Breast cancer with different prognostic characteristics developing in Danish women using hormone replacement therapy

C. Stahlberg; A. T. Pedersen; Z. J. Andersen; N. Keiding; Y. A. Hundrup; E. B. Obel; S. Møller; F. Rank; B. Ottesen; E. Lynge

doi:10.1038/sj.bjc.6601996

Breast cancer with different prognostic characteristics developing in Danish women using hormone replacement therapy

C. Stahlberg^*
, A. T. Pedersen
, Z. J. Andersen
, N. Keiding
, Y. A. Hundrup
, E. B. Obel
, S. Møller
, F. Rank
, B. Ottesen
, E. Lynge

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

Abstract

The aim of this study is to investigate the risk of developing prognostic different types of breast cancer in women using hormone replacement therapy (HRT). A total of 10874 postmenopausal Danish Nurses were followed since 1993. Incident breast cancer cases and histopathological information were retrieved through the National Danish registries. The follow-up ended on 31 December 1999. Breast cancer developed in 244 women, of whom 172 were invasive ductal carcinomas. Compared to never users, current users of HRT had an increased risk of a hormone receptor-positive breast cancer, but a neutral risk of receptor-negative breast cancer, relative risk (RR) 3.29 (95% confidence interval (CI): 2.27-4.77) and RR 0.99 (95% CI: 0.42-2.36), respectively (P for difference = 0.013). The risk of being diagnosed with low histological malignancy grade was higher than high malignancy grade with RR 4.13 (95% CI: 2.43-7.01) and RR 2.17 (95% CI: 1.42-3.30), respectively (P = 0.063). For breast cancers with other prognostic characteristics, the risk was increased equally for the favourable and nonfavourable types. Current users of HRT experience a two- to four-fold increased risk of breast cancer with various prognostic characteristics, both the favourable and nonfavourable types. For receptor status, the risk with HRT was statistically significantly higher for hormone receptor-positive breast cancer compared to receptor-negative breast cancer.

Original language	English
Pages (from-to)	644-650
Number of pages	7
Journal	British Journal of Cancer
Volume	91
Issue number	4
DOIs	https://doi.org/10.1038/sj.bjc.6601996
Publication status	Published - 16 Aug 2004

Funding

The present study is sponsored by The Danish Cancer Society. Ethical approval: The Scientific and Ethical Committee of Frederiksberg and Copenhagen has approved the Danish Nurse Cohort, including analyses in the present study (KF 11-035/00). The Danish Data Protection Agency has been notified and had no objections including the access to the Danish Cancer Registry and National Registry of Hospital Discharges (2001-54-0860). Data are kept by the National Institute of Public Health, Copenhagen. Conflicts of interest: BO and ATP, having an interest in HRT, have been reimbursed by different pharmaceutical industries for speaking at conferences and workshops. The Danish Nurse Cohort has, among others, received financial support by grants from different pharmaceutical industries for costs related to emission of questionnaires and the handling of data.

Keywords

Breast neoplasm
Epidemiology
Hormone replacement therapy
Malignancy grade
Oestrogen
Progestin
Receptor status

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10.1038/sj.bjc.6601996

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title = "Breast cancer with different prognostic characteristics developing in Danish women using hormone replacement therapy",

abstract = "The aim of this study is to investigate the risk of developing prognostic different types of breast cancer in women using hormone replacement therapy (HRT). A total of 10874 postmenopausal Danish Nurses were followed since 1993. Incident breast cancer cases and histopathological information were retrieved through the National Danish registries. The follow-up ended on 31 December 1999. Breast cancer developed in 244 women, of whom 172 were invasive ductal carcinomas. Compared to never users, current users of HRT had an increased risk of a hormone receptor-positive breast cancer, but a neutral risk of receptor-negative breast cancer, relative risk (RR) 3.29 (95\% confidence interval (CI): 2.27-4.77) and RR 0.99 (95\% CI: 0.42-2.36), respectively (P for difference = 0.013). The risk of being diagnosed with low histological malignancy grade was higher than high malignancy grade with RR 4.13 (95\% CI: 2.43-7.01) and RR 2.17 (95\% CI: 1.42-3.30), respectively (P = 0.063). For breast cancers with other prognostic characteristics, the risk was increased equally for the favourable and nonfavourable types. Current users of HRT experience a two- to four-fold increased risk of breast cancer with various prognostic characteristics, both the favourable and nonfavourable types. For receptor status, the risk with HRT was statistically significantly higher for hormone receptor-positive breast cancer compared to receptor-negative breast cancer.",

keywords = "Breast neoplasm, Epidemiology, Hormone replacement therapy, Malignancy grade, Oestrogen, Progestin, Receptor status",

author = "C. Stahlberg and Pedersen, \{A. T.\} and Andersen, \{Z. J.\} and N. Keiding and Hundrup, \{Y. A.\} and Obel, \{E. B.\} and S. M{\o}ller and F. Rank and B. Ottesen and E. Lynge",

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doi = "10.1038/sj.bjc.6601996",

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AU - Stahlberg, C.

AU - Pedersen, A. T.

AU - Andersen, Z. J.

AU - Keiding, N.

AU - Hundrup, Y. A.

AU - Obel, E. B.

AU - Møller, S.

AU - Rank, F.

AU - Ottesen, B.

AU - Lynge, E.

PY - 2004/8/16

Y1 - 2004/8/16

N2 - The aim of this study is to investigate the risk of developing prognostic different types of breast cancer in women using hormone replacement therapy (HRT). A total of 10874 postmenopausal Danish Nurses were followed since 1993. Incident breast cancer cases and histopathological information were retrieved through the National Danish registries. The follow-up ended on 31 December 1999. Breast cancer developed in 244 women, of whom 172 were invasive ductal carcinomas. Compared to never users, current users of HRT had an increased risk of a hormone receptor-positive breast cancer, but a neutral risk of receptor-negative breast cancer, relative risk (RR) 3.29 (95% confidence interval (CI): 2.27-4.77) and RR 0.99 (95% CI: 0.42-2.36), respectively (P for difference = 0.013). The risk of being diagnosed with low histological malignancy grade was higher than high malignancy grade with RR 4.13 (95% CI: 2.43-7.01) and RR 2.17 (95% CI: 1.42-3.30), respectively (P = 0.063). For breast cancers with other prognostic characteristics, the risk was increased equally for the favourable and nonfavourable types. Current users of HRT experience a two- to four-fold increased risk of breast cancer with various prognostic characteristics, both the favourable and nonfavourable types. For receptor status, the risk with HRT was statistically significantly higher for hormone receptor-positive breast cancer compared to receptor-negative breast cancer.

AB - The aim of this study is to investigate the risk of developing prognostic different types of breast cancer in women using hormone replacement therapy (HRT). A total of 10874 postmenopausal Danish Nurses were followed since 1993. Incident breast cancer cases and histopathological information were retrieved through the National Danish registries. The follow-up ended on 31 December 1999. Breast cancer developed in 244 women, of whom 172 were invasive ductal carcinomas. Compared to never users, current users of HRT had an increased risk of a hormone receptor-positive breast cancer, but a neutral risk of receptor-negative breast cancer, relative risk (RR) 3.29 (95% confidence interval (CI): 2.27-4.77) and RR 0.99 (95% CI: 0.42-2.36), respectively (P for difference = 0.013). The risk of being diagnosed with low histological malignancy grade was higher than high malignancy grade with RR 4.13 (95% CI: 2.43-7.01) and RR 2.17 (95% CI: 1.42-3.30), respectively (P = 0.063). For breast cancers with other prognostic characteristics, the risk was increased equally for the favourable and nonfavourable types. Current users of HRT experience a two- to four-fold increased risk of breast cancer with various prognostic characteristics, both the favourable and nonfavourable types. For receptor status, the risk with HRT was statistically significantly higher for hormone receptor-positive breast cancer compared to receptor-negative breast cancer.

KW - Breast neoplasm

KW - Epidemiology

KW - Hormone replacement therapy

KW - Malignancy grade

KW - Oestrogen

KW - Progestin

KW - Receptor status

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EP - 650

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 4

ER -

Breast cancer with different prognostic characteristics developing in Danish women using hormone replacement therapy

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Keywords

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