Surface immunoglobulin on B lymphocytes as a potential target for specific peptide ligands in chronic lymphocytic leukaemia

P. B. Szecsi, C. Schafer-Nielsen, G. G. Gisselø

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    Abstrakt

    With the aim of producing unique targets for malignant cells we have identified peptide ligands for the clonal surface immunoglobulin isolated from the B cells of a chronic lymphocytic leukaemia (CLL) patient. The peptides were identified from random-peptide phage-display libraries. The obtained ligands bound specifically to the surface of the target lymphocytes as well as to clonal immunoglobulin in lysate from the same cells. Peptide-based antigen mimotopes may have a future use in targeted therapy of CLL and other B-cell-derived malignancies displaying surface immunoglobulin.

    OriginalsprogEngelsk
    Sider (fra-til)549-554
    Antal sider6
    TidsskriftBritish Journal of Haematology
    Vol/bind116
    Udgave nummer3
    DOI
    StatusUdgivet - 1 jan. 2002

    Fingeraftryk

    Udforsk hvilke forskningsemner 'Surface immunoglobulin on B lymphocytes as a potential target for specific peptide ligands in chronic lymphocytic leukaemia' indeholder.

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