TY - JOUR
T1 - The Prospective Studies of Atherosclerosis (Proof-ATHERO) Consortium
T2 - Design and Rationale
AU - Proof-ATHERO Study Group
AU - Tschiderer, Lena
AU - Seekircher, Lisa
AU - Klingenschmid, Gerhard
AU - Izzo, Raffaele
AU - Baldassarre, Damiano
AU - Iglseder, Bernhard
AU - Calabresi, Laura
AU - Liu, Jing
AU - Price, Jackie F
AU - Bae, Jang-Ho
AU - Brouwers, Frank P
AU - de Groot, Eric
AU - Schmidt, Caroline
AU - Bergström, Göran
AU - Aşçi, Gülay
AU - Gresele, Paolo
AU - Okazaki, Shuhei
AU - Kapellas, Kostas
AU - Landecho, Manuel F
AU - Sattar, Naveed
AU - Agewall, Stefan
AU - Zou, Zhi-Yong
AU - Byrne, Christopher D
AU - Nanayakkara, Prabath W B
AU - Papagianni, Aikaterini
AU - Witham, Miles D
AU - Bernal, Enrique
AU - Ekart, Robert
AU - van Agtmael, Michiel A
AU - Neves, Mario F
AU - Sato, Eiichi
AU - Ezhov, Marat
AU - Walters, Matthew
AU - Olsen, Michael H
AU - Stolić, Radojica
AU - Zozulińska-Ziółkiewicz, Dorota A
AU - Hanefeld, Markolf
AU - Staub, Daniel
AU - Nagai, Michiaki
AU - Nieuwkerk, Pythia T
AU - Huisman, Menno V
AU - Kato, Akihiko
AU - Honda, Hirokazu
AU - Parraga, Grace
AU - Magliano, Dianna
AU - Gabriel, Rafael
AU - Rundek, Tatjana
AU - Espeland, Mark A
AU - Kiechl, Stefan
AU - Willeit, Johann
N1 - © 2020 S. Karger AG, Basel.
PY - 2020
Y1 - 2020
N2 - Atherosclerosis - the pathophysiological mechanism shared by most cardiovascular diseases - can be directly or indirectly assessed by a variety of clinical tests including measurement of carotid intima-media thickness, carotid plaque, -ankle-brachial index, pulse wave velocity, and coronary -artery calcium. The Prospective Studies of Atherosclerosis -(Proof-ATHERO) consortium (https://clinicalepi.i-med.ac.at/research/proof-athero/) collates de-identified individual-participant data of studies with information on atherosclerosis measures, risk factors for cardiovascular disease, and incidence of cardiovascular diseases. It currently comprises 74 studies that involve 106,846 participants from 25 countries and over 40 cities. In summary, 21 studies recruited participants from the general population (n = 67,784), 16 from high-risk populations (n = 22,677), and 37 as part of clinical trials (n = 16,385). Baseline years of contributing studies range from April 1980 to July 2014; the latest follow-up was until June 2019. Mean age at baseline was 59 years (standard deviation: 10) and 50% were female. Over a total of 830,619 person-years of follow-up, 17,270 incident cardiovascular events (including coronary heart disease and stroke) and 13,270 deaths were recorded, corresponding to cumulative incidences of 2.1% and 1.6% per annum, respectively. The consortium is coordinated by the Clinical Epidemiology Team at the Medical University of Innsbruck, Austria. Contributing studies undergo a detailed data cleaning and harmonisation procedure before being incorporated in the Proof-ATHERO central database. Statistical analyses are being conducted according to pre-defined analysis plans and use established methods for individual-participant data meta-analysis. Capitalising on its large sample size, the multi-institutional collaborative Proof-ATHERO consortium aims to better characterise, understand, and predict the development of atherosclerosis and its clinical consequences.
AB - Atherosclerosis - the pathophysiological mechanism shared by most cardiovascular diseases - can be directly or indirectly assessed by a variety of clinical tests including measurement of carotid intima-media thickness, carotid plaque, -ankle-brachial index, pulse wave velocity, and coronary -artery calcium. The Prospective Studies of Atherosclerosis -(Proof-ATHERO) consortium (https://clinicalepi.i-med.ac.at/research/proof-athero/) collates de-identified individual-participant data of studies with information on atherosclerosis measures, risk factors for cardiovascular disease, and incidence of cardiovascular diseases. It currently comprises 74 studies that involve 106,846 participants from 25 countries and over 40 cities. In summary, 21 studies recruited participants from the general population (n = 67,784), 16 from high-risk populations (n = 22,677), and 37 as part of clinical trials (n = 16,385). Baseline years of contributing studies range from April 1980 to July 2014; the latest follow-up was until June 2019. Mean age at baseline was 59 years (standard deviation: 10) and 50% were female. Over a total of 830,619 person-years of follow-up, 17,270 incident cardiovascular events (including coronary heart disease and stroke) and 13,270 deaths were recorded, corresponding to cumulative incidences of 2.1% and 1.6% per annum, respectively. The consortium is coordinated by the Clinical Epidemiology Team at the Medical University of Innsbruck, Austria. Contributing studies undergo a detailed data cleaning and harmonisation procedure before being incorporated in the Proof-ATHERO central database. Statistical analyses are being conducted according to pre-defined analysis plans and use established methods for individual-participant data meta-analysis. Capitalising on its large sample size, the multi-institutional collaborative Proof-ATHERO consortium aims to better characterise, understand, and predict the development of atherosclerosis and its clinical consequences.
KW - Prospective studies
KW - Consortium
KW - Individual-participant data
KW - Atherosclerosis
KW - Repeat measurements
KW - Cardiovascular disease
U2 - 10.1159/000508498
DO - 10.1159/000508498
M3 - Protocol
C2 - 32610336
SN - 0304-324X
VL - 66
SP - 447
EP - 459
JO - Gerontology
JF - Gerontology
IS - 5
ER -