Comorbidity of migraine with ADHD in adults 11 Medical and Health Sciences 1117 Public Health and Health Services 17 Psychology and Cognitive Sciences 1701 Psychology

Thomas Folkmann Hansen; Louise K. Hoeffding; Lisette Kogelman; Thilde Marie Haspang; Henrik Ullum; Erik Sørensen; Christian Erikstrup; Ole Birger Pedersen; Kaspar René Nielsen; Henrik Hjalgrim; Helene M. Paarup; Thomas Werge; Kristoffer Burgdorf

doi:10.1186/s12883-018-1149-6

Comorbidity of migraine with ADHD in adults 11 Medical and Health Sciences 1117 Public Health and Health Services 17 Psychology and Cognitive Sciences 1701 Psychology

Thomas Folkmann Hansen^*
, Louise K. Hoeffding
, Lisette Kogelman
, Thilde Marie Haspang
, Henrik Ullum
, Erik Sørensen
, Christian Erikstrup
, Ole Birger Pedersen
, Kaspar René Nielsen
, Henrik Hjalgrim
, Helene M. Paarup
, Thomas Werge
, Kristoffer Burgdorf

^*Corresponding author for this work

Clinical Immunology

Research output: Contribution to journal › Article › Research › peer-review

Abstract

Background: Migraine and Attention Deficit and Hyperactivity Disorder (ADHD) have been found to be associated in child and adolescent cohorts; however, the association has not been assessed in adults or otherwise healthy population. Assessing the comorbidity between ADHD and migraine may clarify the etiopathology of both diseases. Thus, the objective is to assess whether migraine (with and without visual disturbances) and ADHD are comorbid disorders. Methods: Participants from the Danish Blood Donor Study (N = 26,456, age 18-65, 46% female) were assessed for migraine and ADHD using the ASRS ver 1.1 clinically validated questionnaire and self-reported migraine in a cross-sectional study. Logistic regression was used to examine the comorbidity between migraine and ADHD, and their associated endophenotypes. Results: Migraine was strongly associated with ADHD (OR = 1.8, 95% CI = 1.5-2.1), (238/6152 vs 690/19,376). There was a significant interaction between age and gender, with comorbidity increasing with age and female sex. Post-hoc analysis showed that migraine with visual disturbance was generally associated with a marginally higher risk of ADHD and this was independent of ADHD endophenotypes. Conclusion: Migraine and ADHD were demonstrated to be comorbid disorders; the association with ADHD was most prominent for participants with migraine with visual disturbances. Future studies will elucidate which genetic and environmental factors contribute to migraine-ADHD comorbidity.

Original language	English
Article number	147
Journal	BMC Neurology
Volume	18
Issue number	1
DOIs	https://doi.org/10.1186/s12883-018-1149-6
Publication status	Published - 16 Oct 2018

Funding

This work was supported by RegionH research foundation (R129-A3973 to Dr. Hansen); Candy foundation CEHEAD (Prof Jes Olesen, Co-PI Dr. Hansen); the Lundbeck Foundation, Denmark under Grant (R219–2016–1030 to Dr. Hoeffding); The Danish Council for Independent Research - Medical Sciences under Grant (1333-00275A to Dr. Burgdorf and 09–069412); The Danish Administrative Regions; The Danish Administrative Regions’ Bio-and Genome Bank; and The Danish Blood Donor Research Foundation (Bloddonorernes Forskningsfond). The funders had no role in study design, data collection, and analysis, decision to publish, or preparation of the manuscript.

Keywords

Attention deficiency and hyperactivity disorder
Comorbidity
Migraine

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10.1186/s12883-018-1149-6

Cite this

Hansen, T. F., Hoeffding, L. K., Kogelman, L., Haspang, T. M., Ullum, H., Sørensen, E., Erikstrup, C., Pedersen, O. B., Nielsen, K. R., Hjalgrim, H., Paarup, H. M., Werge, T., & Burgdorf, K. (2018). Comorbidity of migraine with ADHD in adults 11 Medical and Health Sciences 1117 Public Health and Health Services 17 Psychology and Cognitive Sciences 1701 Psychology. BMC Neurology, 18(1), Article 147. https://doi.org/10.1186/s12883-018-1149-6

@article{2ff125f66b7d4da69a6ddda988761194,

title = "Comorbidity of migraine with ADHD in adults 11 Medical and Health Sciences 1117 Public Health and Health Services 17 Psychology and Cognitive Sciences 1701 Psychology",

abstract = "Background: Migraine and Attention Deficit and Hyperactivity Disorder (ADHD) have been found to be associated in child and adolescent cohorts; however, the association has not been assessed in adults or otherwise healthy population. Assessing the comorbidity between ADHD and migraine may clarify the etiopathology of both diseases. Thus, the objective is to assess whether migraine (with and without visual disturbances) and ADHD are comorbid disorders. Methods: Participants from the Danish Blood Donor Study (N = 26,456, age 18-65, 46\% female) were assessed for migraine and ADHD using the ASRS ver 1.1 clinically validated questionnaire and self-reported migraine in a cross-sectional study. Logistic regression was used to examine the comorbidity between migraine and ADHD, and their associated endophenotypes. Results: Migraine was strongly associated with ADHD (OR = 1.8, 95\% CI = 1.5-2.1), (238/6152 vs 690/19,376). There was a significant interaction between age and gender, with comorbidity increasing with age and female sex. Post-hoc analysis showed that migraine with visual disturbance was generally associated with a marginally higher risk of ADHD and this was independent of ADHD endophenotypes. Conclusion: Migraine and ADHD were demonstrated to be comorbid disorders; the association with ADHD was most prominent for participants with migraine with visual disturbances. Future studies will elucidate which genetic and environmental factors contribute to migraine-ADHD comorbidity.",

keywords = "Attention deficiency and hyperactivity disorder, Comorbidity, Migraine",

author = "Hansen, \{Thomas Folkmann\} and Hoeffding, \{Louise K.\} and Lisette Kogelman and Haspang, \{Thilde Marie\} and Henrik Ullum and Erik S{\o}rensen and Christian Erikstrup and Pedersen, \{Ole Birger\} and Nielsen, \{Kaspar Ren{\'e}\} and Henrik Hjalgrim and Paarup, \{Helene M.\} and Thomas Werge and Kristoffer Burgdorf",

year = "2018",

month = oct,

day = "16",

doi = "10.1186/s12883-018-1149-6",

language = "English",

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journal = "BMC Neurology",

issn = "1471-2377",

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Hansen, TF, Hoeffding, LK, Kogelman, L, Haspang, TM, Ullum, H, Sørensen, E, Erikstrup, C, Pedersen, OB, Nielsen, KR, Hjalgrim, H, Paarup, HM, Werge, T & Burgdorf, K 2018, 'Comorbidity of migraine with ADHD in adults 11 Medical and Health Sciences 1117 Public Health and Health Services 17 Psychology and Cognitive Sciences 1701 Psychology', BMC Neurology, vol. 18, no. 1, 147. https://doi.org/10.1186/s12883-018-1149-6

Comorbidity of migraine with ADHD in adults 11 Medical and Health Sciences 1117 Public Health and Health Services 17 Psychology and Cognitive Sciences 1701 Psychology. / Hansen, Thomas Folkmann; Hoeffding, Louise K.; Kogelman, Lisette et al.
In: BMC Neurology, Vol. 18, No. 1, 147, 16.10.2018.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - Comorbidity of migraine with ADHD in adults 11 Medical and Health Sciences 1117 Public Health and Health Services 17 Psychology and Cognitive Sciences 1701 Psychology

AU - Hansen, Thomas Folkmann

AU - Hoeffding, Louise K.

AU - Kogelman, Lisette

AU - Haspang, Thilde Marie

AU - Ullum, Henrik

AU - Sørensen, Erik

AU - Erikstrup, Christian

AU - Pedersen, Ole Birger

AU - Nielsen, Kaspar René

AU - Hjalgrim, Henrik

AU - Paarup, Helene M.

AU - Werge, Thomas

AU - Burgdorf, Kristoffer

PY - 2018/10/16

Y1 - 2018/10/16

N2 - Background: Migraine and Attention Deficit and Hyperactivity Disorder (ADHD) have been found to be associated in child and adolescent cohorts; however, the association has not been assessed in adults or otherwise healthy population. Assessing the comorbidity between ADHD and migraine may clarify the etiopathology of both diseases. Thus, the objective is to assess whether migraine (with and without visual disturbances) and ADHD are comorbid disorders. Methods: Participants from the Danish Blood Donor Study (N = 26,456, age 18-65, 46% female) were assessed for migraine and ADHD using the ASRS ver 1.1 clinically validated questionnaire and self-reported migraine in a cross-sectional study. Logistic regression was used to examine the comorbidity between migraine and ADHD, and their associated endophenotypes. Results: Migraine was strongly associated with ADHD (OR = 1.8, 95% CI = 1.5-2.1), (238/6152 vs 690/19,376). There was a significant interaction between age and gender, with comorbidity increasing with age and female sex. Post-hoc analysis showed that migraine with visual disturbance was generally associated with a marginally higher risk of ADHD and this was independent of ADHD endophenotypes. Conclusion: Migraine and ADHD were demonstrated to be comorbid disorders; the association with ADHD was most prominent for participants with migraine with visual disturbances. Future studies will elucidate which genetic and environmental factors contribute to migraine-ADHD comorbidity.

AB - Background: Migraine and Attention Deficit and Hyperactivity Disorder (ADHD) have been found to be associated in child and adolescent cohorts; however, the association has not been assessed in adults or otherwise healthy population. Assessing the comorbidity between ADHD and migraine may clarify the etiopathology of both diseases. Thus, the objective is to assess whether migraine (with and without visual disturbances) and ADHD are comorbid disorders. Methods: Participants from the Danish Blood Donor Study (N = 26,456, age 18-65, 46% female) were assessed for migraine and ADHD using the ASRS ver 1.1 clinically validated questionnaire and self-reported migraine in a cross-sectional study. Logistic regression was used to examine the comorbidity between migraine and ADHD, and their associated endophenotypes. Results: Migraine was strongly associated with ADHD (OR = 1.8, 95% CI = 1.5-2.1), (238/6152 vs 690/19,376). There was a significant interaction between age and gender, with comorbidity increasing with age and female sex. Post-hoc analysis showed that migraine with visual disturbance was generally associated with a marginally higher risk of ADHD and this was independent of ADHD endophenotypes. Conclusion: Migraine and ADHD were demonstrated to be comorbid disorders; the association with ADHD was most prominent for participants with migraine with visual disturbances. Future studies will elucidate which genetic and environmental factors contribute to migraine-ADHD comorbidity.

KW - Attention deficiency and hyperactivity disorder

KW - Comorbidity

KW - Migraine

UR - https://www.scopus.com/pages/publications/85054892001

U2 - 10.1186/s12883-018-1149-6

DO - 10.1186/s12883-018-1149-6

M3 - Article

C2 - 30322380

AN - SCOPUS:85054892001

SN - 1471-2377

VL - 18

JO - BMC Neurology

JF - BMC Neurology

IS - 1

M1 - 147

ER -

Comorbidity of migraine with ADHD in adults 11 Medical and Health Sciences 1117 Public Health and Health Services 17 Psychology and Cognitive Sciences 1701 Psychology

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