Virulence Factors for Hemolytic Uremic Syndrome, Denmark

Steen Ethelberg*, Katharina E.P. Olsen, Flemming Scheutz, Charlotte Jensen, Peter Schiellerup, Jørgen Engberg, Andreas Munk Petersen, Bente Olesen, Peter Gerner-Smidt, Kare Mølbak

*Corresponding author af dette arbejde

    Publikation: Bidrag til tidsskriftArtikelForskningpeer review

    Abstract

    We present an analysis of strain and patient factors associated with the development of bloody diarrhea and hemolytic uremic syndrome (HUS) among Shiga toxin-producing Escherichia coli (STEC) patients registered in Denmark in a 6-year period. Of 343 STEC patients, bloody diarrhea developed in 36.4% and HUS in 6.1%. In a multivariate logistic regression model, risk factors for bloody diarrhea were the eae and stx2 genes, O groups 0157 and O103, and increasing age. Risk factors for HUS were presence of the stx2 (odds ratio [OR] 18.9) and eae (OR undefined) genes, being a child, and having bloody diarrhea. O group O157, although associated with HUS in a univariate analysis (OR 4.0), was not associated in the multivariate analysis (OR 1.1). This finding indicates that, rather than the O group, the combined presence of the eae and stx2 genes is an important predictor of HUS.

    OriginalsprogEngelsk
    Sider (fra-til)842-847
    Antal sider6
    TidsskriftEmerging Infectious Diseases
    Vol/bind10
    Udgave nummer5
    DOI
    StatusUdgivet - maj 2004

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