Virusassocieret haemofagocytose-syndrom

Mikkel Faurschou*, Ove Juul Nielsen, Per Boye Hansen, Hans C. Hasselbalch

*Corresponding author af dette arbejde

    Publikation: Bidrag til tidsskriftReviewForskningpeer review


    Virus-associated haemophagocytic syndrome (VAHS) is a rare disease characterized by fever, splenomegaly, cytopenia and histiocytic proliferation with haemophagocytosis in the reticuloendothelial system. The clinical course of VAHS can be dramatic and the prognosis is often poor. The pathogenesis of VAHS is not well understood. Many believe that viral infection provokes an abnormal immune response in predisposed individuals leading to hyperactivation of Th1 helper cells, macrophage proliferation and secretion of large amounts of cytokines. The resultant hypercytokinaemia may be responsible for the clinical and biochemical manifestations of VAHS. In this article the clinical features, presumed pathogenesis, diagnostic criteria and treatment of VAHS are discussed.

    Bidragets oversatte titelVirus-associated haemophagocytic syndrome: Diagnosis and treatment
    Sider (fra-til)6198-6200
    Antal sider3
    TidsskriftUgeskrift for laeger
    Udgave nummer43
    StatusUdgivet - 19 okt. 1998


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