TY - JOUR
T1 - The subcortical belly of sleep
T2 - New possibilities in neuromodulation of basal ganglia?
AU - Hasegawa, Harutomo
AU - Selway, Richard
AU - Gnoni, Valentina
AU - Beniczky, Sandor
AU - Williams, Steve C R
AU - Kryger, Meir
AU - Ferini-Strambi, Luigi
AU - Goadsby, Peter
AU - Leschziner, Guy D
AU - Ashkan, Keyoumars
AU - Rosenzweig, Ivana
N1 - Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.
PY - 2020/8
Y1 - 2020/8
N2 - Early studies posited a relationship between sleep and the basal ganglia, but this relationship has received little attention recently. It is timely to revisit this relationship, given new insights into the functional anatomy of the basal ganglia and the physiology of sleep, which has been made possible by modern techniques such as chemogenetic and optogenetic mapping of neural circuits in rodents and intracranial recording, functional imaging, and a better understanding of human sleep disorders. We discuss the functional anatomy of the basal ganglia, and review evidence implicating their role in sleep. Whilst these studies are in their infancy, we suggest that the basal ganglia may play an integral role in the sleep-wake cycle, specifically by contributing to a thalamo-cortical-basal ganglia oscillatory network in slow-wave sleep which facilitates neural plasticity, and an active state during REM sleep which enables the enactment of cognitive and emotional networks. A better understanding of sleep mechanisms may pave the way for more effective neuromodulation strategies for sleep and basal ganglia disorders.
AB - Early studies posited a relationship between sleep and the basal ganglia, but this relationship has received little attention recently. It is timely to revisit this relationship, given new insights into the functional anatomy of the basal ganglia and the physiology of sleep, which has been made possible by modern techniques such as chemogenetic and optogenetic mapping of neural circuits in rodents and intracranial recording, functional imaging, and a better understanding of human sleep disorders. We discuss the functional anatomy of the basal ganglia, and review evidence implicating their role in sleep. Whilst these studies are in their infancy, we suggest that the basal ganglia may play an integral role in the sleep-wake cycle, specifically by contributing to a thalamo-cortical-basal ganglia oscillatory network in slow-wave sleep which facilitates neural plasticity, and an active state during REM sleep which enables the enactment of cognitive and emotional networks. A better understanding of sleep mechanisms may pave the way for more effective neuromodulation strategies for sleep and basal ganglia disorders.
KW - Basal ganglia
KW - Sleep
KW - Neuromodulation
KW - Memory
U2 - 10.1016/j.smrv.2020.101317
DO - 10.1016/j.smrv.2020.101317
M3 - Review
C2 - 32446196
VL - 52
SP - 101317
JO - Sleep Medicine Reviews
JF - Sleep Medicine Reviews
SN - 1087-0792
ER -