The impact of CCR5-δ32 deletion on C-reactive protein levels and cardiovascular disease: Results from the Danish Blood Donor Study

Khoa M. Dinh, Ole B. Pedersen, Mikkel S. Petersen, Erik Sørensen, Cecilie J. Sørensen, Kathrine A. Kaspersen, Margit H. Larsen, Bjarne Møller, Henrik Hjalgrim, Henrik Ullum, Christian Erikstrup

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Abstrakt

Background and purpose: The C-C chemokine receptor 5-δ32 deletion (CCR5-δ32) has been associated with lower levels of C-reactive protein (CRP), but the effect on cardiovascular diseases is uncertain. This study addresses the impact of CCR5-δ32 on the risk of low-grade inflammation and hospitalization with cardiovascular diseases in a large cohort of blood donors. Methods: Genotyping of 15,206 healthy participants from The Danish Blood Donor Study for CCR5-δ32 was performed and combined with CRP measurements and questionnaire data. Cardiovascular disease diagnoses were identified by ICD-10 codes in the Danish National Patient Registry. Results: CCR5-δ32-carriers had a higher risk of hospitalization for cardiovascular diseases when compared with wild-type homozygotes (hazard ratio=1.35, 95%-confidence interval: 1.00-1.87). CRP levels were unaffected by the CCR5-δ32 deletion. Conclusion: In this cohort, carriers of the CCR5-δ32 deletion had normal CRP levels but a borderline significant increased risk of cardiovascular diseases.

OriginalsprogEngelsk
Sider (fra-til)222-225
Antal sider4
TidsskriftAtherosclerosis
Vol/bind242
Udgave nummer1
DOI
StatusUdgivet - 1 aug. 2015

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