The impact of interferon-alpha2 on HLA genes in patients with polycythemia vera and related neoplasms

Vibe Skov, Caroline Hasselbalch Riley, Mads Thomassen, Lasse Kjær, Thomas Stauffer Larsen, Ole Weis Bjerrum, Torben A. Kruse, Hans Carl Hasselbalch

Publikation: Bidrag til tidsskriftArtikelForskningpeer review

Abstrakt

Gene expression profiling in Philadelphia-negative chronic myeloproliferative neoplasms (MPNs) have unraveled significant deregulation of several immune and inflammation genes of potential importance for clonal evolution. Other mechanisms might be downregulation of major histocompatibility class I and II genes used by tumor cells to escape antitumor T-cell-mediated immune responses. Several genes encoding human leukocyte antigen (HLA) class I and II molecules have been shown to be significantly downregulated. Upregulation of HLA genes is considered one of the mechanisms of action of interferon (IFN)-alpha2, but regulation of these genes during IFN-alpha2 treatment in MPNs has never been studied. Our findings show a significant upregulation of several HLA genes of importance for tumor immune surveillance by IFN-alpha2 treatment in MPNs. This mechanism might enhance the cytotoxic potential of immune cells against MPNs and explain the induction of minimal residual disease by IFN-alpha2 treatment in these patients.

OriginalsprogEngelsk
Sider (fra-til)1914-1921
Antal sider8
TidsskriftLeukemia and Lymphoma
Vol/bind58
Udgave nummer8
DOI
StatusUdgivet - 3 aug. 2017

Fingeraftryk Udforsk hvilke forskningsemner 'The impact of interferon-alpha2 on HLA genes in patients with polycythemia vera and related neoplasms' indeholder.

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