T47D breast cancer cells switch from ER/HER to HER/c-Src signaling upon acquiring resistance to the antiestrogen fulvestrant

Tove Kirkegaard, Susanne K Hansen, Sarah L Larsen, Birgit E Reiter, Boe S Sørensen, Anne E Lykkesfeldt

    Publikation: Bidrag til tidsskriftArtikelForskningpeer review

    Abstrakt

    In this study, T47D cell lines resistant to the antiestrogen fulvestrant were established and analyzed to explore, whether a switch to HER signaling, as seen in fulvestrant resistant MCF-7 cell lines, is a general resistance mechanism. We find that parental T47D cells depend on ER and HER signaling for growth. Fulvestrant resistant T47D cells have lost ER expression and, although HER2 was over expressed, growth was only partially driven by HER receptors. Instead c-Src was important for resistant growth. Thus, the T47D and MCF-7 model system unravel different resistance mechanisms which may be important for fulvestrant resistant breast cancer patients.

    OriginalsprogEngelsk
    Sider (fra-til)90-100
    Antal sider11
    TidsskriftCancer Letters
    Vol/bind344
    Udgave nummer1
    DOI
    StatusUdgivet - 1 mar. 2014

    Fingeraftryk

    Udforsk hvilke forskningsemner 'T47D breast cancer cells switch from ER/HER to HER/c-Src signaling upon acquiring resistance to the antiestrogen fulvestrant' indeholder.

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