The importance of Notch signaling in peripheral T-cell lymphomas

Maria Rorbæk Kamstrup, Edyta Biskup, Lise Mette Rahbek Gjerdrum, Elizabeth Ralfkiaer, Omid Niazi, Robert Gniadecki

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    Abstrakt

    Peripheral T-cell lymphomas (PTLs) represent an area of high medical need. Previously, we demonstrated high expression of Notch, a known oncogene, in primary cutaneous anaplastic large cell lymphoma (ALCL). In this study, we performed immunohistochemical staining for Notch1 in lymph nodes from PTL not otherwise specifi ed (PTL-NOS) and systemic ALCL (ALK + and ALK - ) and report a similar distribution among the three subgroups: Negative, moderate and strong expression was, respectively, 18%, 27% and 55% for PTL-NOS (33 cases), 20%, 0% and 80% for ALCL ALK - (10 cases) and 45%, 22% and 33% for ALCL ALK - (nine cases) ( p <0.05). In the ALK - ALCL cell line, Karpas-299, pharmacological inhibition of Notch with γ -secretase inhibitor (GSI) I was far more potent than with GSI IX, XX and XXI with regard to cell viability and apoptosis. In conclusion, PTL tumor cells have prominent Notch1 expression and treatment with Notch inhibitors has cytotoxic eff ects

    OriginalsprogEngelsk
    Sider (fra-til)639-644
    Antal sider6
    TidsskriftLeukemia and Lymphoma
    Vol/bind55
    Udgave nummer3
    DOI
    StatusUdgivet - 1 mar. 2014

    Fingeraftryk Udforsk hvilke forskningsemner 'The importance of Notch signaling in peripheral T-cell lymphomas' indeholder.

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