The clinical utility of FDG PET/CT among solid organ transplant recipients suspected of malignancy or infection

Neval E. Wareham, J. D. Lundgren, C. Da Cunha-Bang, F. Gustafsson, M. Iversen, H. H. Johannesen, A. Kjær, A. Rasmussen, H. Sengeløv, S. S. Sørensen, B. M. Fischer

Publikation: Bidrag til tidsskriftArtikelForskningpeer review

Abstrakt

Purpose: Solid organ transplant (SOT) recipients are at high risk of developing infections and malignancies. 18F-FDG PET/CT may enable timely detection of these diseases and help to ensure early intervention. We aimed to describe the clinical utility of FDG PET/CT in consecutive, diagnostic unresolved SOT recipients transplanted from January 2004 to May 2015. Methods: Recipients with a post-transplant FDG PET/CT performed as part of diagnostic work-up were included. Detailed chart reviews were done to extract relevant clinical information and determine the final diagnosis related to the FDG PET/CT. Based on á priori defined criteria and the final diagnosis, results from each scan were classified as true or false, and diagnostic values determined. Results: Among the 1,814 recipients in the cohort, 145 had an FDG PET/CT performed; 122 under the indication of diagnostically unresolved symptoms with a suspicion of malignancy or infection. The remaining (N = 23) had an FDG PET/CT to follow-up on a known disease or to stage a known malignancy. The 122 recipients underwent a total of 133 FDG PET/CT scans performed for a suspected malignancy (66 %) or an infection (34 %). Sensitivity, specificity, and positive and negative predictive values of the FDG PET/CT in diagnosing these conditions were 97, 84, 87, and 96 %, respectively. Conclusion: FDG PET/CT is an accurate diagnostic tool for the work-up of diagnostic unresolved SOT recipients suspected of malignancy or infection. The high sensitivity and NPV underlines the potential usefulness of PET/CT for excluding malignancy or focal infections in this often complex clinical situation.

OriginalsprogEngelsk
Sider (fra-til)421-431
Antal sider11
TidsskriftEuropean Journal of Nuclear Medicine and Molecular Imaging
Vol/bind44
Udgave nummer3
DOI
StatusUdgivet - 1 mar. 2017

Fingeraftryk Udforsk hvilke forskningsemner 'The clinical utility of FDG PET/CT among solid organ transplant recipients suspected of malignancy or infection' indeholder.

Citationsformater