Chemokine receptor expression on B cells and effect of interferon-β in multiple sclerosis

Torben L. Sorensen; Hanne Roed; Finn Sellebjerg

doi:10.1016/S0165-5728(01)00453-2

Chemokine receptor expression on B cells and effect of interferon-β in multiple sclerosis

Torben L. Sorensen^*
, Hanne Roed
, Finn Sellebjerg

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

Abstract

We investigated the B-cell expression of chemokine receptors CXCR3, CXCR5 and CCR5 in the blood and cerebrospinal fluid (CSF) from patients in relapse of multiple sclerosis (MS) and in neurological controls. Chemokine receptor expression was also studied in interferon-β-treated patients with relapsing-remitting or secondary progressive MS. We observed significantly higher expression of CXCR3 on B cells in the CSF in active MS than in controls. Patients with active MS also had higher B-cell expression of CCR5 in blood. No major differences between RRMS and SPMS patients were detected, and chemokine receptor expression was not affected by interferon-β treatment.

Original language	English
Pages (from-to)	125-131
Number of pages	7
Journal	Journal of Neuroimmunology
Volume	122
Issue number	1-2
DOIs	https://doi.org/10.1016/S0165-5728(01)00453-2
Publication status	Published - 29 Jan 2002

Funding

We thank Anne Petersen for technical assistance, and Lene Bangsgaard, RN for the coordination of patient referrals. The Danish Multiple Sclerosis Society, Desiree and Niels Yde's Foundation, the Beckett Foundation, the Toyota Foundation, and Dagmar Marshall's Foundation supported this work.

Keywords

B cells
Chemokine receptors
Demyelinating disease
Multiple sclerosis

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10.1016/S0165-5728(01)00453-2

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title = "Chemokine receptor expression on B cells and effect of interferon-β in multiple sclerosis",

abstract = "We investigated the B-cell expression of chemokine receptors CXCR3, CXCR5 and CCR5 in the blood and cerebrospinal fluid (CSF) from patients in relapse of multiple sclerosis (MS) and in neurological controls. Chemokine receptor expression was also studied in interferon-β-treated patients with relapsing-remitting or secondary progressive MS. We observed significantly higher expression of CXCR3 on B cells in the CSF in active MS than in controls. Patients with active MS also had higher B-cell expression of CCR5 in blood. No major differences between RRMS and SPMS patients were detected, and chemokine receptor expression was not affected by interferon-β treatment.",

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AU - Roed, Hanne

AU - Sellebjerg, Finn

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N2 - We investigated the B-cell expression of chemokine receptors CXCR3, CXCR5 and CCR5 in the blood and cerebrospinal fluid (CSF) from patients in relapse of multiple sclerosis (MS) and in neurological controls. Chemokine receptor expression was also studied in interferon-β-treated patients with relapsing-remitting or secondary progressive MS. We observed significantly higher expression of CXCR3 on B cells in the CSF in active MS than in controls. Patients with active MS also had higher B-cell expression of CCR5 in blood. No major differences between RRMS and SPMS patients were detected, and chemokine receptor expression was not affected by interferon-β treatment.

AB - We investigated the B-cell expression of chemokine receptors CXCR3, CXCR5 and CCR5 in the blood and cerebrospinal fluid (CSF) from patients in relapse of multiple sclerosis (MS) and in neurological controls. Chemokine receptor expression was also studied in interferon-β-treated patients with relapsing-remitting or secondary progressive MS. We observed significantly higher expression of CXCR3 on B cells in the CSF in active MS than in controls. Patients with active MS also had higher B-cell expression of CCR5 in blood. No major differences between RRMS and SPMS patients were detected, and chemokine receptor expression was not affected by interferon-β treatment.

KW - B cells

KW - Chemokine receptors

KW - Demyelinating disease

KW - Multiple sclerosis

UR - https://www.scopus.com/pages/publications/0036147311

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JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

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ER -

Chemokine receptor expression on B cells and effect of interferon-β in multiple sclerosis

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