ABO blood types and sepsis mortality

Theis S Itenov; Daniel I Sessler; Ashish K Khanna; Sisse R Ostrowski; Pär I Johansson; Christian Erikstrup; Ole B Pedersen; Sofie L Rygård; Lars B Holst; Morten H Bestle; Lars Hein; Anne Lindhardt; Hami Tousi; Mads H Andersen; Thomas Mohr; Jens D Lundgren; Jens-Ulrik Jensen

doi:10.1186/s13613-021-00844-2

ABO blood types and sepsis mortality

Theis S Itenov
, Daniel I Sessler
, Ashish K Khanna
, Sisse R Ostrowski
, Pär I Johansson
, Christian Erikstrup
, Ole B Pedersen
, Sofie L Rygård
, Lars B Holst
, Morten H Bestle
, Lars Hein
, Anne Lindhardt
, Hami Tousi
, Mads H Andersen
, Thomas Mohr
, Jens D Lundgren
, Jens-Ulrik Jensen

Clinical Immunology

Research output: Contribution to journal › Article › Research › peer-review

Abstract

BACKGROUND: We aimed to determine if the ABO blood types carry different risks of 30-day mortality, acute kidney injury (AKI), and endothelial damage in critically ill patients with sepsis. This was a retrospective cohort study of three independent cohorts of critically ill patients from the United States and Scandinavia consisting of adults with septic shock. We compared the 30-day mortality across the blood types within each cohort and pooled the results in a meta-analysis. We also estimated the incidence of AKI and degree of endothelial damage, as measured by blood concentrations of soluble thrombomodulin and syndecan-1.

RESULTS: We included 12,342 patients with severe sepsis. In a pooled analysis blood type B carried a slightly lower risk of 30-day all-cause mortality compared to non-blood type B (adjusted HR 0.88; 95%-CI 0.79-0.98; p = 0.02). There was no difference in the risk of AKI. Soluble thrombomodulin and syndecan-1 concentrations were lower in patients with blood type B and O compared to blood type A, suggesting less endothelial damage.

CONCLUSION: Septic patients with blood type B had less endothelial damage, and a small reduction in mortality. The exposure is, however, unmodifiable.

Original language	English
Pages (from-to)	61
Journal	Annals of Intensive Care
Volume	11
Issue number	1
DOIs	https://doi.org/10.1186/s13613-021-00844-2
Publication status	Published - 20 Apr 2021

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Itenov, T. S., Sessler, D. I., Khanna, A. K., Ostrowski, S. R., Johansson, P. I., Erikstrup, C., Pedersen, O. B., Rygård, S. L., Holst, L. B., Bestle, M. H., Hein, L., Lindhardt, A., Tousi, H., Andersen, M. H., Mohr, T., Lundgren, J. D., & Jensen, J.-U. (2021). ABO blood types and sepsis mortality. Annals of Intensive Care, 11(1), 61. https://doi.org/10.1186/s13613-021-00844-2

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title = "ABO blood types and sepsis mortality",

abstract = "BACKGROUND: We aimed to determine if the ABO blood types carry different risks of 30-day mortality, acute kidney injury (AKI), and endothelial damage in critically ill patients with sepsis. This was a retrospective cohort study of three independent cohorts of critically ill patients from the United States and Scandinavia consisting of adults with septic shock. We compared the 30-day mortality across the blood types within each cohort and pooled the results in a meta-analysis. We also estimated the incidence of AKI and degree of endothelial damage, as measured by blood concentrations of soluble thrombomodulin and syndecan-1.RESULTS: We included 12,342 patients with severe sepsis. In a pooled analysis blood type B carried a slightly lower risk of 30-day all-cause mortality compared to non-blood type B (adjusted HR 0.88; 95\%-CI 0.79-0.98; p = 0.02). There was no difference in the risk of AKI. Soluble thrombomodulin and syndecan-1 concentrations were lower in patients with blood type B and O compared to blood type A, suggesting less endothelial damage.CONCLUSION: Septic patients with blood type B had less endothelial damage, and a small reduction in mortality. The exposure is, however, unmodifiable.",

author = "Itenov, \{Theis S\} and Sessler, \{Daniel I\} and Khanna, \{Ashish K\} and Ostrowski, \{Sisse R\} and Johansson, \{P{\"a}r I\} and Christian Erikstrup and Pedersen, \{Ole B\} and Ryg{\aa}rd, \{Sofie L\} and Holst, \{Lars B\} and Bestle, \{Morten H\} and Lars Hein and Anne Lindhardt and Hami Tousi and Andersen, \{Mads H\} and Thomas Mohr and Lundgren, \{Jens D\} and Jens-Ulrik Jensen",

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doi = "10.1186/s13613-021-00844-2",

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T1 - ABO blood types and sepsis mortality

AU - Itenov, Theis S

AU - Sessler, Daniel I

AU - Khanna, Ashish K

AU - Ostrowski, Sisse R

AU - Johansson, Pär I

AU - Erikstrup, Christian

AU - Pedersen, Ole B

AU - Rygård, Sofie L

AU - Holst, Lars B

AU - Bestle, Morten H

AU - Hein, Lars

AU - Lindhardt, Anne

AU - Tousi, Hami

AU - Andersen, Mads H

AU - Mohr, Thomas

AU - Lundgren, Jens D

AU - Jensen, Jens-Ulrik

PY - 2021/4/20

Y1 - 2021/4/20

N2 - BACKGROUND: We aimed to determine if the ABO blood types carry different risks of 30-day mortality, acute kidney injury (AKI), and endothelial damage in critically ill patients with sepsis. This was a retrospective cohort study of three independent cohorts of critically ill patients from the United States and Scandinavia consisting of adults with septic shock. We compared the 30-day mortality across the blood types within each cohort and pooled the results in a meta-analysis. We also estimated the incidence of AKI and degree of endothelial damage, as measured by blood concentrations of soluble thrombomodulin and syndecan-1.RESULTS: We included 12,342 patients with severe sepsis. In a pooled analysis blood type B carried a slightly lower risk of 30-day all-cause mortality compared to non-blood type B (adjusted HR 0.88; 95%-CI 0.79-0.98; p = 0.02). There was no difference in the risk of AKI. Soluble thrombomodulin and syndecan-1 concentrations were lower in patients with blood type B and O compared to blood type A, suggesting less endothelial damage.CONCLUSION: Septic patients with blood type B had less endothelial damage, and a small reduction in mortality. The exposure is, however, unmodifiable.

AB - BACKGROUND: We aimed to determine if the ABO blood types carry different risks of 30-day mortality, acute kidney injury (AKI), and endothelial damage in critically ill patients with sepsis. This was a retrospective cohort study of three independent cohorts of critically ill patients from the United States and Scandinavia consisting of adults with septic shock. We compared the 30-day mortality across the blood types within each cohort and pooled the results in a meta-analysis. We also estimated the incidence of AKI and degree of endothelial damage, as measured by blood concentrations of soluble thrombomodulin and syndecan-1.RESULTS: We included 12,342 patients with severe sepsis. In a pooled analysis blood type B carried a slightly lower risk of 30-day all-cause mortality compared to non-blood type B (adjusted HR 0.88; 95%-CI 0.79-0.98; p = 0.02). There was no difference in the risk of AKI. Soluble thrombomodulin and syndecan-1 concentrations were lower in patients with blood type B and O compared to blood type A, suggesting less endothelial damage.CONCLUSION: Septic patients with blood type B had less endothelial damage, and a small reduction in mortality. The exposure is, however, unmodifiable.

U2 - 10.1186/s13613-021-00844-2

DO - 10.1186/s13613-021-00844-2

M3 - Article

C2 - 33877463

SN - 2110-5820

VL - 11

SP - 61

JO - Annals of Intensive Care

JF - Annals of Intensive Care

IS - 1

ER -

ABO blood types and sepsis mortality

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