Demonstration of pepsinogen C in human pancreatic islets

P. B. Szecsi; H. Halgreen; S. S. Poulsen; C. K. Axelsson; M. Damkjær-Nielsen; T. Kjær; B. Foltmann

doi:10.1136/gut.28.10.1208

Demonstration of pepsinogen C in human pancreatic islets

P. B. Szecsi^*
, H. Halgreen
, S. S. Poulsen
, C. K. Axelsson
, M. Damkjær-Nielsen
, T. Kjær
, B. Foltmann

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

Abstract

Pancreatic tissue from 16 post mortem kidney donors have been examined for the content of pepsinogens. A zymogen with electrophoretic mobility, isoelectric point and molecular weight equal to that of pepsinogen C of gastric origin was found in all specimens. A comparison between pepsinogen C extracted from pancreatic tissue and gastric mucosa demonstrated immunological identity. Quantitative measurements with a radioimmunoassay showed pepsinogen C concentrations in pancreatic tissue three to 80 times higher than those of blood serum. Immunohistochemical staining gave positive reaction for pepsinogen C only in the alpha cells of the pancreatic islets.

Original language	English
Pages (from-to)	1208-1214
Number of pages	7
Journal	Gut
Volume	28
Issue number	10
DOIs	https://doi.org/10.1136/gut.28.10.1208
Publication status	Published - 1 Jan 1987

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title = "Demonstration of pepsinogen C in human pancreatic islets",

abstract = "Pancreatic tissue from 16 post mortem kidney donors have been examined for the content of pepsinogens. A zymogen with electrophoretic mobility, isoelectric point and molecular weight equal to that of pepsinogen C of gastric origin was found in all specimens. A comparison between pepsinogen C extracted from pancreatic tissue and gastric mucosa demonstrated immunological identity. Quantitative measurements with a radioimmunoassay showed pepsinogen C concentrations in pancreatic tissue three to 80 times higher than those of blood serum. Immunohistochemical staining gave positive reaction for pepsinogen C only in the alpha cells of the pancreatic islets.",

author = "Szecsi, \{P. B.\} and H. Halgreen and Poulsen, \{S. S.\} and Axelsson, \{C. K.\} and M. Damkj{\ae}r-Nielsen and T. Kj{\ae}r and B. Foltmann",

year = "1987",

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doi = "10.1136/gut.28.10.1208",

language = "English",

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T1 - Demonstration of pepsinogen C in human pancreatic islets

AU - Szecsi, P. B.

AU - Halgreen, H.

AU - Poulsen, S. S.

AU - Axelsson, C. K.

AU - Damkjær-Nielsen, M.

AU - Kjær, T.

AU - Foltmann, B.

PY - 1987/1/1

Y1 - 1987/1/1

N2 - Pancreatic tissue from 16 post mortem kidney donors have been examined for the content of pepsinogens. A zymogen with electrophoretic mobility, isoelectric point and molecular weight equal to that of pepsinogen C of gastric origin was found in all specimens. A comparison between pepsinogen C extracted from pancreatic tissue and gastric mucosa demonstrated immunological identity. Quantitative measurements with a radioimmunoassay showed pepsinogen C concentrations in pancreatic tissue three to 80 times higher than those of blood serum. Immunohistochemical staining gave positive reaction for pepsinogen C only in the alpha cells of the pancreatic islets.

AB - Pancreatic tissue from 16 post mortem kidney donors have been examined for the content of pepsinogens. A zymogen with electrophoretic mobility, isoelectric point and molecular weight equal to that of pepsinogen C of gastric origin was found in all specimens. A comparison between pepsinogen C extracted from pancreatic tissue and gastric mucosa demonstrated immunological identity. Quantitative measurements with a radioimmunoassay showed pepsinogen C concentrations in pancreatic tissue three to 80 times higher than those of blood serum. Immunohistochemical staining gave positive reaction for pepsinogen C only in the alpha cells of the pancreatic islets.

UR - https://www.scopus.com/pages/publications/0023232157

U2 - 10.1136/gut.28.10.1208

DO - 10.1136/gut.28.10.1208

M3 - Article

C2 - 3315877

AN - SCOPUS:0023232157

SN - 0017-5749

VL - 28

SP - 1208

EP - 1214

JO - Gut

JF - Gut

IS - 10

ER -

Demonstration of pepsinogen C in human pancreatic islets

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