Update on Nephrogenic Systemic Fibrosis

Henrik S. Thomsen*, Peter Marckmann, Vibeke B. Logager

*Corresponding author af dette arbejde

    Publikation: Bidrag til tidsskriftReviewForskningpeer review


    Gadolinium-based contrast agents were for many years considered safe, but this is no longer the case. The least stable agents may trigger the development of nephrogenic systemic fibrosis (NSF), a generalized fibrotic disorder, in renal failure patients. The use of gadodiamide and gadopentetate dimeglumine is now contraindicated in Europe and Japan in patients who have a glomerular filtration rate less than 30 mL/min/1.73 m2, including those on dialysis. The fear of NSF, however, should not lead to an enhanced MR imaging examination being denied when there is a good clinical indication to give a gadolinium-based contrast agent.

    Sider (fra-til)551-560
    Antal sider10
    TidsskriftMagnetic Resonance Imaging Clinics of North America
    Udgave nummer4
    StatusUdgivet - 1 nov. 2008


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