Comparison of Three Survival Scores in a Series of Patients ≥80 Years of Age Irradiated for Bone Metastases

Dirk Rades; Cansu Delikanli; Steven E Schild; Charlotte Kristiansen; Soren Tvilsted; Stefan Janssen

doi:10.21873/anticanres.16221

Comparison of Three Survival Scores in a Series of Patients ≥80 Years of Age Irradiated for Bone Metastases

Dirk Rades^*
, Cansu Delikanli
, Steven E Schild
, Charlotte Kristiansen
, Soren Tvilsted
, Stefan Janssen

^*Corresponding author for this work

Management (SUH)

Research output: Contribution to journal › Article › Research › peer-review

Abstract

BACKGROUND/AIM: Very elderly patients irradiated for bone metastases likely benefit from individualized treatments. A specific survival score was created for this group and compared to existing instruments.

PATIENTS AND METHODS: Ninety-six patients aged 80+ irradiated for bone metastases were retrospectively evaluated. Dose-fractionation regimen plus twelve characteristics were evaluated for survival.

RESULTS: In the Cox regression model, performance status and tumor type were significant and used for the score, which included three groups (5-7, 8-12, and 14 points) with 6-month survival rates of 15%, 52%, and 90%. Positive predictive values (PPVs) regarding death ≤6 months were 85% (new score), 100% (previous 65+ score), and 84% (previous score for any age). The new instrument and the 65+ score were also very accurate regarding survival. Since PPV regarding death was calculated from only four patients for the 65+ score, this PPV may be less conclusive than that for the new instrument.

CONCLUSION: The new score appears useful for patients aged 80+ irradiated for bone metastases.

Original language	English
Pages (from-to)	801-807
Number of pages	7
Journal	Anticancer Research
Volume	43
Issue number	2
DOIs	https://doi.org/10.21873/anticanres.16221
Publication status	Published - Feb 2023

Keywords

Aged
Humans
Aged, 80 and over
Retrospective Studies
Prognosis
Bone Neoplasms/radiotherapy
Proportional Hazards Models
Cranial Irradiation
Survival Rate
Brain Neoplasms/secondary

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@article{46bf907fc9e342c88c45d66c7a50407d,

title = "Comparison of Three Survival Scores in a Series of Patients ≥80 Years of Age Irradiated for Bone Metastases",

abstract = "BACKGROUND/AIM: Very elderly patients irradiated for bone metastases likely benefit from individualized treatments. A specific survival score was created for this group and compared to existing instruments.PATIENTS AND METHODS: Ninety-six patients aged 80+ irradiated for bone metastases were retrospectively evaluated. Dose-fractionation regimen plus twelve characteristics were evaluated for survival.RESULTS: In the Cox regression model, performance status and tumor type were significant and used for the score, which included three groups (5-7, 8-12, and 14 points) with 6-month survival rates of 15\%, 52\%, and 90\%. Positive predictive values (PPVs) regarding death ≤6 months were 85\% (new score), 100\% (previous 65+ score), and 84\% (previous score for any age). The new instrument and the 65+ score were also very accurate regarding survival. Since PPV regarding death was calculated from only four patients for the 65+ score, this PPV may be less conclusive than that for the new instrument.CONCLUSION: The new score appears useful for patients aged 80+ irradiated for bone metastases.",

keywords = "Aged, Humans, Aged, 80 and over, Retrospective Studies, Prognosis, Bone Neoplasms/radiotherapy, Proportional Hazards Models, Cranial Irradiation, Survival Rate, Brain Neoplasms/secondary",

author = "Dirk Rades and Cansu Delikanli and Schild, \{Steven E\} and Charlotte Kristiansen and Soren Tvilsted and Stefan Janssen",

year = "2023",

month = feb,

doi = "10.21873/anticanres.16221",

language = "English",

volume = "43",

pages = "801--807",

journal = "Anticancer Research",

issn = "0250-7005",

publisher = "International Institute of Anticancer Research",

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T1 - Comparison of Three Survival Scores in a Series of Patients ≥80 Years of Age Irradiated for Bone Metastases

AU - Rades, Dirk

AU - Delikanli, Cansu

AU - Schild, Steven E

AU - Kristiansen, Charlotte

AU - Tvilsted, Soren

AU - Janssen, Stefan

PY - 2023/2

Y1 - 2023/2

N2 - BACKGROUND/AIM: Very elderly patients irradiated for bone metastases likely benefit from individualized treatments. A specific survival score was created for this group and compared to existing instruments.PATIENTS AND METHODS: Ninety-six patients aged 80+ irradiated for bone metastases were retrospectively evaluated. Dose-fractionation regimen plus twelve characteristics were evaluated for survival.RESULTS: In the Cox regression model, performance status and tumor type were significant and used for the score, which included three groups (5-7, 8-12, and 14 points) with 6-month survival rates of 15%, 52%, and 90%. Positive predictive values (PPVs) regarding death ≤6 months were 85% (new score), 100% (previous 65+ score), and 84% (previous score for any age). The new instrument and the 65+ score were also very accurate regarding survival. Since PPV regarding death was calculated from only four patients for the 65+ score, this PPV may be less conclusive than that for the new instrument.CONCLUSION: The new score appears useful for patients aged 80+ irradiated for bone metastases.

AB - BACKGROUND/AIM: Very elderly patients irradiated for bone metastases likely benefit from individualized treatments. A specific survival score was created for this group and compared to existing instruments.PATIENTS AND METHODS: Ninety-six patients aged 80+ irradiated for bone metastases were retrospectively evaluated. Dose-fractionation regimen plus twelve characteristics were evaluated for survival.RESULTS: In the Cox regression model, performance status and tumor type were significant and used for the score, which included three groups (5-7, 8-12, and 14 points) with 6-month survival rates of 15%, 52%, and 90%. Positive predictive values (PPVs) regarding death ≤6 months were 85% (new score), 100% (previous 65+ score), and 84% (previous score for any age). The new instrument and the 65+ score were also very accurate regarding survival. Since PPV regarding death was calculated from only four patients for the 65+ score, this PPV may be less conclusive than that for the new instrument.CONCLUSION: The new score appears useful for patients aged 80+ irradiated for bone metastases.

KW - Aged

KW - Humans

KW - Aged, 80 and over

KW - Retrospective Studies

KW - Prognosis

KW - Bone Neoplasms/radiotherapy

KW - Proportional Hazards Models

KW - Cranial Irradiation

KW - Survival Rate

KW - Brain Neoplasms/secondary

U2 - 10.21873/anticanres.16221

DO - 10.21873/anticanres.16221

M3 - Article

C2 - 36697108

SN - 0250-7005

VL - 43

SP - 801

EP - 807

JO - Anticancer Research

JF - Anticancer Research

IS - 2

ER -

Comparison of Three Survival Scores in a Series of Patients ≥80 Years of Age Irradiated for Bone Metastases

Abstract

Keywords

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