The impact of CCR5-δ32 deletion on C-reactive protein levels and cardiovascular disease: Results from the Danish Blood Donor Study

Khoa M. Dinh; Ole B. Pedersen; Mikkel S. Petersen; Erik Sørensen; Cecilie J. Sørensen; Kathrine A. Kaspersen; Margit H. Larsen; Bjarne Møller; Henrik Hjalgrim; Henrik Ullum; Christian Erikstrup

doi:10.1016/j.atherosclerosis.2015.07.031

The impact of CCR5-δ32 deletion on C-reactive protein levels and cardiovascular disease: Results from the Danish Blood Donor Study

Khoa M. Dinh, Ole B. Pedersen, Mikkel S. Petersen, Erik Sørensen, Cecilie J. Sørensen, Kathrine A. Kaspersen, Margit H. Larsen, Bjarne Møller, Henrik Hjalgrim, Henrik Ullum, Christian Erikstrup

Klinisk Immunologisk Afdeling

Publikation: Bidrag til tidsskrift › Artikel › Forskning › peer review

Abstrakt

Background and purpose: The C-C chemokine receptor 5-δ32 deletion (CCR5-δ32) has been associated with lower levels of C-reactive protein (CRP), but the effect on cardiovascular diseases is uncertain. This study addresses the impact of CCR5-δ32 on the risk of low-grade inflammation and hospitalization with cardiovascular diseases in a large cohort of blood donors. Methods: Genotyping of 15,206 healthy participants from The Danish Blood Donor Study for CCR5-δ32 was performed and combined with CRP measurements and questionnaire data. Cardiovascular disease diagnoses were identified by ICD-10 codes in the Danish National Patient Registry. Results: CCR5-δ32-carriers had a higher risk of hospitalization for cardiovascular diseases when compared with wild-type homozygotes (hazard ratio=1.35, 95%-confidence interval: 1.00-1.87). CRP levels were unaffected by the CCR5-δ32 deletion. Conclusion: In this cohort, carriers of the CCR5-δ32 deletion had normal CRP levels but a borderline significant increased risk of cardiovascular diseases.

Originalsprog	Engelsk
Sider (fra-til)	222-225
Antal sider	4
Tidsskrift	Atherosclerosis
Vol/bind	242
Udgave nummer	1
DOI	https://doi.org/10.1016/j.atherosclerosis.2015.07.031
Status	Udgivet - 1 aug. 2015

Adgang til dokumentet

10.1016/j.atherosclerosis.2015.07.031

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http://www.scopus.com/inward/record.url?scp=84938084014&partnerID=8YFLogxK

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Citationsformater

Dinh, K. M., Pedersen, O. B., Petersen, M. S., Sørensen, E., Sørensen, C. J., Kaspersen, K. A., Larsen, M. H., Møller, B., Hjalgrim, H., Ullum, H., & Erikstrup, C. (2015). The impact of CCR5-δ32 deletion on C-reactive protein levels and cardiovascular disease: Results from the Danish Blood Donor Study. Atherosclerosis, 242(1), 222-225. https://doi.org/10.1016/j.atherosclerosis.2015.07.031

Dinh, Khoa M. ; Pedersen, Ole B. ; Petersen, Mikkel S. ; Sørensen, Erik ; Sørensen, Cecilie J. ; Kaspersen, Kathrine A. ; Larsen, Margit H. ; Møller, Bjarne ; Hjalgrim, Henrik ; Ullum, Henrik ; Erikstrup, Christian. / The impact of CCR5-δ32 deletion on C-reactive protein levels and cardiovascular disease : Results from the Danish Blood Donor Study. I: Atherosclerosis. 2015 ; Bind 242, Nr. 1. s. 222-225.

@article{a1c9c14ce4ce41218ed4088c3c4c7eee,

title = "The impact of CCR5-δ32 deletion on C-reactive protein levels and cardiovascular disease: Results from the Danish Blood Donor Study",

abstract = "Background and purpose: The C-C chemokine receptor 5-δ32 deletion (CCR5-δ32) has been associated with lower levels of C-reactive protein (CRP), but the effect on cardiovascular diseases is uncertain. This study addresses the impact of CCR5-δ32 on the risk of low-grade inflammation and hospitalization with cardiovascular diseases in a large cohort of blood donors. Methods: Genotyping of 15,206 healthy participants from The Danish Blood Donor Study for CCR5-δ32 was performed and combined with CRP measurements and questionnaire data. Cardiovascular disease diagnoses were identified by ICD-10 codes in the Danish National Patient Registry. Results: CCR5-δ32-carriers had a higher risk of hospitalization for cardiovascular diseases when compared with wild-type homozygotes (hazard ratio=1.35, 95%-confidence interval: 1.00-1.87). CRP levels were unaffected by the CCR5-δ32 deletion. Conclusion: In this cohort, carriers of the CCR5-δ32 deletion had normal CRP levels but a borderline significant increased risk of cardiovascular diseases.",

keywords = "Atherosclerosis, Cardiovascular diseases, CCR5 receptor, Epidemiology, Genetics, Inflammation",

author = "Dinh, {Khoa M.} and Pedersen, {Ole B.} and Petersen, {Mikkel S.} and Erik S{\o}rensen and S{\o}rensen, {Cecilie J.} and Kaspersen, {Kathrine A.} and Larsen, {Margit H.} and Bjarne M{\o}ller and Henrik Hjalgrim and Henrik Ullum and Christian Erikstrup",

year = "2015",

month = aug,

day = "1",

doi = "10.1016/j.atherosclerosis.2015.07.031",

language = "English",

volume = "242",

pages = "222--225",

journal = "Atherosclerosis",

issn = "0021-9150",

publisher = "Elsevier Ireland Ltd",

number = "1",

}

Dinh, KM, Pedersen, OB, Petersen, MS, Sørensen, E, Sørensen, CJ, Kaspersen, KA, Larsen, MH, Møller, B, Hjalgrim, H, Ullum, H & Erikstrup, C 2015, 'The impact of CCR5-δ32 deletion on C-reactive protein levels and cardiovascular disease: Results from the Danish Blood Donor Study', Atherosclerosis, bind 242, nr. 1, s. 222-225. https://doi.org/10.1016/j.atherosclerosis.2015.07.031

The impact of CCR5-δ32 deletion on C-reactive protein levels and cardiovascular disease : Results from the Danish Blood Donor Study. / Dinh, Khoa M.; Pedersen, Ole B.; Petersen, Mikkel S.; Sørensen, Erik; Sørensen, Cecilie J.; Kaspersen, Kathrine A.; Larsen, Margit H.; Møller, Bjarne; Hjalgrim, Henrik; Ullum, Henrik; Erikstrup, Christian.

I: Atherosclerosis, Bind 242, Nr. 1, 01.08.2015, s. 222-225.

Publikation: Bidrag til tidsskrift › Artikel › Forskning › peer review

TY - JOUR

T1 - The impact of CCR5-δ32 deletion on C-reactive protein levels and cardiovascular disease

T2 - Results from the Danish Blood Donor Study

AU - Dinh, Khoa M.

AU - Pedersen, Ole B.

AU - Petersen, Mikkel S.

AU - Sørensen, Erik

AU - Sørensen, Cecilie J.

AU - Kaspersen, Kathrine A.

AU - Larsen, Margit H.

AU - Møller, Bjarne

AU - Hjalgrim, Henrik

AU - Ullum, Henrik

AU - Erikstrup, Christian

PY - 2015/8/1

Y1 - 2015/8/1

N2 - Background and purpose: The C-C chemokine receptor 5-δ32 deletion (CCR5-δ32) has been associated with lower levels of C-reactive protein (CRP), but the effect on cardiovascular diseases is uncertain. This study addresses the impact of CCR5-δ32 on the risk of low-grade inflammation and hospitalization with cardiovascular diseases in a large cohort of blood donors. Methods: Genotyping of 15,206 healthy participants from The Danish Blood Donor Study for CCR5-δ32 was performed and combined with CRP measurements and questionnaire data. Cardiovascular disease diagnoses were identified by ICD-10 codes in the Danish National Patient Registry. Results: CCR5-δ32-carriers had a higher risk of hospitalization for cardiovascular diseases when compared with wild-type homozygotes (hazard ratio=1.35, 95%-confidence interval: 1.00-1.87). CRP levels were unaffected by the CCR5-δ32 deletion. Conclusion: In this cohort, carriers of the CCR5-δ32 deletion had normal CRP levels but a borderline significant increased risk of cardiovascular diseases.

AB - Background and purpose: The C-C chemokine receptor 5-δ32 deletion (CCR5-δ32) has been associated with lower levels of C-reactive protein (CRP), but the effect on cardiovascular diseases is uncertain. This study addresses the impact of CCR5-δ32 on the risk of low-grade inflammation and hospitalization with cardiovascular diseases in a large cohort of blood donors. Methods: Genotyping of 15,206 healthy participants from The Danish Blood Donor Study for CCR5-δ32 was performed and combined with CRP measurements and questionnaire data. Cardiovascular disease diagnoses were identified by ICD-10 codes in the Danish National Patient Registry. Results: CCR5-δ32-carriers had a higher risk of hospitalization for cardiovascular diseases when compared with wild-type homozygotes (hazard ratio=1.35, 95%-confidence interval: 1.00-1.87). CRP levels were unaffected by the CCR5-δ32 deletion. Conclusion: In this cohort, carriers of the CCR5-δ32 deletion had normal CRP levels but a borderline significant increased risk of cardiovascular diseases.

KW - Atherosclerosis

KW - Cardiovascular diseases

KW - CCR5 receptor

KW - Epidemiology

KW - Genetics

KW - Inflammation

UR - http://www.scopus.com/inward/record.url?scp=84938084014&partnerID=8YFLogxK

U2 - 10.1016/j.atherosclerosis.2015.07.031

DO - 10.1016/j.atherosclerosis.2015.07.031

M3 - Article

C2 - 26222902

AN - SCOPUS:84938084014

VL - 242

SP - 222

EP - 225

JO - Atherosclerosis

JF - Atherosclerosis

SN - 0021-9150

IS - 1

ER -