Virus, bacteria and lipopolysaccharide increase basophil cell response to histamine releasing stimulators and calcium: Examination of allergic and normal individuals

P. Clementsen*, S. Norn

*Corresponding author af dette arbejde

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    Abstract

    Histamine release from human basophil leukocytes from allergic patients or controls was induced by specific antigens, anti‐IgE or calcium ionophore A23187, Influenza A virus, S. aureus and lipopolysaccharide from S. typhimurium increased the maximum release of histamine and caused a shift lo the left of the dose‐response curves showing increased cell sensitivity and lowering of the threshold to these stimuli. The mechanism of action was elucidated by examining the mediator release as a function of increasing extracellular concentration of calcium, in these experiments the dose‐response curves were changed by the microorganisms and lipopolysaccharide as before. This indicates that the microorganisms and lipopolysaccharide change the basophil cell response to IgE‐dependent and non‐immunological stimuli by causing a change in the subcellular handling of calcium.

    OriginalsprogEngelsk
    Sider (fra-til)135-141
    Antal sider7
    TidsskriftAllergy
    Vol/bind46
    Udgave nummer2
    DOI
    StatusUdgivet - feb. 1991

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