Cohort profile: Copenhagen Hospital Biobank-chronic inflammatory disease-inflammatory bowel disease (CHB-CID:IBD) genetic cohort

Behrooz Darbani; Thorsten Brodersen; Anette Liljensøe; Signe Bek Sørensen; Josephine Bjergbæk Olsson-Svendsen; Alfonso Buil; Ahmed Kamal; Andrew J Schork; Anja Poulsen; Bertram Dalskov Kjerulff; Bitten Aagaard; Britta Ørnfelt Lund; Charlotte Siggaard Rittig; Christina Mikkelsen; Daniel Millencourt Larsen; David Westergaard; Ditte Rudbeck-Resdal; Dorte Helenius Mikkelsen; Else Randers; Frank Vinholt Schiødt; Hans Jürgen Hoffmann; Isabella Friis Jørgensen; Ivan Brandslund; Jacob Broder Brodersen; Jakob Hjorth von Stemann; Jakob Thaning Bay; Janna Nissen; Jeanette Sørensen; Jens Kjærgaard Boldsen; Joseph Dowsett; Josephine Gladov; Karina Banasik; Kathrine Agergård Kaspersen; Katrine Carlsen; Khoa Manh Dinh; Lauge Kellermann; Lea Arregui Nordahl Christoffersen; Liam James Elgaard Quinn; Lise Wegner Thørner; Lone Larsen; Luise Aamann; Malene Rohr Andersen; Maria Didriksen; Maria Joanna Alexandraki; Marianne Kragh Thomsen; Mette Julsgaard; Mette Nyegaard; Michael Schwinn; Mie Topholm-Bruun; Mikael Njai Leite; Morten Lee Halling; Natalia Pedersen; Ole K Bonderup; Palle Duun Rohde; Pernille Dige Ovesen; Ram Benny Dessau; Sanaz Saboori; Sofie Holm-Christensen; Steffen Bank; Susan Mikkelsen; Thomas Folkmann Hansen; Thomas Werge; Niels Qvist; Erik Sørensen; Johan Burisch; Merete Lund Hetland; Bente Glintborg; Christian Erikstrup; Søren Brunak; Henrik Ullum; Sisse Rye Ostrowski; Ole Birger Vesterager Pedersen; Vibeke Andersen

doi:10.1007/s10654-025-01239-4

Cohort profile: Copenhagen Hospital Biobank-chronic inflammatory disease-inflammatory bowel disease (CHB-CID:IBD) genetic cohort

Behrooz Darbani^*
, Thorsten Brodersen
, Anette Liljensøe
, Signe Bek Sørensen
, Josephine Bjergbæk Olsson-Svendsen
, Alfonso Buil
, Ahmed Kamal
, Andrew J Schork
, Anja Poulsen
, Bertram Dalskov Kjerulff
, Bitten Aagaard
, Britta Ørnfelt Lund
, Charlotte Siggaard Rittig
, Christina Mikkelsen
, Daniel Millencourt Larsen
, David Westergaard
, Ditte Rudbeck-Resdal
, Dorte Helenius Mikkelsen
, Else Randers
, Frank Vinholt Schiødt

Hans Jürgen Hoffmann, Isabella Friis Jørgensen, Ivan Brandslund, Jacob Broder Brodersen, Jakob Hjorth von Stemann, Jakob Thaning Bay, Janna Nissen, Jeanette Sørensen, Jens Kjærgaard Boldsen, Joseph Dowsett, Josephine Gladov, Karina Banasik, Kathrine Agergård Kaspersen, Katrine Carlsen, Khoa Manh Dinh, Lauge Kellermann, Lea Arregui Nordahl Christoffersen, Liam James Elgaard Quinn, Lise Wegner Thørner, Lone Larsen, Luise Aamann, Malene Rohr Andersen, Maria Didriksen, Maria Joanna Alexandraki, Marianne Kragh Thomsen, Mette Julsgaard, Mette Nyegaard, Michael Schwinn, Mie Topholm-Bruun, Mikael Njai Leite, Morten Lee Halling, Natalia Pedersen, Ole K Bonderup, Palle Duun Rohde, Pernille Dige Ovesen, Ram Benny Dessau, Sanaz Saboori, Sofie Holm-Christensen, Steffen Bank, Susan Mikkelsen, Thomas Folkmann Hansen, Thomas Werge, Niels Qvist, Erik Sørensen, Johan Burisch, Merete Lund Hetland, Bente Glintborg, Christian Erikstrup, Søren Brunak, Henrik Ullum, Sisse Rye Ostrowski, Ole Birger Vesterager Pedersen, Vibeke Andersen

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

Abstract

The Copenhagen Hospital Biobank-chronic inflammatory disease-inflammatory bowel disease (CHB-CID: IBD) cohort contributes to genetic research in inflammatory bowel disease, including Crohn's disease and ulcerative colitis. Of the 327,084 enrolled and genotyped individuals in the cohort, 10,626 have been diagnosed with IBD as of May 2023. The CHB-CID: IBD cohort includes both patients without IBD and healthy blood donors as control groups. Clinical data is collected from Danish registries and patient records, including details on hospital contacts, co-morbidities, medication, surgical procedures, and laboratory investigations. The cohort features a wide age range (> 18 years), extensive population coverage representative of Danish adults, and validated IBD diagnoses. Finally, the cohort benefits from continuous recruitment and regular updates of clinical information. The aim is to enhance IBD management and ultimately improve patients' quality of life.

Original language	English
Pages (from-to)	721-734
Number of pages	14
Journal	European Journal of Epidemiology
Volume	40
Issue number	6
Early online date	9 Jun 2025
DOIs	https://doi.org/10.1007/s10654-025-01239-4
Publication status	Published - Jun 2025

Funding

We thank all the participating patients and blood donors who participate in DBDS, collaborating partners, blood centers, and the Danish hospitals for their valuable contributions. We thank deCODE genetic-Iceland for genotyping and imputation. S & oslash;ren Brunak acknowledges Novo Nordisk Foundation (grants NNF17OC0027594 and NNF14CC0001). The authors wish to thank Ditlev Nytoft Rasmussen, Miriam Viktov Thygesen, and Gitte B. Fuusager for his contribution to TARCID.

Funders	Funder number
Novo Nordisk Foundation	NNF17OC0027594, NNF14CC0001

Keywords

Adolescent
Adult
Aged
Biological Specimen Banks
Chronic Disease
Cohort Studies
Colitis, Ulcerative/genetics
Crohn Disease/genetics
Denmark/epidemiology
Female
Humans
Inflammatory Bowel Diseases/genetics
Male
Middle Aged
Registries
Young Adult

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Darbani, B., Brodersen, T., Liljensøe, A., Sørensen, S. B., Olsson-Svendsen, J. B., Buil, A., Kamal, A., Schork, A. J., Poulsen, A., Kjerulff, B. D., Aagaard, B., Lund, B. Ø., Rittig, C. S., Mikkelsen, C., Larsen, D. M., Westergaard, D., Rudbeck-Resdal, D., Mikkelsen, D. H., Randers, E., ... Andersen, V. (2025). Cohort profile: Copenhagen Hospital Biobank-chronic inflammatory disease-inflammatory bowel disease (CHB-CID:IBD) genetic cohort. European Journal of Epidemiology, 40(6), 721-734. https://doi.org/10.1007/s10654-025-01239-4

@article{e487ae2df7084c4bb1d65570f7f58760,

title = "Cohort profile: Copenhagen Hospital Biobank-chronic inflammatory disease-inflammatory bowel disease (CHB-CID:IBD) genetic cohort",

abstract = "The Copenhagen Hospital Biobank-chronic inflammatory disease-inflammatory bowel disease (CHB-CID: IBD) cohort contributes to genetic research in inflammatory bowel disease, including Crohn's disease and ulcerative colitis. Of the 327,084 enrolled and genotyped individuals in the cohort, 10,626 have been diagnosed with IBD as of May 2023. The CHB-CID: IBD cohort includes both patients without IBD and healthy blood donors as control groups. Clinical data is collected from Danish registries and patient records, including details on hospital contacts, co-morbidities, medication, surgical procedures, and laboratory investigations. The cohort features a wide age range (> 18 years), extensive population coverage representative of Danish adults, and validated IBD diagnoses. Finally, the cohort benefits from continuous recruitment and regular updates of clinical information. The aim is to enhance IBD management and ultimately improve patients' quality of life.",

keywords = "Adolescent, Adult, Aged, Biological Specimen Banks, Chronic Disease, Cohort Studies, Colitis, Ulcerative/genetics, Crohn Disease/genetics, Denmark/epidemiology, Female, Humans, Inflammatory Bowel Diseases/genetics, Male, Middle Aged, Registries, Young Adult",

author = "Behrooz Darbani and Thorsten Brodersen and Anette Liljens{\o}e and S{\o}rensen, \{Signe Bek\} and Olsson-Svendsen, \{Josephine Bjergb{\ae}k\} and Alfonso Buil and Ahmed Kamal and Schork, \{Andrew J\} and Anja Poulsen and Kjerulff, \{Bertram Dalskov\} and Bitten Aagaard and Lund, \{Britta {\O}rnfelt\} and Rittig, \{Charlotte Siggaard\} and Christina Mikkelsen and Larsen, \{Daniel Millencourt\} and David Westergaard and Ditte Rudbeck-Resdal and Mikkelsen, \{Dorte Helenius\} and Else Randers and Schi{\o}dt, \{Frank Vinholt\} and Hoffmann, \{Hans J{\"u}rgen\} and J{\o}rgensen, \{Isabella Friis\} and Ivan Brandslund and Brodersen, \{Jacob Broder\} and \{von Stemann\}, \{Jakob Hjorth\} and Bay, \{Jakob Thaning\} and Janna Nissen and Jeanette S{\o}rensen and Boldsen, \{Jens Kj{\ae}rgaard\} and Joseph Dowsett and Josephine Gladov and Karina Banasik and Kaspersen, \{Kathrine Agerg{\aa}rd\} and Katrine Carlsen and Dinh, \{Khoa Manh\} and Lauge Kellermann and Christoffersen, \{Lea Arregui Nordahl\} and Quinn, \{Liam James Elgaard\} and Th{\o}rner, \{Lise Wegner\} and Lone Larsen and Luise Aamann and Andersen, \{Malene Rohr\} and Maria Didriksen and Alexandraki, \{Maria Joanna\} and Thomsen, \{Marianne Kragh\} and Mette Julsgaard and Mette Nyegaard and Michael Schwinn and Mie Topholm-Bruun and Leite, \{Mikael Njai\} and Halling, \{Morten Lee\} and Natalia Pedersen and Bonderup, \{Ole K\} and Rohde, \{Palle Duun\} and Ovesen, \{Pernille Dige\} and Dessau, \{Ram Benny\} and Sanaz Saboori and Sofie Holm-Christensen and Steffen Bank and Susan Mikkelsen and Hansen, \{Thomas Folkmann\} and Thomas Werge and Niels Qvist and Erik S{\o}rensen and Johan Burisch and Hetland, \{Merete Lund\} and Bente Glintborg and Christian Erikstrup and S{\o}ren Brunak and Henrik Ullum and Ostrowski, \{Sisse Rye\} and Pedersen, \{Ole Birger Vesterager\} and Vibeke Andersen",

note = "{\textcopyright} 2025. The Author(s).",

year = "2025",

month = jun,

doi = "10.1007/s10654-025-01239-4",

language = "English",

volume = "40",

pages = "721--734",

journal = "European Journal of Epidemiology",

issn = "0393-2990",

publisher = "Springer Science and Business Media B.V.",

number = "6",

}

Darbani, B, Brodersen, T, Liljensøe, A, Sørensen, SB, Olsson-Svendsen, JB, Buil, A, Kamal, A, Schork, AJ, Poulsen, A, Kjerulff, BD, Aagaard, B, Lund, BØ, Rittig, CS, Mikkelsen, C, Larsen, DM, Westergaard, D, Rudbeck-Resdal, D, Mikkelsen, DH, Randers, E, Schiødt, FV, Hoffmann, HJ, Jørgensen, IF, Brandslund, I, Brodersen, JB, von Stemann, JH, Bay, JT, Nissen, J, Sørensen, J, Boldsen, JK, Dowsett, J, Gladov, J, Banasik, K, Kaspersen, KA, Carlsen, K, Dinh, KM, Kellermann, L, Christoffersen, LAN, Quinn, LJE, Thørner, LW, Larsen, L, Aamann, L, Andersen, MR, Didriksen, M, Alexandraki, MJ, Thomsen, MK, Julsgaard, M, Nyegaard, M, Schwinn, M, Topholm-Bruun, M, Leite, MN, Halling, ML, Pedersen, N, Bonderup, OK, Rohde, PD, Ovesen, PD, Dessau, RB , Saboori, S, Holm-Christensen, S, Bank, S, Mikkelsen, S, Hansen, TF, Werge, T, Qvist, N, Sørensen, E, Burisch, J, Hetland, ML, Glintborg, B, Erikstrup, C, Brunak, S, Ullum, H, Ostrowski, SR, Pedersen, OBV & Andersen, V 2025, 'Cohort profile: Copenhagen Hospital Biobank-chronic inflammatory disease-inflammatory bowel disease (CHB-CID:IBD) genetic cohort', European Journal of Epidemiology, vol. 40, no. 6, pp. 721-734. https://doi.org/10.1007/s10654-025-01239-4

TY - JOUR

T1 - Cohort profile

T2 - Copenhagen Hospital Biobank-chronic inflammatory disease-inflammatory bowel disease (CHB-CID:IBD) genetic cohort

AU - Darbani, Behrooz

AU - Brodersen, Thorsten

AU - Liljensøe, Anette

AU - Sørensen, Signe Bek

AU - Olsson-Svendsen, Josephine Bjergbæk

AU - Buil, Alfonso

AU - Kamal, Ahmed

AU - Schork, Andrew J

AU - Poulsen, Anja

AU - Kjerulff, Bertram Dalskov

AU - Aagaard, Bitten

AU - Lund, Britta Ørnfelt

AU - Rittig, Charlotte Siggaard

AU - Mikkelsen, Christina

AU - Larsen, Daniel Millencourt

AU - Westergaard, David

AU - Rudbeck-Resdal, Ditte

AU - Mikkelsen, Dorte Helenius

AU - Randers, Else

AU - Schiødt, Frank Vinholt

AU - Hoffmann, Hans Jürgen

AU - Jørgensen, Isabella Friis

AU - Brandslund, Ivan

AU - Brodersen, Jacob Broder

AU - von Stemann, Jakob Hjorth

AU - Bay, Jakob Thaning

AU - Nissen, Janna

AU - Sørensen, Jeanette

AU - Boldsen, Jens Kjærgaard

AU - Dowsett, Joseph

AU - Gladov, Josephine

AU - Banasik, Karina

AU - Kaspersen, Kathrine Agergård

AU - Carlsen, Katrine

AU - Dinh, Khoa Manh

AU - Kellermann, Lauge

AU - Christoffersen, Lea Arregui Nordahl

AU - Quinn, Liam James Elgaard

AU - Thørner, Lise Wegner

AU - Larsen, Lone

AU - Aamann, Luise

AU - Andersen, Malene Rohr

AU - Didriksen, Maria

AU - Alexandraki, Maria Joanna

AU - Thomsen, Marianne Kragh

AU - Julsgaard, Mette

AU - Nyegaard, Mette

AU - Schwinn, Michael

AU - Topholm-Bruun, Mie

AU - Leite, Mikael Njai

AU - Halling, Morten Lee

AU - Pedersen, Natalia

AU - Bonderup, Ole K

AU - Rohde, Palle Duun

AU - Ovesen, Pernille Dige

AU - Dessau, Ram Benny

AU - Saboori, Sanaz

AU - Holm-Christensen, Sofie

AU - Bank, Steffen

AU - Mikkelsen, Susan

AU - Hansen, Thomas Folkmann

AU - Werge, Thomas

AU - Qvist, Niels

AU - Sørensen, Erik

AU - Burisch, Johan

AU - Hetland, Merete Lund

AU - Glintborg, Bente

AU - Erikstrup, Christian

AU - Brunak, Søren

AU - Ullum, Henrik

AU - Ostrowski, Sisse Rye

AU - Pedersen, Ole Birger Vesterager

AU - Andersen, Vibeke

PY - 2025/6

Y1 - 2025/6

N2 - The Copenhagen Hospital Biobank-chronic inflammatory disease-inflammatory bowel disease (CHB-CID: IBD) cohort contributes to genetic research in inflammatory bowel disease, including Crohn's disease and ulcerative colitis. Of the 327,084 enrolled and genotyped individuals in the cohort, 10,626 have been diagnosed with IBD as of May 2023. The CHB-CID: IBD cohort includes both patients without IBD and healthy blood donors as control groups. Clinical data is collected from Danish registries and patient records, including details on hospital contacts, co-morbidities, medication, surgical procedures, and laboratory investigations. The cohort features a wide age range (> 18 years), extensive population coverage representative of Danish adults, and validated IBD diagnoses. Finally, the cohort benefits from continuous recruitment and regular updates of clinical information. The aim is to enhance IBD management and ultimately improve patients' quality of life.

AB - The Copenhagen Hospital Biobank-chronic inflammatory disease-inflammatory bowel disease (CHB-CID: IBD) cohort contributes to genetic research in inflammatory bowel disease, including Crohn's disease and ulcerative colitis. Of the 327,084 enrolled and genotyped individuals in the cohort, 10,626 have been diagnosed with IBD as of May 2023. The CHB-CID: IBD cohort includes both patients without IBD and healthy blood donors as control groups. Clinical data is collected from Danish registries and patient records, including details on hospital contacts, co-morbidities, medication, surgical procedures, and laboratory investigations. The cohort features a wide age range (> 18 years), extensive population coverage representative of Danish adults, and validated IBD diagnoses. Finally, the cohort benefits from continuous recruitment and regular updates of clinical information. The aim is to enhance IBD management and ultimately improve patients' quality of life.

KW - Adolescent

KW - Adult

KW - Aged

KW - Biological Specimen Banks

KW - Chronic Disease

KW - Cohort Studies

KW - Colitis, Ulcerative/genetics

KW - Crohn Disease/genetics

KW - Denmark/epidemiology

KW - Female

KW - Humans

KW - Inflammatory Bowel Diseases/genetics

KW - Male

KW - Middle Aged

KW - Registries

KW - Young Adult

U2 - 10.1007/s10654-025-01239-4

DO - 10.1007/s10654-025-01239-4

M3 - Article

C2 - 40488802

SN - 0393-2990

VL - 40

SP - 721

EP - 734

JO - European Journal of Epidemiology

JF - European Journal of Epidemiology

IS - 6

ER -

Cohort profile: Copenhagen Hospital Biobank-chronic inflammatory disease-inflammatory bowel disease (CHB-CID:IBD) genetic cohort

Abstract

Funding

Keywords

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