Characteristics of healthy vascular ageing in pooled population-based cohort studies: The global metabolic syndrome and artery research consortium

Peter M. Nilsson; Stephane Laurent; Pedro G. Cunha; Michael H. Olsen; Ernst Rietzschel; Oscar H. Franco; Ligita Ryliškyte; Irina Strazhesko; Charalambos Vlachopoulos; Chen Huan Chen; Pierre Boutouyrie; Francesco Cucca; Edward G. Lakatta; Angelo Scuteri; Metabolic syndrome, Arteries REsearch (MARE) Consortium

doi:10.1097/HJH.0000000000001824

Characteristics of healthy vascular ageing in pooled population-based cohort studies: The global metabolic syndrome and artery research consortium

Peter M. Nilsson
, Stephane Laurent
, Pedro G. Cunha
, Michael H. Olsen
, Ernst Rietzschel
, Oscar H. Franco
, Ligita Ryliškyte
, Irina Strazhesko
, Charalambos Vlachopoulos
, Chen Huan Chen
, Pierre Boutouyrie
, Francesco Cucca
, Edward G. Lakatta
, Angelo Scuteri^*
, Metabolic syndrome, Arteries REsearch (MARE) Consortium

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

Abstract

Objective: Arterial ageing is characterized by increasing arterial stiffness as measured by pulse wave velocity (PWV) This process is enhanced in participants with early vascular ageing (EVA), but slowed in participants with healthy vascular ageing (HVA). We aimed to describe characteristics of EVA and HVA in a transcontinental study including 11 cohorts. Methods: In all, 18490 participants from the global MAR Consortium, free of cardiovascular disease, participated with data on PWV and cardiometabolic risk factors. We defined HVA as the lowest 10% and EVA as the highest 10% of the standardized PWV distribution, adjusted for age intervals. HVA individuals were compared with the 90% of non-HVA individuals with ANCOVA, adjusted for age, sex and hypertension. Results: The 1723 HVA participants were at the same age as the rest of the population, more likely women (59.4 vs 57.0%), and with significantly lower levels of established cardiovascular risk factors (blood pressure, lipids, glucose). Similarly, the prevalence rate of obesity, diabetes mellitus, hypertension and the metabolic syndrome was lower in the HVA participants. In the presence of similar levels of cardiovascular risk factors, HVA participants in the 50-64 years of age group presented lower PWV 5.8 (SD 0.5) vs. 7.4 (1.4) m/s (P<0.0001) than control individuals in the 35-49 years of age group, corresponding to an estimated difference in chronological age of 14 years. Conclusion: Participants with healthy vascular ageing (HVA), belonging to the lowest end of the PWV distribution, are in general characterized by an up to 14 years estimated younger biological (vascular) age than those with higher PWV values, and have lower levels of risk factors.

Original language	English
Pages (from-to)	2340-2349
Number of pages	10
Journal	Journal of Hypertension
Volume	36
Issue number	12
DOIs	https://doi.org/10.1097/HJH.0000000000001824
Publication status	Published - 1 Jan 2018

Funding

Financial support: The Asklepios Study is supported by the Fund for Scientific Research – Flanders (FWO research grants G042703 and G083810N). The Rotterdam Study is supported by the Erasmus Medical Center and Erasmus University Rotterdam; the Netherlands Organization for Scientific Research; the Netherlands Organization for Health Research and Development (ZonMw); the Research Institute for Diseases in the Elderly (RIDE); the Netherlands Heart Foundation; the Ministry of Education, Culture and Science; the Ministry of Health Welfare and Sports; the European Commission; and the Municipality of Rotterdam. The SardiNIA team was supported by Contract NO1-AG-1–2109 from the NIA. This research was supported in part by the Intramural Research Program of the NIH, National Institute on Aging (USA). The Baltimore Longitudinal Study of Aging (BLSA) is supported in part by the Intramural Research Program of the NIH, National Institute on Aging. The Kingmen Aging Study was supported, in part, by a grant from the National Science Council (NSC 99-2314-B-010-034-MY3), an intramural grant from the Taipei Veterans General Hospital (grant V102C-119), Research and Development contract NO1-AG-1–2118, and the Intramural Research Program of the National Institute on Aging, National Institutes of Health. The Malmoe Diet Cancer – Cardiovascular Study was supported by grants from the Swedish Research Council (K2008-65X-20752-01-3, K2011-65X-20752-04-6), the Lund-ströms Foundation, the Swedish Heart-Lung Foundation (2010-0244; 2013-0249) and ALF government grants (Dnr: 2012/1789). The Guimarães Study was funded by the Life and Health Research Institute, Medical School, Minho University, Portugal

Keywords

Age
Arterial
Blood pressure
Cohort
Epidemiology
Health
Metabolic syndrome
Risk factor

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10.1097/HJH.0000000000001824

Cite this

Nilsson, P. M., Laurent, S., Cunha, P. G., Olsen, M. H., Rietzschel, E., Franco, O. H., Ryliškyte, L., Strazhesko, I., Vlachopoulos, C., Chen, C. H., Boutouyrie, P., Cucca, F., Lakatta, E. G., Scuteri, A., & Metabolic syndrome, Arteries REsearch (MARE) Consortium (2018). Characteristics of healthy vascular ageing in pooled population-based cohort studies: The global metabolic syndrome and artery research consortium. Journal of Hypertension, 36(12), 2340-2349. https://doi.org/10.1097/HJH.0000000000001824

@article{e7b8e867a52c4c2b94315d92bb93a0ba,

title = "Characteristics of healthy vascular ageing in pooled population-based cohort studies: The global metabolic syndrome and artery research consortium",

abstract = "Objective: Arterial ageing is characterized by increasing arterial stiffness as measured by pulse wave velocity (PWV) This process is enhanced in participants with early vascular ageing (EVA), but slowed in participants with healthy vascular ageing (HVA). We aimed to describe characteristics of EVA and HVA in a transcontinental study including 11 cohorts. Methods: In all, 18490 participants from the global MAR Consortium, free of cardiovascular disease, participated with data on PWV and cardiometabolic risk factors. We defined HVA as the lowest 10\% and EVA as the highest 10\% of the standardized PWV distribution, adjusted for age intervals. HVA individuals were compared with the 90\% of non-HVA individuals with ANCOVA, adjusted for age, sex and hypertension. Results: The 1723 HVA participants were at the same age as the rest of the population, more likely women (59.4 vs 57.0\%), and with significantly lower levels of established cardiovascular risk factors (blood pressure, lipids, glucose). Similarly, the prevalence rate of obesity, diabetes mellitus, hypertension and the metabolic syndrome was lower in the HVA participants. In the presence of similar levels of cardiovascular risk factors, HVA participants in the 50-64 years of age group presented lower PWV 5.8 (SD 0.5) vs. 7.4 (1.4) m/s (P<0.0001) than control individuals in the 35-49 years of age group, corresponding to an estimated difference in chronological age of 14 years. Conclusion: Participants with healthy vascular ageing (HVA), belonging to the lowest end of the PWV distribution, are in general characterized by an up to 14 years estimated younger biological (vascular) age than those with higher PWV values, and have lower levels of risk factors.",

keywords = "Age, Arterial, Blood pressure, Cohort, Epidemiology, Health, Metabolic syndrome, Risk factor",

author = "Nilsson, \{Peter M.\} and Stephane Laurent and Cunha, \{Pedro G.\} and Olsen, \{Michael H.\} and Ernst Rietzschel and Franco, \{Oscar H.\} and Ligita Ryli{\v s}kyte and Irina Strazhesko and Charalambos Vlachopoulos and Chen, \{Chen Huan\} and Pierre Boutouyrie and Francesco Cucca and Lakatta, \{Edward G.\} and Angelo Scuteri and \{Metabolic syndrome, Arteries REsearch (MARE) Consortium\}",

year = "2018",

month = jan,

day = "1",

doi = "10.1097/HJH.0000000000001824",

language = "English",

volume = "36",

pages = "2340--2349",

journal = "Journal of Hypertension",

issn = "0263-6352",

publisher = "Lippincott Williams and Wilkins Ltd.",

number = "12",

}

Nilsson, PM, Laurent, S, Cunha, PG, Olsen, MH, Rietzschel, E, Franco, OH, Ryliškyte, L, Strazhesko, I, Vlachopoulos, C, Chen, CH, Boutouyrie, P, Cucca, F, Lakatta, EG, Scuteri, A & Metabolic syndrome, Arteries REsearch (MARE) Consortium 2018, 'Characteristics of healthy vascular ageing in pooled population-based cohort studies: The global metabolic syndrome and artery research consortium', Journal of Hypertension, vol. 36, no. 12, pp. 2340-2349. https://doi.org/10.1097/HJH.0000000000001824

TY - JOUR

T1 - Characteristics of healthy vascular ageing in pooled population-based cohort studies

T2 - The global metabolic syndrome and artery research consortium

AU - Nilsson, Peter M.

AU - Laurent, Stephane

AU - Cunha, Pedro G.

AU - Olsen, Michael H.

AU - Rietzschel, Ernst

AU - Franco, Oscar H.

AU - Ryliškyte, Ligita

AU - Strazhesko, Irina

AU - Vlachopoulos, Charalambos

AU - Chen, Chen Huan

AU - Boutouyrie, Pierre

AU - Cucca, Francesco

AU - Lakatta, Edward G.

AU - Scuteri, Angelo

AU - Metabolic syndrome, Arteries REsearch (MARE) Consortium

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Objective: Arterial ageing is characterized by increasing arterial stiffness as measured by pulse wave velocity (PWV) This process is enhanced in participants with early vascular ageing (EVA), but slowed in participants with healthy vascular ageing (HVA). We aimed to describe characteristics of EVA and HVA in a transcontinental study including 11 cohorts. Methods: In all, 18490 participants from the global MAR Consortium, free of cardiovascular disease, participated with data on PWV and cardiometabolic risk factors. We defined HVA as the lowest 10% and EVA as the highest 10% of the standardized PWV distribution, adjusted for age intervals. HVA individuals were compared with the 90% of non-HVA individuals with ANCOVA, adjusted for age, sex and hypertension. Results: The 1723 HVA participants were at the same age as the rest of the population, more likely women (59.4 vs 57.0%), and with significantly lower levels of established cardiovascular risk factors (blood pressure, lipids, glucose). Similarly, the prevalence rate of obesity, diabetes mellitus, hypertension and the metabolic syndrome was lower in the HVA participants. In the presence of similar levels of cardiovascular risk factors, HVA participants in the 50-64 years of age group presented lower PWV 5.8 (SD 0.5) vs. 7.4 (1.4) m/s (P<0.0001) than control individuals in the 35-49 years of age group, corresponding to an estimated difference in chronological age of 14 years. Conclusion: Participants with healthy vascular ageing (HVA), belonging to the lowest end of the PWV distribution, are in general characterized by an up to 14 years estimated younger biological (vascular) age than those with higher PWV values, and have lower levels of risk factors.

AB - Objective: Arterial ageing is characterized by increasing arterial stiffness as measured by pulse wave velocity (PWV) This process is enhanced in participants with early vascular ageing (EVA), but slowed in participants with healthy vascular ageing (HVA). We aimed to describe characteristics of EVA and HVA in a transcontinental study including 11 cohorts. Methods: In all, 18490 participants from the global MAR Consortium, free of cardiovascular disease, participated with data on PWV and cardiometabolic risk factors. We defined HVA as the lowest 10% and EVA as the highest 10% of the standardized PWV distribution, adjusted for age intervals. HVA individuals were compared with the 90% of non-HVA individuals with ANCOVA, adjusted for age, sex and hypertension. Results: The 1723 HVA participants were at the same age as the rest of the population, more likely women (59.4 vs 57.0%), and with significantly lower levels of established cardiovascular risk factors (blood pressure, lipids, glucose). Similarly, the prevalence rate of obesity, diabetes mellitus, hypertension and the metabolic syndrome was lower in the HVA participants. In the presence of similar levels of cardiovascular risk factors, HVA participants in the 50-64 years of age group presented lower PWV 5.8 (SD 0.5) vs. 7.4 (1.4) m/s (P<0.0001) than control individuals in the 35-49 years of age group, corresponding to an estimated difference in chronological age of 14 years. Conclusion: Participants with healthy vascular ageing (HVA), belonging to the lowest end of the PWV distribution, are in general characterized by an up to 14 years estimated younger biological (vascular) age than those with higher PWV values, and have lower levels of risk factors.

KW - Age

KW - Arterial

KW - Blood pressure

KW - Cohort

KW - Epidemiology

KW - Health

KW - Metabolic syndrome

KW - Risk factor

UR - https://www.scopus.com/pages/publications/85055840111

U2 - 10.1097/HJH.0000000000001824

DO - 10.1097/HJH.0000000000001824

M3 - Article

C2 - 30063641

AN - SCOPUS:85055840111

SN - 0263-6352

VL - 36

SP - 2340

EP - 2349

JO - Journal of Hypertension

JF - Journal of Hypertension

IS - 12

ER -

Characteristics of healthy vascular ageing in pooled population-based cohort studies: The global metabolic syndrome and artery research consortium

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