Use of acid-suppressive therapy before anti-reflux surgery in 2922 patients: A nationwide register-based study in Denmark

A. Lødrup, A. Pottegård, J. Hallas, P. Bytzer

Publikation: Bidrag til tidsskriftArtikelForskningpeer review

Abstrakt

Background Guidelines recommend that patients with gastro-oesophageal reflux disease are adequately treated with acid-suppressive therapy before undergoing anti-reflux surgery. Little is known of the use of acid-suppressive drugs before anti-reflux surgery. Aim To determine the use of proton pump inhibitors and H2-receptor antagonists in the year before anti-reflux surgery. Methods A nationwide retrospective study of all patients aged ≥18 undergoing first-time anti-reflux surgery in Denmark during 2000-2012 using data from three different sources: the Danish National Register of Patients, the Danish National Prescription Register, and the Danish Person Register. Results The study population thus included 2922 patients (median age: 48 years, 55.7% male). The annual proportion of patients redeeming ≥180 DDD of acid-suppressive therapy increased from 17.0% 5 years before anti-reflux surgery to 64.9% 1 year before. The probability for inadequate dosing 1 year before surgery (<180 DDD) was significantly increased for younger patients, patients operated in the period 2000-2003, patients who had not undergone pre-surgical manometry, pH- or impedance monitoring, and patients who had not redeemed prescriptions on NSAID or anti-platelet drugs. Conclusion Compliance with medical therapy should be evaluated thoroughly before planning anti-reflux surgery, as a high proportion of patients receive inadequate dosing of acid-suppressive therapy prior to the operation.

OriginalsprogEngelsk
Sider (fra-til)84-90
Antal sider7
TidsskriftAlimentary Pharmacology and Therapeutics
Vol/bind42
Udgave nummer1
DOI
StatusUdgivet - 1 jul. 2015

Fingeraftryk Udforsk hvilke forskningsemner 'Use of acid-suppressive therapy before anti-reflux surgery in 2922 patients: A nationwide register-based study in Denmark' indeholder.

Citationsformater