TY - JOUR
T1 - The ADDITION study
T2 - proposed trial of the cost-effectiveness of an intensive multifactorial intervention on morbidity and mortality among people with Type 2 diabetes detected by screening
AU - Lauritzen, T.
AU - Griffin, S.
AU - Borch-Johnsen, K.
AU - Wareham, N. J.
AU - Wolffenbuttel, B. H.R.
AU - Rutten, G.
PY - 2000/9
Y1 - 2000/9
N2 - OBJECTIVE: The overall aims of the ADDITION study are to evaluate whether screening for prevalent undiagnosed Type 2 diabetes is feasible, and whether subsequent optimised intensive treatment of diabetes, and associated risk factors, is feasible and beneficial.DESIGN: Population-based screening in three European countries followed by an open, randomised controlled trial.SUBJECTS AND METHODS: People aged 40–69 y in the community, without known diabetes, will be offered a random capillary blood glucose screening test by their primary care physicians, followed, if equal to or greater than 5.5 mmol/l, by fasting and 2-h post-glucose-challenge blood glucose measurements. Three thousand newly diagnosed patients will subsequently receive conventional treatment (according to current national guidelines) or intensive multifactorial treatment (lifestyle advice, prescription of aspirin and ACE-inhibitors, in addition to protocol-driven tight control of blood glucose, blood pressure and cholesterol). Patients allocated to intensive treatment will be further randomised to centre-specific interventions to motivate adherence to lifestyle changes and medication. Duration of follow-up is planned for 5 y. Endpoints will include mortality, macrovascular and microvascular complications, patient health status and satisfaction, process-of-care indicators and costs.
AB - OBJECTIVE: The overall aims of the ADDITION study are to evaluate whether screening for prevalent undiagnosed Type 2 diabetes is feasible, and whether subsequent optimised intensive treatment of diabetes, and associated risk factors, is feasible and beneficial.DESIGN: Population-based screening in three European countries followed by an open, randomised controlled trial.SUBJECTS AND METHODS: People aged 40–69 y in the community, without known diabetes, will be offered a random capillary blood glucose screening test by their primary care physicians, followed, if equal to or greater than 5.5 mmol/l, by fasting and 2-h post-glucose-challenge blood glucose measurements. Three thousand newly diagnosed patients will subsequently receive conventional treatment (according to current national guidelines) or intensive multifactorial treatment (lifestyle advice, prescription of aspirin and ACE-inhibitors, in addition to protocol-driven tight control of blood glucose, blood pressure and cholesterol). Patients allocated to intensive treatment will be further randomised to centre-specific interventions to motivate adherence to lifestyle changes and medication. Duration of follow-up is planned for 5 y. Endpoints will include mortality, macrovascular and microvascular complications, patient health status and satisfaction, process-of-care indicators and costs.
KW - Family practice
KW - Intensive
KW - Multifactorial intervention
KW - Randomised controlled trial
KW - Screening
KW - Type 2 diabetes
UR - http://www.scopus.com/inward/record.url?scp=0033808127&partnerID=8YFLogxK
U2 - 10.1038/sj.ijo.0801420
DO - 10.1038/sj.ijo.0801420
M3 - Article
C2 - 11063279
AN - SCOPUS:0033808127
SN - 0307-0565
VL - 24
SP - S6-S11
JO - International Journal of Obesity
JF - International Journal of Obesity
ER -