.Conclusion: During pregnancy, in women with sufficient iron supplementation, hepcidin is low and does not reflect iron status. During delivery and the postpartum period, hepcidin functions as a marker of inflammation.

Original language	English
Pages (from-to)	1506-1508
Number of pages	3
Journal	Journal of Maternal-Fetal and Neonatal Medicine
Volume	29
Issue number	9
DOIs	https://doi.org/10.3109/14767058.2015.1052396
Publication status	Published - 2 May 2016

Keywords

Anemia
delivery
hepcidin 25
iron deficiency
pregnancy

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10.3109/14767058.2015.1052396

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@article{6ee21f08e73b4582b7fa77edffc6c09b,

title = "Hepcidin levels are low during pregnancy and increase around delivery in women without iron deficiency - A prospective cohort study",

abstract = "Objective: To investigate hepcidin during pregnancy, delivery and postpartum in women with sufficient iron supplementation.Methods: Hepcidin was measured using LC-MS spectroscopy in 37 women during pregnancy, delivery and postpartum period in this longitudinal study.Results: Hepcidin was low during pregnancy and increased at delivery and postpartum. No correlations with inflammatory markers or iron metabolism were observed during pregnancy; at delivery a correlation with inflammatory markers was observed.Conclusion: During pregnancy, in women with sufficient iron supplementation, hepcidin is low and does not reflect iron status. During delivery and the postpartum period, hepcidin functions as a marker of inflammation.",

keywords = "Anemia, delivery, hepcidin 25, iron deficiency, pregnancy",

author = "Hedengran, \{Katrine K.\} and Dick Nelson and Andersen, \{Malene R.\} and Steen Stender and Szecsi, \{Pal B.\}",

year = "2016",

month = may,

day = "2",

doi = "10.3109/14767058.2015.1052396",

language = "English",

volume = "29",

pages = "1506--1508",

journal = "Journal of Maternal-Fetal and Neonatal Medicine",

issn = "1476-7058",

publisher = "Taylor and Francis Ltd.",

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Hepcidin levels are low during pregnancy and increase around delivery in women without iron deficiency - A prospective cohort study. / Hedengran, Katrine K.; Nelson, Dick; Andersen, Malene R. et al.
In: Journal of Maternal-Fetal and Neonatal Medicine, Vol. 29, No. 9, 02.05.2016, p. 1506-1508.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - Hepcidin levels are low during pregnancy and increase around delivery in women without iron deficiency - A prospective cohort study

AU - Hedengran, Katrine K.

AU - Nelson, Dick

AU - Andersen, Malene R.

AU - Stender, Steen

AU - Szecsi, Pal B.

PY - 2016/5/2

Y1 - 2016/5/2

N2 - Objective: To investigate hepcidin during pregnancy, delivery and postpartum in women with sufficient iron supplementation.Methods: Hepcidin was measured using LC-MS spectroscopy in 37 women during pregnancy, delivery and postpartum period in this longitudinal study.Results: Hepcidin was low during pregnancy and increased at delivery and postpartum. No correlations with inflammatory markers or iron metabolism were observed during pregnancy; at delivery a correlation with inflammatory markers was observed.Conclusion: During pregnancy, in women with sufficient iron supplementation, hepcidin is low and does not reflect iron status. During delivery and the postpartum period, hepcidin functions as a marker of inflammation.

AB - Objective: To investigate hepcidin during pregnancy, delivery and postpartum in women with sufficient iron supplementation.Methods: Hepcidin was measured using LC-MS spectroscopy in 37 women during pregnancy, delivery and postpartum period in this longitudinal study.Results: Hepcidin was low during pregnancy and increased at delivery and postpartum. No correlations with inflammatory markers or iron metabolism were observed during pregnancy; at delivery a correlation with inflammatory markers was observed.Conclusion: During pregnancy, in women with sufficient iron supplementation, hepcidin is low and does not reflect iron status. During delivery and the postpartum period, hepcidin functions as a marker of inflammation.

KW - Anemia

KW - delivery

KW - hepcidin 25

KW - iron deficiency

KW - pregnancy

UR - https://www.scopus.com/pages/publications/84958114309

U2 - 10.3109/14767058.2015.1052396

DO - 10.3109/14767058.2015.1052396

M3 - Article

C2 - 26212583

AN - SCOPUS:84958114309

SN - 1476-7058

VL - 29

SP - 1506

EP - 1508

JO - Journal of Maternal-Fetal and Neonatal Medicine

JF - Journal of Maternal-Fetal and Neonatal Medicine

IS - 9

ER -

Hepcidin levels are low during pregnancy and increase around delivery in women without iron deficiency - A prospective cohort study

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Keywords

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