Background. Interferon-γ has been suggested as causal therapy in both hyper-IgE syndrome and severe atopic dermatitis. Aim. To investigate the therapeutic effect of short-term, low-dose interferon-γ both as monotherapy and in combination with topical treatment, in a patient with a variant of the hyper-IgE syndrome. Method. Interferon-γ was administered subcutaneously (50 μg/m2 x 3 d/w) for 4 weeks. Three regions were studied: hands, flank and feet. The hands were treated with betamethasone-17-valerate-cream and the feet with mupirocin ointment, while the flank was treated only with a moisturizer. Results. All regions showed significant reductions of the clinical scores (0.0001 < P < 0.0280), but hands and feet showed significantly greater reduction than flank (P < 0.004). Conclusions. The results suggest that short-term, low-dose interferon-γ treatment is a potentially useful therapy in hyper-IgE syndrome dermatitis when used in combination with topical mupirocin or a steroid.
|Tidsskrift||Journal of the European Academy of Dermatology and Venereology|
|Status||Udgivet - 1 jan. 1996|