Use of an enhanced gradient system for diffusion MR imaging with motion-artifact reduction

S. Brockstedt*, C. Thomsen, R. Wirestam, J. de Poorter, C. de Wagter, L. G. Salford, S. Holtås, F. Ståhlberg

*Corresponding author af dette arbejde

    Publikation: Bidrag til tidsskriftArtikelForskningpeer review


    A spin-echo diffusion-sensitized pulse sequence using high gradients (23 mT/m) is introduced. In order to minimize motion artefacts, velocity-compensating gradients, ECG-triggering and post-processing with phase correction and raw data averaging using navigator echoes was performed. The in vitro ratio of diffusion coefficients for water and acetone was determined and the water self-diffusion coefficient at different temperatures was evaluated. The pulse sequence was tested in 7 healthy volunteers and in 2 tumour patients with astrocytomas of grades I—II and III—IV. Both single-slice and multi-slice techniques were used. The incorporation of phase correction clearly improved the quality of both diffusion-encoded images and the calculated diffusion maps. Mean values of the diffusion coefficients in vivo were for CSF 2.66×10−9 m2/s and for white and grey matter 0.69×10−9 m2/s and 0.87×10−9 m2/s, respectively. Velocity-compensating gradients in combination with a high gradient strength were shown to be useful for in vivo diffusion MR imaging.

    Sider (fra-til)662-670
    Antal sider9
    TidsskriftActa Radiologica
    Udgave nummer4-6
    StatusUdgivet - jul. 1995


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