TY - JOUR
T1 - Hemodynamic Changes in Response to GLP-1 Treatment in ICD and CRT Patients
T2 - Insights From HeartLogic Sensor Data
AU - Fussing, Frederik Holme
AU - Davodian, Lise Witten
AU - Davodian, Danny Witten
AU - Johansen, Niklas Dyrby
AU - Kumarathurai, Preman
AU - Modin, Daniel
AU - Sattler, Stefan
AU - Larroudé, Charlotte
AU - Risum, Niels
AU - Vinther, Michael
AU - Køber, Lars
AU - Rossing, Kasper
AU - Ersbøll, Mads
AU - Poulsen, Mikael Kjær
AU - Løgstrup, Brian Bridal
AU - Holm, Katja Fiedler
AU - Haugan, Ketil J
AU - Chien, Christopher
AU - Claggett, Brian
AU - Solomon, Scott
AU - Fudim, Marat
AU - Hernandez, Adrian
AU - Bekfani, Tarek
AU - Johansen, Jens Brock
AU - Nielsen, Jens Cosedis
AU - Stolen, Craig M
AU - Biering-Sørensen, Tor
N1 - © The Author(s) 2026. Published by Oxford University Press on behalf of the European Society of Cardiology.
PY - 2026/4/16
Y1 - 2026/4/16
N2 - BACKGROUND: Glucagon-like peptide-1 receptor agonist (GLP-1RA) therapy is increasingly used, but the physiological effects in patients with heart failure and reduced ejection fraction (HFrEF) remain uncertain. Continuously collected data from implantable cardiac devices may enable evaluation of drug effects in a real-world setting.METHODS: In a nationwide Danish retrospective matched cohort study, GLP-1RA initiators with implantable cardiac devices were matched 1:5 to unexposed device recipients by sex and age. Sensor data were assessed from 30 days before to 30 days after initiation. Primary outcomes were changes in heart rate and thoracic impedance. Analyses were adjusted for baseline sensor value, BMI category, hypertension, and type 2 diabetes. Prespecified subgroup analyses were performed in patients with HFrEF.RESULTS: In 666 patients (111 GLP-1RA initiators, 555 matched controls), semaglutide was used in 95% of initiators. Compared with controls, GLP-1RA initiation was associated with higher night heart rate (adjusted difference 2.12 bpm; 95% CI, 1.38 to 2.87), higher daily heart rate (1.46 bpm; 95% CI, 0.65 to 2.06), and higher thoracic impedance (0.66 Ω; 95% CI, 0.17 to 1.15) (all P<0.01). S1 amplitude decreased (-0.09 mG; 95% CI, -0.14 to -0.04; P<0.01). Heart rate increases followed a stepwise pattern across semaglutide dose levels, with an average increase of 2.5 bpm per dose escalation. Findings were directionally consistent in patients with HFrEF (GLP-1RA n=80), with no evidence of effect modification.CONCLUSION: GLP-1RA initiation was associated with measurable changes in device-derived physiology. Larger studies are needed to evaluate clinical implications, including in HFrEF.TRIAL REGISTRATION: Clinicaltrials.gov (NCT06099158).
AB - BACKGROUND: Glucagon-like peptide-1 receptor agonist (GLP-1RA) therapy is increasingly used, but the physiological effects in patients with heart failure and reduced ejection fraction (HFrEF) remain uncertain. Continuously collected data from implantable cardiac devices may enable evaluation of drug effects in a real-world setting.METHODS: In a nationwide Danish retrospective matched cohort study, GLP-1RA initiators with implantable cardiac devices were matched 1:5 to unexposed device recipients by sex and age. Sensor data were assessed from 30 days before to 30 days after initiation. Primary outcomes were changes in heart rate and thoracic impedance. Analyses were adjusted for baseline sensor value, BMI category, hypertension, and type 2 diabetes. Prespecified subgroup analyses were performed in patients with HFrEF.RESULTS: In 666 patients (111 GLP-1RA initiators, 555 matched controls), semaglutide was used in 95% of initiators. Compared with controls, GLP-1RA initiation was associated with higher night heart rate (adjusted difference 2.12 bpm; 95% CI, 1.38 to 2.87), higher daily heart rate (1.46 bpm; 95% CI, 0.65 to 2.06), and higher thoracic impedance (0.66 Ω; 95% CI, 0.17 to 1.15) (all P<0.01). S1 amplitude decreased (-0.09 mG; 95% CI, -0.14 to -0.04; P<0.01). Heart rate increases followed a stepwise pattern across semaglutide dose levels, with an average increase of 2.5 bpm per dose escalation. Findings were directionally consistent in patients with HFrEF (GLP-1RA n=80), with no evidence of effect modification.CONCLUSION: GLP-1RA initiation was associated with measurable changes in device-derived physiology. Larger studies are needed to evaluate clinical implications, including in HFrEF.TRIAL REGISTRATION: Clinicaltrials.gov (NCT06099158).
U2 - 10.1093/ejhf/xuag114
DO - 10.1093/ejhf/xuag114
M3 - Article
C2 - 41990363
SN - 1388-9842
JO - European Journal of Heart Failure
JF - European Journal of Heart Failure
ER -