Systemic T-cell activation in acute clinically isolated optic neuritis

Hanne Roed; Jette Frederiksen; Annika Langkilde; Torben Lykke Sørensen; Martin Lauritzen; Finn Sellebjerg

doi:10.1016/j.jneuroim.2005.02.002

Systemic T-cell activation in acute clinically isolated optic neuritis

Hanne Roed^*, Jette Frederiksen, Annika Langkilde, Torben Lykke Sørensen, Martin Lauritzen, Finn Sellebjerg

^*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift › Artikel › Forskning › peer review

Abstract

We examined untreated 60 patients with acute monosymptomatic optic neuritis (ON). Patients examined early after onset showed increased expression of HLA-DR and CD45R0 on CD4 and CD8 T cells. Expression of HLA-DR on CD4 T cells was higher in patients without IgG oligoclonal bands. Expression of HLA-DR on CD4 and CD8 T cells correlated negatively with measures of disease activity and positively with measures of good visual function, and expression of CD45R0 on CD4 T cells correlated negatively with measures of disease activity. We hypothesize that HLA-DR expression may characterize a protective T-cell subset in ON.

Originalsprog	Engelsk
Sider (fra-til)	165-172
Antal sider	8
Tidsskrift	Journal of Neuroimmunology
Vol/bind	162
Udgave nummer	1-2
DOI	https://doi.org/10.1016/j.jneuroim.2005.02.002
Status	Udgivet - maj 2005

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Citationsformater

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title = "Systemic T-cell activation in acute clinically isolated optic neuritis",

abstract = "We examined untreated 60 patients with acute monosymptomatic optic neuritis (ON). Patients examined early after onset showed increased expression of HLA-DR and CD45R0 on CD4 and CD8 T cells. Expression of HLA-DR on CD4 T cells was higher in patients without IgG oligoclonal bands. Expression of HLA-DR on CD4 and CD8 T cells correlated negatively with measures of disease activity and positively with measures of good visual function, and expression of CD45R0 on CD4 T cells correlated negatively with measures of disease activity. We hypothesize that HLA-DR expression may characterize a protective T-cell subset in ON.",

keywords = "CD45R0, Flow cytometry, HLA-DR, MRI, Optic neuritis, T-cell immunology",

author = "Hanne Roed and Jette Frederiksen and Annika Langkilde and S{\o}rensen, {Torben Lykke} and Martin Lauritzen and Finn Sellebjerg",

year = "2005",

month = may,

doi = "10.1016/j.jneuroim.2005.02.002",

language = "English",

volume = "162",

pages = "165--172",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

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TY - JOUR

T1 - Systemic T-cell activation in acute clinically isolated optic neuritis

AU - Roed, Hanne

AU - Frederiksen, Jette

AU - Langkilde, Annika

AU - Sørensen, Torben Lykke

AU - Lauritzen, Martin

AU - Sellebjerg, Finn

PY - 2005/5

Y1 - 2005/5

N2 - We examined untreated 60 patients with acute monosymptomatic optic neuritis (ON). Patients examined early after onset showed increased expression of HLA-DR and CD45R0 on CD4 and CD8 T cells. Expression of HLA-DR on CD4 T cells was higher in patients without IgG oligoclonal bands. Expression of HLA-DR on CD4 and CD8 T cells correlated negatively with measures of disease activity and positively with measures of good visual function, and expression of CD45R0 on CD4 T cells correlated negatively with measures of disease activity. We hypothesize that HLA-DR expression may characterize a protective T-cell subset in ON.

AB - We examined untreated 60 patients with acute monosymptomatic optic neuritis (ON). Patients examined early after onset showed increased expression of HLA-DR and CD45R0 on CD4 and CD8 T cells. Expression of HLA-DR on CD4 T cells was higher in patients without IgG oligoclonal bands. Expression of HLA-DR on CD4 and CD8 T cells correlated negatively with measures of disease activity and positively with measures of good visual function, and expression of CD45R0 on CD4 T cells correlated negatively with measures of disease activity. We hypothesize that HLA-DR expression may characterize a protective T-cell subset in ON.

KW - CD45R0

KW - Flow cytometry

KW - HLA-DR

KW - MRI

KW - Optic neuritis

KW - T-cell immunology

UR - http://www.scopus.com/inward/record.url?scp=17044378585&partnerID=8YFLogxK

U2 - 10.1016/j.jneuroim.2005.02.002

DO - 10.1016/j.jneuroim.2005.02.002

M3 - Article

C2 - 15833372

AN - SCOPUS:17044378585

SN - 0165-5728

VL - 162

SP - 165

EP - 172

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 1-2

ER -

Systemic T-cell activation in acute clinically isolated optic neuritis

Abstract

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