Theoretical considerations on the use of diffusion weighted MRI for detection of in vivo brain electroporation

Faisal Mahmood*, Rasmus H. Hansen, Julie Gehl

*Corresponding author af dette arbejde

    Publikation: Bidrag til bog/antologi/rapportKonferencebidragForskningpeer review

    Abstrakt

    Electroporation (EP), the permeabilization of cellular membrane by externally applied voltage pulses, has shown its potential as treatment for cancer when combined with chemotherapeutic agents (electrochemotherapy) and genes (gene electrotransfer). Imaging biomarkers for EP based treatments are therefore needed for monitoring the response both during medical procedures and follow-up. In this paper we focus on diffusion weighted magnetic resonance imaging (DW-MRI) as a non-invasive and quantitative tool for detection of electroporation of brain tissue. We discuss the impact of issues such as joule heating, tissue perfusion, cell morphology on the DW-MRI measurement. We conclude that DW-MRI may potentially be used for direct detection of induced membrane permeabilization, but a number of fundamental challenges need to be dealt with.

    OriginalsprogEngelsk
    Titel6th European Conference of the International Federation for Medical and Biological Engineering - MBEC 2014
    RedaktørerIgor Lackovic, Darko Vasic
    ForlagSpringer Verlag
    Sider837-840
    Antal sider4
    ISBN (Elektronisk)9783319111278
    DOI
    StatusUdgivet - 1 jan. 2015
    Begivenhed6th European Conference of the International Federation for Medical and Biological Engineering, MBEC 2014 - Dubrovnik, Kroatien
    Varighed: 7 sep. 201411 sep. 2014

    Publikationsserier

    NavnIFMBE Proceedings
    Vol/bind45
    ISSN (Trykt)1680-0737

    Konference

    Konference6th European Conference of the International Federation for Medical and Biological Engineering, MBEC 2014
    Land/OmrådeKroatien
    ByDubrovnik
    Periode7/09/1411/09/14

    Fingeraftryk

    Udforsk hvilke forskningsemner 'Theoretical considerations on the use of diffusion weighted MRI for detection of in vivo brain electroporation' indeholder.

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