The effect of melatonin on sleep quality after laparoscopic cholecystectomy: A randomized, placebo-controlled trial

Ismail Gögenur, Bülent Kücükakin, Thue Bisgaard, Viggo Kristiansen, Niels Christian Hjortsø, Debra J. Skene, Jacob Rosenberg

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    Abstrakt

    BACKGROUND:: In this study, we investigated whether melatonin administration could improve postoperative subjective sleep quality and reduce discomfort. METHODS:: One hundred twenty-one patients scheduled for elective ambulatory laparoscopic cholecystectomy were randomized to oral 5 mg melatonin (n = 60) or placebo (n = 61) for 3 nights after surgery. Subjective sleep quality, sleep duration, sleep timing, and subjective discomfort (fatigue, general well-being, and pain) were measured. RESULTS:: Sleep latency was significantly reduced in the melatonin group (mean [sd] 14 min [18]) compared with placebo (28 min [41]) on the first postoperative night (P = 0.015). The rest of the measured outcome variables did not differ between groups. CONCLUSIONS:: Melatonin did not improve subjective sleep quality or discomfort compared with placebo after laparoscopic cholecystectomy.

    OriginalsprogEngelsk
    Sider (fra-til)1152-1156
    Antal sider5
    TidsskriftAnesthesia and Analgesia
    Vol/bind108
    Udgave nummer4
    DOI
    StatusUdgivet - apr. 2009

    Fingeraftryk Udforsk hvilke forskningsemner 'The effect of melatonin on sleep quality after laparoscopic cholecystectomy: A randomized, placebo-controlled trial' indeholder.

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