Purpose: To determine the association between cuticular drusen (CD) and kidney function. Design: observational case-control study. Methods: Setting: Population-based. Patients or Study Population: 53 participants with (CD) and 53 age- and sex-matched controls, selected from the Danish Rural Eye Study. Cuticular drusen participants were diagnosed using fluorescein angiography and controls were excluded if the patients were suspected of having CD on fundus photography or did not have an available estimated glomerular filtration rate. Main Outcome Measures: creatinine and estimated glomerular filtration rate. Results: The mean estimated glomerular filtration rate of those with CD was 73.3 mL·min·1.73 m -2 (95% confidence interval [CI]: 70.0-76.6) and 73.4 mL·minute -1 ·1.73 m -2 (95% CI: 69.5-77.3) in controls. The difference was not significant (P: 0.970). The mean creatinine among those with CD was 72.8 mol/L (69.3-76.4) and 73.5 mol/L (95% CI: 69.3-77.6) among controls. The difference was not significant (P 0.820). Conclusion: The authors did not find an association between a (CD) diagnosis and decreased kidney function at a population level.