The impact of CCR5-δ32 deletion on C-reactive protein levels and cardiovascular disease: Results from the Danish Blood Donor Study

Khoa M. Dinh*, Ole B. Pedersen, Mikkel S. Petersen, Erik Sørensen, Cecilie J. Sørensen, Kathrine A. Kaspersen, Margit H. Larsen, Bjarne Møller, Henrik Hjalgrim, Henrik Ullum, Christian Erikstrup

*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskriftArtikelForskningpeer review

Abstract

Background and purpose: The C-C chemokine receptor 5-δ32 deletion (CCR5-δ32) has been associated with lower levels of C-reactive protein (CRP), but the effect on cardiovascular diseases is uncertain. This study addresses the impact of CCR5-δ32 on the risk of low-grade inflammation and hospitalization with cardiovascular diseases in a large cohort of blood donors. Methods: Genotyping of 15,206 healthy participants from The Danish Blood Donor Study for CCR5-δ32 was performed and combined with CRP measurements and questionnaire data. Cardiovascular disease diagnoses were identified by ICD-10 codes in the Danish National Patient Registry. Results: CCR5-δ32-carriers had a higher risk of hospitalization for cardiovascular diseases when compared with wild-type homozygotes (hazard ratio=1.35, 95%-confidence interval: 1.00-1.87). CRP levels were unaffected by the CCR5-δ32 deletion. Conclusion: In this cohort, carriers of the CCR5-δ32 deletion had normal CRP levels but a borderline significant increased risk of cardiovascular diseases.

OriginalsprogEngelsk
Sider (fra-til)222-225
Antal sider4
TidsskriftAtherosclerosis
Vol/bind242
Udgave nummer1
DOI
StatusUdgivet - 1 aug. 2015

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