Exploring The Association Between Severe Respiratory Syncytial Virus Infection and Asthma: a Registry-Based Twin Study

Simon Francis Thomsen; Sophie V D Sluis; Lone G Stensballe; Danielle Posthuma; Axel Skytthe; Kirsten O Kyvik; David L Duffy; Vibeke Backer; Hans Bisgaard

doi:10.1164/rccm.200809-1471OC

Exploring The Association Between Severe Respiratory Syncytial Virus Infection and Asthma: a Registry-Based Twin Study

Simon Francis Thomsen
, Sophie V D Sluis
, Lone G Stensballe
, Danielle Posthuma
, Axel Skytthe
, Kirsten O Kyvik
, David L Duffy
, Vibeke Backer
, Hans Bisgaard

Research output: Contribution to journal › Article › Research › peer-review

Abstract

BACKGROUND: We explored the nature of the association between severe respiratory syncytial virus (RSV) infection and asthma in a population-based sample of twins. METHODS: Data on hospitalization due to RSV infection was gathered for all twins born in Denmark between 1994 and 2000 (8,280 pairs) and linked to information on asthma obtained from hospital discharge registries and parent-completed questionnaires. Genetic variance components models and direction of causation models were fitted to the observed data. RESULTS: RSV hospitalization and asthma were positively associated (r=0.43) and genetic determinants for the two disorders overlapped completely. Modeling the direction of causation between RSV hospitalization and asthma showed that a model, in which asthma âcausesâ RSV hospitalization fitted the data significantly better (p=0.39 for deterioration in model fit), than a model, in which RSV hospitalization âcausesâ asthma (p

Original language	English
Pages (from-to)	1091-7
Number of pages	7
Journal	American Journal of Respiratory and Critical Care Medicine
Volume	179
Issue number	12
DOIs	https://doi.org/10.1164/rccm.200809-1471OC
Publication status	Published - 12 Mar 2009

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10.1164/rccm.200809-1471OC

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Thomsen, S. F., Sluis, S. V. D., Stensballe, L. G., Posthuma, D., Skytthe, A., Kyvik, K. O., Duffy, D. L., Backer, V., & Bisgaard, H. (2009). Exploring The Association Between Severe Respiratory Syncytial Virus Infection and Asthma: a Registry-Based Twin Study. American Journal of Respiratory and Critical Care Medicine, 179(12), 1091-7. https://doi.org/10.1164/rccm.200809-1471OC

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title = "Exploring The Association Between Severe Respiratory Syncytial Virus Infection and Asthma: a Registry-Based Twin Study",

abstract = "BACKGROUND: We explored the nature of the association between severe respiratory syncytial virus (RSV) infection and asthma in a population-based sample of twins. METHODS: Data on hospitalization due to RSV infection was gathered for all twins born in Denmark between 1994 and 2000 (8,280 pairs) and linked to information on asthma obtained from hospital discharge registries and parent-completed questionnaires. Genetic variance components models and direction of causation models were fitted to the observed data. RESULTS: RSV hospitalization and asthma were positively associated (r=0.43) and genetic determinants for the two disorders overlapped completely. Modeling the direction of causation between RSV hospitalization and asthma showed that a model, in which asthma {\^a}causes{\^a} RSV hospitalization fitted the data significantly better (p=0.39 for deterioration in model fit), than a model, in which RSV hospitalization {\^a}causes{\^a} asthma (p",

author = "Thomsen, \{Simon Francis\} and Sluis, \{Sophie V D\} and Stensballe, \{Lone G\} and Danielle Posthuma and Axel Skytthe and Kyvik, \{Kirsten O\} and Duffy, \{David L\} and Vibeke Backer and Hans Bisgaard",

year = "2009",

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doi = "10.1164/rccm.200809-1471OC",

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Thomsen, SF, Sluis, SVD, Stensballe, LG, Posthuma, D, Skytthe, A, Kyvik, KO, Duffy, DL, Backer, V & Bisgaard, H 2009, 'Exploring The Association Between Severe Respiratory Syncytial Virus Infection and Asthma: a Registry-Based Twin Study', American Journal of Respiratory and Critical Care Medicine, vol. 179, no. 12, pp. 1091-7. https://doi.org/10.1164/rccm.200809-1471OC

Exploring The Association Between Severe Respiratory Syncytial Virus Infection and Asthma: a Registry-Based Twin Study. / Thomsen, Simon Francis; Sluis, Sophie V D; Stensballe, Lone G et al.
In: American Journal of Respiratory and Critical Care Medicine, Vol. 179, No. 12, 12.03.2009, p. 1091-7.

Research output: Contribution to journal › Article › Research › peer-review

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AU - Thomsen, Simon Francis

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AU - Posthuma, Danielle

AU - Skytthe, Axel

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AU - Duffy, David L

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AU - Bisgaard, Hans

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AB - BACKGROUND: We explored the nature of the association between severe respiratory syncytial virus (RSV) infection and asthma in a population-based sample of twins. METHODS: Data on hospitalization due to RSV infection was gathered for all twins born in Denmark between 1994 and 2000 (8,280 pairs) and linked to information on asthma obtained from hospital discharge registries and parent-completed questionnaires. Genetic variance components models and direction of causation models were fitted to the observed data. RESULTS: RSV hospitalization and asthma were positively associated (r=0.43) and genetic determinants for the two disorders overlapped completely. Modeling the direction of causation between RSV hospitalization and asthma showed that a model, in which asthma âcausesâ RSV hospitalization fitted the data significantly better (p=0.39 for deterioration in model fit), than a model, in which RSV hospitalization âcausesâ asthma (p

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