The influence of sex hormones on UVB induced erythema in man

Gregor B.E. Jemec; Michael Heidenheim

doi:10.1016/0923-1811(94)00361-H

The influence of sex hormones on UVB induced erythema in man

Gregor B.E. Jemec^*, Michael Heidenheim

^*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift › Artikel › Forskning › peer review

Abstract

Clinical and experimental evidence suggests that sex hormones can modify the inflammatory response in a number of diseases. In a pilot study the influence of sex hormones on UV-induced inflammation, testing was done with oestradiol-17β, testosterone and progesterone, as a double-blind vehicle-controlled study in 47 healthy volunteers. Inflammation was graded using laser-doppler velocimetry. Oestradiol (5 mg/100 g) was found to increase the inflammatory response significantly when compared with placebo or testosterone treated areas (P < 0.03). These findings support previous experimental and epidemiological observations of an increased inflammation following oestrogenic stimulation, and suggest that non-lymphocyte-mediated mechanisms may be involved as well.

Originalsprog	Engelsk
Sider (fra-til)	221-224
Antal sider	4
Tidsskrift	Journal of Dermatological Science
Vol/bind	9
Udgave nummer	3
DOI	https://doi.org/10.1016/0923-1811(94)00361-H
Status	Udgivet - maj 1995

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title = "The influence of sex hormones on UVB induced erythema in man",

abstract = "Clinical and experimental evidence suggests that sex hormones can modify the inflammatory response in a number of diseases. In a pilot study the influence of sex hormones on UV-induced inflammation, testing was done with oestradiol-17β, testosterone and progesterone, as a double-blind vehicle-controlled study in 47 healthy volunteers. Inflammation was graded using laser-doppler velocimetry. Oestradiol (5 mg/100 g) was found to increase the inflammatory response significantly when compared with placebo or testosterone treated areas (P < 0.03). These findings support previous experimental and epidemiological observations of an increased inflammation following oestrogenic stimulation, and suggest that non-lymphocyte-mediated mechanisms may be involved as well.",

keywords = "Inflammation, Oestrogen, Sex hormones, UVB-irradiation",

author = "Jemec, {Gregor B.E.} and Michael Heidenheim",

year = "1995",

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T1 - The influence of sex hormones on UVB induced erythema in man

AU - Jemec, Gregor B.E.

AU - Heidenheim, Michael

PY - 1995/5

Y1 - 1995/5

N2 - Clinical and experimental evidence suggests that sex hormones can modify the inflammatory response in a number of diseases. In a pilot study the influence of sex hormones on UV-induced inflammation, testing was done with oestradiol-17β, testosterone and progesterone, as a double-blind vehicle-controlled study in 47 healthy volunteers. Inflammation was graded using laser-doppler velocimetry. Oestradiol (5 mg/100 g) was found to increase the inflammatory response significantly when compared with placebo or testosterone treated areas (P < 0.03). These findings support previous experimental and epidemiological observations of an increased inflammation following oestrogenic stimulation, and suggest that non-lymphocyte-mediated mechanisms may be involved as well.

AB - Clinical and experimental evidence suggests that sex hormones can modify the inflammatory response in a number of diseases. In a pilot study the influence of sex hormones on UV-induced inflammation, testing was done with oestradiol-17β, testosterone and progesterone, as a double-blind vehicle-controlled study in 47 healthy volunteers. Inflammation was graded using laser-doppler velocimetry. Oestradiol (5 mg/100 g) was found to increase the inflammatory response significantly when compared with placebo or testosterone treated areas (P < 0.03). These findings support previous experimental and epidemiological observations of an increased inflammation following oestrogenic stimulation, and suggest that non-lymphocyte-mediated mechanisms may be involved as well.

KW - Inflammation

KW - Oestrogen

KW - Sex hormones

KW - UVB-irradiation

UR - http://www.scopus.com/inward/record.url?scp=0028964987&partnerID=8YFLogxK

U2 - 10.1016/0923-1811(94)00361-H

DO - 10.1016/0923-1811(94)00361-H

M3 - Article

C2 - 8664221

AN - SCOPUS:0028964987

SN - 0923-1811

VL - 9

SP - 221

EP - 224

JO - Journal of Dermatological Science

JF - Journal of Dermatological Science

IS - 3

ER -

The influence of sex hormones on UVB induced erythema in man

Abstract

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