Systemic T-cell activation in acute clinically isolated optic neuritis

Hanne Roed, Jette Frederiksen, Annika Langkilde, Torben Lykke Sørensen, Martin Lauritzen, Finn Sellebjerg

    Publikation: Bidrag til tidsskriftArtikelForskningpeer review

    Abstrakt

    We examined untreated 60 patients with acute monosymptomatic optic neuritis (ON). Patients examined early after onset showed increased expression of HLA-DR and CD45R0 on CD4 and CD8 T cells. Expression of HLA-DR on CD4 T cells was higher in patients without IgG oligoclonal bands. Expression of HLA-DR on CD4 and CD8 T cells correlated negatively with measures of disease activity and positively with measures of good visual function, and expression of CD45R0 on CD4 T cells correlated negatively with measures of disease activity. We hypothesize that HLA-DR expression may characterize a protective T-cell subset in ON.

    OriginalsprogEngelsk
    Sider (fra-til)165-172
    Antal sider8
    TidsskriftJournal of Neuroimmunology
    Vol/bind162
    Udgave nummer1-2
    DOI
    StatusUdgivet - maj 2005

    Fingeraftryk Udforsk hvilke forskningsemner 'Systemic T-cell activation in acute clinically isolated optic neuritis' indeholder.

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