Ventricular repolarization alterations in women with angina pectoris and suspected coronary microvascular dysfunction

Steering Committee of the iPOWER study

Publikation: Bidrag til tidsskriftArtikelForskningpeer review

Abstrakt

Objectives: CMD could be the explanation of angina pectoris with no obstructive CAD and may cause ventricular repolarization changes. We compared T-wave morphology and QTc interval in women with angina pectoris with a control group as well as the associations with CMD. Methods: Women with angina pectoris and no obstructive coronary artery disease (n = 138) and age-matched controls were compared in regard to QTc interval and morphology combination score (MCS) based on T-wave asymmetry, flatness and presence of T-wave notch. CMD was assessed as a coronary flow velocity reserve (CFVR) by transthoracic echocardiography. Results: Women with angina pectoris had significantly longer QTc intervals (429 ± 20 ms) and increased MCS (IQR) (0.73 [0.64–0.80]) compared with the controls (419 ± 20 ms) and (0.63 [(0.53–0.73]), respectively (both p < 0.001). CFVR was associated with longer QTc interval (p = 0.02), but the association was attenuated after multivariable adjustment (p = 0.08). Conclusion: This study suggests that women with angina pectoris have alterations in T-wave morphology as well as longer QTc interval compared with a reference population. CMD might be an explanation.

OriginalsprogEngelsk
Sider (fra-til)15-20
Antal sider6
TidsskriftJournal of Electrocardiology
Vol/bind51
Udgave nummer1
DOI
StatusUdgivet - jan. 2018

Fingeraftryk Udforsk hvilke forskningsemner 'Ventricular repolarization alterations in women with angina pectoris and suspected coronary microvascular dysfunction' indeholder.

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