Associations between muscle perfusion and symptoms in knee osteoarthritis: A cross sectional study

E. Bandak; M. Boesen; H. Bliddal; R. G.C. Riis; H. Gudbergsen; M. Henriksen

doi:10.1016/j.joca.2015.05.032

Associations between muscle perfusion and symptoms in knee osteoarthritis: A cross sectional study

E. Bandak^*
, M. Boesen
, H. Bliddal
, R. G.C. Riis
, H. Gudbergsen
, M. Henriksen

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

Abstract

Objective: To investigate the association between muscle perfusion in the peri-articular knee muscles assessed by dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) and symptoms in patients with knee osteoarthritis (KOA). Design: In a cross-sectional setting, muscle perfusion was quantified by DCE-MRI in KOA. Regions of interest (ROI) were drawn around the peri-articular muscles, summed and averaged into one single "Total Muscle Volume" volume of interest (VOI). Symptoms were assessed via the Knee injury and Osteoarthritis Outcome Score (KOOS) (0: worst; 100: best). Results: DCE-MRI and clinical data were analyzed in 94 patients. The typical participant was a woman with a mean age of 65 years, and a body mass index (BMI) of 32 kg/m². Reduced multiple regression models analyzing the association between KOOS and DCE-MRI perfusion variables of Total Muscle Volume showed a statistically significant association between N_voxel% and KOOS pain (0.41 (SE 0.14); P = 0.0048). N_voxel% was defined as the proportion of highly perfused voxels; i.e., the voxels that show an early and rapid increase on the signal intensity vs time curves, reach a plateau state (plateau pattern) and then showing a relatively rapid decline (washout pattern) relative to the total number of voxels within the muscle VOI. Conclusions: More widespread perfusion in the peri-articular knee muscles was associated with less pain in patients with KOA. These results give rise to investigations of the effects of exercise on muscle perfusion and its possible mediating role in the causal pathway between exercise and pain improvements in the conservative management of KOA.

Original language	English
Pages (from-to)	1721-1727
Number of pages	7
Journal	Osteoarthritis and Cartilage
Volume	23
Issue number	10
DOIs	https://doi.org/10.1016/j.joca.2015.05.032
Publication status	Published - 1 Oct 2015

Funding

MB reports grants from The Oak Foundation, grants from Abbvie A/S Denmark, non-financial support from ESAOTE MRI vendor, Genoa Italy, non-financial support from Image Analysis LTD London UK, outside the submitted work; All other authors declare no conflicts of interest. This study was supported by grants from The Danish Physiotherapy Association , The Capital Region of Copenhagen , Bispebjerg-and Frederiksberg Hospitals , The Danish Rheumatism Association , The Oak Foundation , The Velux Foundation , The Cambridge Weight plan UK, The Augustinus Foundation , The A.P.Møller Foundation for the Advancement of Medical Science, Hørslev Fonden, Bjarne Jensens Fond and Aase og Ejnar Danielsens fond.

Keywords

Knee
Magnetic resonance imaging
Muscle perfusion
Osteoarthritis
Symptoms

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10.1016/j.joca.2015.05.032

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@article{988998419b394906920cebae5105e341,

title = "Associations between muscle perfusion and symptoms in knee osteoarthritis: A cross sectional study",

abstract = "Objective: To investigate the association between muscle perfusion in the peri-articular knee muscles assessed by dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) and symptoms in patients with knee osteoarthritis (KOA). Design: In a cross-sectional setting, muscle perfusion was quantified by DCE-MRI in KOA. Regions of interest (ROI) were drawn around the peri-articular muscles, summed and averaged into one single {"}Total Muscle Volume{"} volume of interest (VOI). Symptoms were assessed via the Knee injury and Osteoarthritis Outcome Score (KOOS) (0: worst; 100: best). Results: DCE-MRI and clinical data were analyzed in 94 patients. The typical participant was a woman with a mean age of 65 years, and a body mass index (BMI) of 32 kg/m2. Reduced multiple regression models analyzing the association between KOOS and DCE-MRI perfusion variables of Total Muscle Volume showed a statistically significant association between Nvoxel\% and KOOS pain (0.41 (SE 0.14); P = 0.0048). Nvoxel\% was defined as the proportion of highly perfused voxels; i.e., the voxels that show an early and rapid increase on the signal intensity vs time curves, reach a plateau state (plateau pattern) and then showing a relatively rapid decline (washout pattern) relative to the total number of voxels within the muscle VOI. Conclusions: More widespread perfusion in the peri-articular knee muscles was associated with less pain in patients with KOA. These results give rise to investigations of the effects of exercise on muscle perfusion and its possible mediating role in the causal pathway between exercise and pain improvements in the conservative management of KOA.",

keywords = "Knee, Magnetic resonance imaging, Muscle perfusion, Osteoarthritis, Symptoms",

author = "E. Bandak and M. Boesen and H. Bliddal and Riis, \{R. G.C.\} and H. Gudbergsen and M. Henriksen",

year = "2015",

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doi = "10.1016/j.joca.2015.05.032",

language = "English",

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T1 - Associations between muscle perfusion and symptoms in knee osteoarthritis

T2 - A cross sectional study

AU - Bandak, E.

AU - Boesen, M.

AU - Bliddal, H.

AU - Riis, R. G.C.

AU - Gudbergsen, H.

AU - Henriksen, M.

PY - 2015/10/1

Y1 - 2015/10/1

N2 - Objective: To investigate the association between muscle perfusion in the peri-articular knee muscles assessed by dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) and symptoms in patients with knee osteoarthritis (KOA). Design: In a cross-sectional setting, muscle perfusion was quantified by DCE-MRI in KOA. Regions of interest (ROI) were drawn around the peri-articular muscles, summed and averaged into one single "Total Muscle Volume" volume of interest (VOI). Symptoms were assessed via the Knee injury and Osteoarthritis Outcome Score (KOOS) (0: worst; 100: best). Results: DCE-MRI and clinical data were analyzed in 94 patients. The typical participant was a woman with a mean age of 65 years, and a body mass index (BMI) of 32 kg/m2. Reduced multiple regression models analyzing the association between KOOS and DCE-MRI perfusion variables of Total Muscle Volume showed a statistically significant association between Nvoxel% and KOOS pain (0.41 (SE 0.14); P = 0.0048). Nvoxel% was defined as the proportion of highly perfused voxels; i.e., the voxels that show an early and rapid increase on the signal intensity vs time curves, reach a plateau state (plateau pattern) and then showing a relatively rapid decline (washout pattern) relative to the total number of voxels within the muscle VOI. Conclusions: More widespread perfusion in the peri-articular knee muscles was associated with less pain in patients with KOA. These results give rise to investigations of the effects of exercise on muscle perfusion and its possible mediating role in the causal pathway between exercise and pain improvements in the conservative management of KOA.

AB - Objective: To investigate the association between muscle perfusion in the peri-articular knee muscles assessed by dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) and symptoms in patients with knee osteoarthritis (KOA). Design: In a cross-sectional setting, muscle perfusion was quantified by DCE-MRI in KOA. Regions of interest (ROI) were drawn around the peri-articular muscles, summed and averaged into one single "Total Muscle Volume" volume of interest (VOI). Symptoms were assessed via the Knee injury and Osteoarthritis Outcome Score (KOOS) (0: worst; 100: best). Results: DCE-MRI and clinical data were analyzed in 94 patients. The typical participant was a woman with a mean age of 65 years, and a body mass index (BMI) of 32 kg/m2. Reduced multiple regression models analyzing the association between KOOS and DCE-MRI perfusion variables of Total Muscle Volume showed a statistically significant association between Nvoxel% and KOOS pain (0.41 (SE 0.14); P = 0.0048). Nvoxel% was defined as the proportion of highly perfused voxels; i.e., the voxels that show an early and rapid increase on the signal intensity vs time curves, reach a plateau state (plateau pattern) and then showing a relatively rapid decline (washout pattern) relative to the total number of voxels within the muscle VOI. Conclusions: More widespread perfusion in the peri-articular knee muscles was associated with less pain in patients with KOA. These results give rise to investigations of the effects of exercise on muscle perfusion and its possible mediating role in the causal pathway between exercise and pain improvements in the conservative management of KOA.

KW - Knee

KW - Magnetic resonance imaging

KW - Muscle perfusion

KW - Osteoarthritis

KW - Symptoms

UR - https://www.scopus.com/pages/publications/84942551653

U2 - 10.1016/j.joca.2015.05.032

DO - 10.1016/j.joca.2015.05.032

M3 - Article

C2 - 26074362

AN - SCOPUS:84942551653

SN - 1063-4584

VL - 23

SP - 1721

EP - 1727

JO - Osteoarthritis and Cartilage

JF - Osteoarthritis and Cartilage

IS - 10

ER -

Associations between muscle perfusion and symptoms in knee osteoarthritis: A cross sectional study

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Keywords

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