Automated detection of absence seizures using a wearable electroencephalographic device: a phase-3 validation study and feasibility of automated behavioral testing

Giorgi Japaridze, Dirk Loeckx, Tim Buckinx, Sidsel Armand Larsen, Renée Proost, Katrien Jansen, Paul MacMullin, Natalia Paiva, Sofia Kasradze, Alexander Rotenberg, Lieven Lagae, Sándor Beniczky*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

Abstract

OBJECTIVE: Our primary goal was to measure the accuracy of fully automated absence seizure detection, using a wearable electroencephalographic (EEG) device. As a secondary goal, we also tested the feasibility of automated behavioral testing triggered by the automated detection.

METHODS: We conducted a phase 3 clinical trial (NCT04615442), with a prospective, multicenter, blinded study design. The input was the one-channel EEG recorded with dry electrodes embedded into a wearable headband device connected to a smartphone. The seizure detection algorithm was developed using artificial intelligence (convolutional neural networks). During the study, the predefined algorithm, with predefined cutoff value, analyzed the EEG in real time. The gold standard was derived from expert evaluation of simultaneously recorded full-array video-EEGs. In addition, we evaluated the patients' responsiveness to the automated alarms on the smartphone, and we compared it with the behavioral changes observed in the clinical video-EEGs.

RESULTS: We recorded 102 consecutive patients (57 female, median age = 10 years) on suspicion of absence seizures. We recorded 364 absence seizures in 39 patients. Device deficiency was 4.67%, with a total recording time of 309 h. Average sensitivity per patient was 78.83% (95% confidence interval [CI] = 69.56%-88.11%), and median sensitivity was 92.90% (interquartile range [IQR] = 66.7%-100%). The average false detection rate was .53/h (95% CI = .32-.74). Most patients (n = 66, 64.71%) did not have any false alarms. The median F1 score per patient was .823 (IQR = .57-1). For the total recording duration, F1 score was .74. We assessed the feasibility of automated behavioral testing in 36 seizures; it correctly documented nonresponsiveness in 30 absence seizures, and responsiveness in six electrographic seizures.

SIGNIFICANCE: Automated detection of absence seizures with a wearable device will improve seizure quantification and will promote assessment of patients in their home environment. Linking automated seizure detection to automated behavioral testing will provide valuable information from wearable devices.

Original languageEnglish
Pages (from-to)S40-S46
JournalEpilepsia
Volume64 Suppl 4
Early online date17 Feb 2022
DOIs
Publication statusPublished - Dec 2023

Bibliographical note

© 2022 The Authors. Epilepsia published by Wiley Periodicals LLC on behalf of International League Against Epilepsy.

Keywords

  • absence seizure
  • artificial intelligence
  • automated detection
  • behavioral testing
  • epilepsy
  • wearable devices
  • Seizures/diagnosis
  • Prospective Studies
  • Artificial Intelligence
  • Humans
  • Wearable Electronic Devices
  • Epilepsy, Absence
  • Electroencephalography
  • Feasibility Studies
  • Algorithms
  • Female
  • Child

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