The apolipoprotein E ε4-allele and antihypertensive treatment are associated with increased risk of cerebral MRI white matter hyperintensities

P. Høgh, E. Garde, E. L. Mortensen, O. S. Jørgensen, K. Krabbe, G. Waldemar

    Publikation: Bidrag til tidsskriftArtikelForskningpeer review

    Abstrakt

    Objective - Apolipoprotein E-ε4 (APOE-ε4) is a potential risk factor for cerebral vascular disease. The aim of the present study was to examine the relative importance of APOE-ε4 and other relevant risk factors for the extent of cerebral white matter hyperintensity (WMH) in a community-based sample of elderly subjects. Materials and methods - From a cohort of 976 subjects born in 1914, APOE genotype was determined and MRI examinations were carried out in 75 subjects. WMH were rated using a standard semi-quantitative method. ANOVA and regression analyses were conducted to explore the relative importance of the potential risk factors. Results - APOE genotype and antihypertensive treatment were significantly associated with severity of total WMH load (P < 0.05). Conclusions - The study confirmed the association between APOE-ε4 and WMH. Pharmaceutical treatment for arterial hypertension was also associated with the total burden of WMH in this study.

    OriginalsprogEngelsk
    Sider (fra-til)248-253
    Antal sider6
    TidsskriftActa Neurologica Scandinavica
    Vol/bind115
    Udgave nummer4
    DOI
    StatusUdgivet - 1 apr. 2007

    Fingeraftryk Udforsk hvilke forskningsemner 'The apolipoprotein E ε4-allele and antihypertensive treatment are associated with increased risk of cerebral MRI white matter hyperintensities' indeholder.

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